The bond survival time variation of polymorphic amyloid fibrils in the mechanical insight

Myeongsang Lee, Inchul Baek, Hyun Joon Chang, Gwonchan Yoon, Sung Soo Na

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The structure-property relationships of biological materials such as amyloid fibrils are important to developing therapeutic strategies for amyloid-related diseases. The mechanical characterization of biological materials can provide insight into such relationships. In this study, polymorphic human islet polypeptide (hIAPP) fibrils were constructed with molecular modeling, and a constant-force bending simulation was performed to characterize the different mechanical behaviors of polymorphic hIAPP protofibrils. Our simulation results showed that, owing to their different intramolecular interactions, the fracture times of polymorphic hIAPP protofibrils depend on polymorphic structures.

Original languageEnglish
Pages (from-to)68-72
Number of pages5
JournalChemical Physics Letters
Volume600
DOIs
Publication statusPublished - 2014 Apr 29

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Physics and Astronomy(all)

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