The biology of prostaglandins and their role as a target for allergic airway disease therapy

Kijeong Lee; Sang Hag Lee; Tae Hoon Kim

doi:10.3390/ijms21051851

The biology of prostaglandins and their role as a target for allergic airway disease therapy

Kijeong Lee, Sang Hag Lee, Tae Hoon Kim

Department of Otorhinolaryngology-Head and Neck Surgery

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and thromboxane B2. PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through different mechanisms according to the receptors with which they are associated. In this review article, we have focused on the metabolism of the cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell types involved in allergic airway diseases, including asthma, allergic rhinitis, nasal polyposis, and aspirin-exacerbated respiratory disease.

Original language	English
Article number	1851
Journal	International journal of molecular sciences
Volume	21
Issue number	5
DOIs	https://doi.org/10.3390/ijms21051851
Publication status	Published - 2020 Mar 1

Keywords

AERD
Allergic rhinitis
Allergy
Asthma
PGD
PGE
Prostaglandins

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "The biology of prostaglandins and their role as a target for allergic airway disease therapy",

abstract = "Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and thromboxane B2. PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through different mechanisms according to the receptors with which they are associated. In this review article, we have focused on the metabolism of the cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell types involved in allergic airway diseases, including asthma, allergic rhinitis, nasal polyposis, and aspirin-exacerbated respiratory disease.",

keywords = "AERD, Allergic rhinitis, Allergy, Asthma, PGD, PGE, Prostaglandins",

author = "Kijeong Lee and Lee, {Sang Hag} and Kim, {Tae Hoon}",

note = "Funding Information: Funding: This research was supported by the Basic Science Research Program, National Research Foundation of Korea, funded by the Ministry of Science and Technology and the Ministry of Science, ICT & Future Planning (2017R1A2B2003575), and the Korea Health Technology R&D Project (HI17C0387), Korea Health Industry Development Institute (KHIDI), and the Ministry of Health & Welfare. This research was also supported by a Korea University grant, and a grant from Korea University Medical Center as well as by Anam Hospital, Seoul, Republic of Korea (O1905011).",

year = "2020",

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journal = "International Journal of Molecular Sciences",

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AU - Lee, Kijeong

AU - Lee, Sang Hag

AU - Kim, Tae Hoon

N1 - Funding Information: Funding: This research was supported by the Basic Science Research Program, National Research Foundation of Korea, funded by the Ministry of Science and Technology and the Ministry of Science, ICT & Future Planning (2017R1A2B2003575), and the Korea Health Technology R&D Project (HI17C0387), Korea Health Industry Development Institute (KHIDI), and the Ministry of Health & Welfare. This research was also supported by a Korea University grant, and a grant from Korea University Medical Center as well as by Anam Hospital, Seoul, Republic of Korea (O1905011).

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and thromboxane B2. PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through different mechanisms according to the receptors with which they are associated. In this review article, we have focused on the metabolism of the cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell types involved in allergic airway diseases, including asthma, allergic rhinitis, nasal polyposis, and aspirin-exacerbated respiratory disease.

AB - Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and thromboxane B2. PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through different mechanisms according to the receptors with which they are associated. In this review article, we have focused on the metabolism of the cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell types involved in allergic airway diseases, including asthma, allergic rhinitis, nasal polyposis, and aspirin-exacerbated respiratory disease.

KW - AERD

KW - Allergic rhinitis

KW - Allergy

KW - Asthma

KW - PGD

KW - PGE

KW - Prostaglandins

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