The bHLH transcription factor HBI1 mediates the trade-off between growth and pathogen-associated molecular pattern-triggered immunity in Arabidopsis

Min Fan, Ming Yi Bai, Jung Gun Kim, Tina Wang, Eunkyoo Oh, Lawrence Chen, Chan Ho Park, Seung Hyun Son, Seong Ki Kim, Mary Beth Mudgett, Zhi Yong Wang

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The trade-off between growth and immunity is crucial for survival in plants. However, the mechanism underlying growth-immunity balance has remained elusive. The PRE-IBH1-HBI1 tripartite helix-loop-helix/basic helix-loop-helix module is part of a central transcription network that mediates growth regulation by several hormonal and environmental signals. Here, genome-wide analyses of HBI1 target genes show that HBI1 regulates both overlapping and unique targets compared with other DNA binding components of the network in Arabidopsis thaliana, supporting a role in specifying network outputs and fine-tuning feedback regulation. Furthermore, HBI1 negatively regulates a subset of genes involved in immunity, and pathogen-associated molecular pattern (PAMP) signals repress HBI1 transcription. Constitutive overexpression and loss-of-function experiments show that HBI1 inhibits PAMP-induced growth arrest, defense gene expression, reactive oxygen species production, and resistance to pathogen. These results show that HBI1, as a component of the central growth regulation circuit, functions as a major node of crosstalk that mediates a trade-off between growth and immunity in plants.

Original languageEnglish
Pages (from-to)828-841
Number of pages14
JournalPlant Cell
Volume26
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Basic Helix-Loop-Helix Transcription Factors
Arabidopsis
Immunity
transcription factors
immunity
pathogens
Growth
transcription (genetics)
Plant Immunity
reactive oxygen species
genes
Arabidopsis thaliana
gene expression
Genes
genome
Pathogen-Associated Molecular Pattern Molecules
Reactive Oxygen Species
DNA
Genome
Gene Expression

ASJC Scopus subject areas

  • Plant Science
  • Cell Biology

Cite this

The bHLH transcription factor HBI1 mediates the trade-off between growth and pathogen-associated molecular pattern-triggered immunity in Arabidopsis. / Fan, Min; Bai, Ming Yi; Kim, Jung Gun; Wang, Tina; Oh, Eunkyoo; Chen, Lawrence; Park, Chan Ho; Son, Seung Hyun; Kim, Seong Ki; Mudgett, Mary Beth; Wang, Zhi Yong.

In: Plant Cell, Vol. 26, No. 2, 01.01.2014, p. 828-841.

Research output: Contribution to journalArticle

Fan, M, Bai, MY, Kim, JG, Wang, T, Oh, E, Chen, L, Park, CH, Son, SH, Kim, SK, Mudgett, MB & Wang, ZY 2014, 'The bHLH transcription factor HBI1 mediates the trade-off between growth and pathogen-associated molecular pattern-triggered immunity in Arabidopsis', Plant Cell, vol. 26, no. 2, pp. 828-841. https://doi.org/10.1105/tpc.113.121111
Fan, Min ; Bai, Ming Yi ; Kim, Jung Gun ; Wang, Tina ; Oh, Eunkyoo ; Chen, Lawrence ; Park, Chan Ho ; Son, Seung Hyun ; Kim, Seong Ki ; Mudgett, Mary Beth ; Wang, Zhi Yong. / The bHLH transcription factor HBI1 mediates the trade-off between growth and pathogen-associated molecular pattern-triggered immunity in Arabidopsis. In: Plant Cell. 2014 ; Vol. 26, No. 2. pp. 828-841.
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