Abstract
This study examines changes in the urinary 1-hydroxypyrene (1-OHP) concentration as a polycyclic aromatic hydrocarbon (PAH) metabolite related to smoking among eight volunteers. The study subjects consisted of 8 participants (2 smokers, 4 ex-smokers and 2 non-smokers; mean age 23, range 21 ∼ 24 years old) in a smoking cessation program. Three urine samples were collected each week for 4 weeks from each participant to give a total of 96 urine samples. None of the participants smoked during the study period. Levels of urinary 1-OHP, as an internal dose marker of smoke containing PAHs, were measured by high performance liquid chromatography (HPLC) fluorescence detector. Urinary 1-OHP levels in the ex-smokers were decreased during the 4 weeks study period, due to ambient sources of PAH exposure. Thus, smoking cessation was only expected to result in reduction of urinary 1-OHP. Urinary 1-OHP levels were significantly correlated with the amounts of cigarettes smoked, as assessed by the questionnaire (Spearman's correlation coefficient, r=0.23, P=0.03). This study suggested that urinary 1-OHP can be a potentially useful biomarker of smoke.
| Original language | English |
|---|---|
| Pages (from-to) | 439-442 |
| Number of pages | 4 |
| Journal | International Journal of Environmental Research |
| Volume | 4 |
| Issue number | 3 |
| Publication status | Published - 2010 Aug 17 |
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Keywords
- 1-hydroxypyrene
- Biomarker
- Cigarette smoking
- Polycyclic aromatic hydrocarbons
ASJC Scopus subject areas
- Environmental Science(all)
Cite this
The biological monitoring of urinary 1-hydroxypyrene by PAH exposure among smokers. / Lee, K. H.; Byeon, Sang Hoon.
In: International Journal of Environmental Research, Vol. 4, No. 3, 17.08.2010, p. 439-442.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The biological monitoring of urinary 1-hydroxypyrene by PAH exposure among smokers
AU - Lee, K. H.
AU - Byeon, Sang Hoon
PY - 2010/8/17
Y1 - 2010/8/17
N2 - This study examines changes in the urinary 1-hydroxypyrene (1-OHP) concentration as a polycyclic aromatic hydrocarbon (PAH) metabolite related to smoking among eight volunteers. The study subjects consisted of 8 participants (2 smokers, 4 ex-smokers and 2 non-smokers; mean age 23, range 21 ∼ 24 years old) in a smoking cessation program. Three urine samples were collected each week for 4 weeks from each participant to give a total of 96 urine samples. None of the participants smoked during the study period. Levels of urinary 1-OHP, as an internal dose marker of smoke containing PAHs, were measured by high performance liquid chromatography (HPLC) fluorescence detector. Urinary 1-OHP levels in the ex-smokers were decreased during the 4 weeks study period, due to ambient sources of PAH exposure. Thus, smoking cessation was only expected to result in reduction of urinary 1-OHP. Urinary 1-OHP levels were significantly correlated with the amounts of cigarettes smoked, as assessed by the questionnaire (Spearman's correlation coefficient, r=0.23, P=0.03). This study suggested that urinary 1-OHP can be a potentially useful biomarker of smoke.
AB - This study examines changes in the urinary 1-hydroxypyrene (1-OHP) concentration as a polycyclic aromatic hydrocarbon (PAH) metabolite related to smoking among eight volunteers. The study subjects consisted of 8 participants (2 smokers, 4 ex-smokers and 2 non-smokers; mean age 23, range 21 ∼ 24 years old) in a smoking cessation program. Three urine samples were collected each week for 4 weeks from each participant to give a total of 96 urine samples. None of the participants smoked during the study period. Levels of urinary 1-OHP, as an internal dose marker of smoke containing PAHs, were measured by high performance liquid chromatography (HPLC) fluorescence detector. Urinary 1-OHP levels in the ex-smokers were decreased during the 4 weeks study period, due to ambient sources of PAH exposure. Thus, smoking cessation was only expected to result in reduction of urinary 1-OHP. Urinary 1-OHP levels were significantly correlated with the amounts of cigarettes smoked, as assessed by the questionnaire (Spearman's correlation coefficient, r=0.23, P=0.03). This study suggested that urinary 1-OHP can be a potentially useful biomarker of smoke.
KW - 1-hydroxypyrene
KW - Biomarker
KW - Cigarette smoking
KW - Polycyclic aromatic hydrocarbons
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UR - http://www.scopus.com/inward/citedby.url?scp=77955495913&partnerID=8YFLogxK
M3 - Article
VL - 4
SP - 439
EP - 442
JO - International Journal of Environmental Research
JF - International Journal of Environmental Research
SN - 1735-6865
IS - 3
ER -