TY - JOUR
T1 - The bond survival time variation of polymorphic amyloid fibrils in the mechanical insight
AU - Lee, Myeongsang
AU - Baek, Inchul
AU - Chang, Hyun Joon
AU - Yoon, Gwonchan
AU - Na, Sungsoo
N1 - Funding Information:
S.N. gratefully acknowledges the financial support from NRF under Grant Nos. 2011-0007272 , 2011-0029477 , and 2012-0000785 . G.Y. is grateful to the financial support from NRF under Grant No. 2012R1A1A2038373 and Korea University Grant.
PY - 2014/4/29
Y1 - 2014/4/29
N2 - The structure-property relationships of biological materials such as amyloid fibrils are important to developing therapeutic strategies for amyloid-related diseases. The mechanical characterization of biological materials can provide insight into such relationships. In this study, polymorphic human islet polypeptide (hIAPP) fibrils were constructed with molecular modeling, and a constant-force bending simulation was performed to characterize the different mechanical behaviors of polymorphic hIAPP protofibrils. Our simulation results showed that, owing to their different intramolecular interactions, the fracture times of polymorphic hIAPP protofibrils depend on polymorphic structures.
AB - The structure-property relationships of biological materials such as amyloid fibrils are important to developing therapeutic strategies for amyloid-related diseases. The mechanical characterization of biological materials can provide insight into such relationships. In this study, polymorphic human islet polypeptide (hIAPP) fibrils were constructed with molecular modeling, and a constant-force bending simulation was performed to characterize the different mechanical behaviors of polymorphic hIAPP protofibrils. Our simulation results showed that, owing to their different intramolecular interactions, the fracture times of polymorphic hIAPP protofibrils depend on polymorphic structures.
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U2 - 10.1016/j.cplett.2014.03.043
DO - 10.1016/j.cplett.2014.03.043
M3 - Article
AN - SCOPUS:84898603428
SN - 0009-2614
VL - 600
SP - 68
EP - 72
JO - Chemical Physics Letters
JF - Chemical Physics Letters
ER -
