The binding of fluorophores to proteins depends on the cellular environment

Yun Kyung Kim, Jun Seok Lee, Xuezhi Bi, Hyung Ho Ha, Shin Hui Ng, Young Hoon Ahn, Jae Jung Lee, Bridget K. Wagner, Paul A. Clemons, Young Tae Chang

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Lighten up! To investigate intracellular binders of myotube-specific probes, a thiol-reactive derivative, CDy2, was prepared. In live cells, the derivative selectively localizes in mitochondria and covalently labels its binding partners.

Original languageEnglish
Pages (from-to)2761-2763
Number of pages3
JournalAngewandte Chemie - International Edition
Volume50
Issue number12
DOIs
Publication statusPublished - 2011 Mar 14
Externally publishedYes

Keywords

  • fluorescent probes
  • imaging agents
  • live-cell imaging
  • mitochondria
  • rosamine

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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