The biomechanical evaluation of calcium phosphate cements for use in vertebroplasty

Suk Joo Hong, Youn Kwan Park, Hyuk Kim Jung, Hyuck Lee Soon, Nam Ryu Kyung, Min Park Cheol, Soo Kim Yeon

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Object. The authors evaluate the biomechanical properties of vertebral bodies (VBs) stabilized with calcium phosphate (CaP) cements for use in vertebroplasty in comparison with polymethylmethacrylate (PMMA). Methods. In the first phase of the study, 73 VBs (T3-L2; thoracic region [T3-8] and thoracolumbar region [T9-L2]) were collected from seven fresh human cadavers. Compression tests were performed before and after vertebroplasty using PMMA (compression strength 80 MPa) and three kinds of CaP cements - CaP1 (5 MPa), CaP2 (20 MPa), and CaP3 (50 MPa). The authors compared the maximal compression loads (MCLs) and stiffness before and after vertebroplasty in each of the four cement groups. In the second phase of the study, 18 paired spinal units (PSUs) were collected from three fresh human cadavers, and the authors injected two types of cement selected from the first phase of the study into the lower level of six PSUs. They compared the MCLs of the untreated and two treated groups (there were six PSUs in each type of group) to analyze the tendency of inducing compression fractures in the upper level of the PSUs. The MCLs of the PMMA-injected vertebrae were significantly increased after vertebroplasty. The MCL levels of the CaP3-injected vertebrae and the CaP2-injected thoracolumbar vertebrae were decreased from those of untreated vertebrae without being significant. The MCLs of CaP1-injected vertebrae and CaP2-injected thoracic vertebrae were significantly decreased after vertebroplasty. The stiffness of all cement groups was decreased after vertebroplasty compared with initial stiffness, significantly so in all three thoracic CaP groups. In the second compression test with PSUs, the MCLs of the CaP2- and CaP3-injected PSUs were not significantly different from those of the untreated control PSUs. Conclusions. The CaP3-injected vertebrae restored the MCLs of human vertebrae closer to their initial levels than the PMMA-injected vertebrae did. The CaP2- and CaP3-injected PSUs showed no tendency to induce compression fractures in adjacent VBs.

Original languageEnglish
Pages (from-to)154-159
Number of pages6
JournalJournal of Neurosurgery: Spine
Volume4
Issue number2
DOIs
Publication statusPublished - 2006 Feb 1

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Vertebroplasty
Spine
Polymethyl Methacrylate
Compression Fractures
Cadaver
Thorax
Thoracic Vertebrae
calcium phosphate

Keywords

  • Compression fracture
  • Experimental study
  • Interventional procedure
  • Spine

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology

Cite this

The biomechanical evaluation of calcium phosphate cements for use in vertebroplasty. / Hong, Suk Joo; Park, Youn Kwan; Jung, Hyuk Kim; Soon, Hyuck Lee; Kyung, Nam Ryu; Cheol, Min Park; Yeon, Soo Kim.

In: Journal of Neurosurgery: Spine, Vol. 4, No. 2, 01.02.2006, p. 154-159.

Research output: Contribution to journalArticle

Hong, Suk Joo ; Park, Youn Kwan ; Jung, Hyuk Kim ; Soon, Hyuck Lee ; Kyung, Nam Ryu ; Cheol, Min Park ; Yeon, Soo Kim. / The biomechanical evaluation of calcium phosphate cements for use in vertebroplasty. In: Journal of Neurosurgery: Spine. 2006 ; Vol. 4, No. 2. pp. 154-159.
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AU - Cheol, Min Park

AU - Yeon, Soo Kim

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N2 - Object. The authors evaluate the biomechanical properties of vertebral bodies (VBs) stabilized with calcium phosphate (CaP) cements for use in vertebroplasty in comparison with polymethylmethacrylate (PMMA). Methods. In the first phase of the study, 73 VBs (T3-L2; thoracic region [T3-8] and thoracolumbar region [T9-L2]) were collected from seven fresh human cadavers. Compression tests were performed before and after vertebroplasty using PMMA (compression strength 80 MPa) and three kinds of CaP cements - CaP1 (5 MPa), CaP2 (20 MPa), and CaP3 (50 MPa). The authors compared the maximal compression loads (MCLs) and stiffness before and after vertebroplasty in each of the four cement groups. In the second phase of the study, 18 paired spinal units (PSUs) were collected from three fresh human cadavers, and the authors injected two types of cement selected from the first phase of the study into the lower level of six PSUs. They compared the MCLs of the untreated and two treated groups (there were six PSUs in each type of group) to analyze the tendency of inducing compression fractures in the upper level of the PSUs. The MCLs of the PMMA-injected vertebrae were significantly increased after vertebroplasty. The MCL levels of the CaP3-injected vertebrae and the CaP2-injected thoracolumbar vertebrae were decreased from those of untreated vertebrae without being significant. The MCLs of CaP1-injected vertebrae and CaP2-injected thoracic vertebrae were significantly decreased after vertebroplasty. The stiffness of all cement groups was decreased after vertebroplasty compared with initial stiffness, significantly so in all three thoracic CaP groups. In the second compression test with PSUs, the MCLs of the CaP2- and CaP3-injected PSUs were not significantly different from those of the untreated control PSUs. Conclusions. The CaP3-injected vertebrae restored the MCLs of human vertebrae closer to their initial levels than the PMMA-injected vertebrae did. The CaP2- and CaP3-injected PSUs showed no tendency to induce compression fractures in adjacent VBs.

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