The bronchial biopsies and steroid response in unexplained chronic non- productive cough

Yeub Lee Sang Yeub Lee, Cheol Jeong Hye Cheol Jeong, Kyu Kim Kyung Kyu Kim, Je Hyeong Kim, Hwan Kwan Young Hwan Kwan, Sung Yong Lee, Ra Lee So Ra Lee, Deuk Cho Hyun Deuk Cho, Hyung Lee Sin Hyung Lee, Jeong Shim Jae Jeong Shim, Yun Cho Jae Yun Cho, Gyum Kim Han Gyum Kim, Ho Kang Kyung Ho Kang, Hwa Yoo Se Hwa Yoo, Ho In Kwang Ho In

Research output: Contribution to journalArticle

Abstract

Background: The purpose of this study was to examine the causes and pathologic process of chronic non-productive cough as an isolated symptom with a normal spirometry and chest radiograph by investigating clinicopathologic findings. Method: We studied 25 adults with chronic non- productive cough over a 3-week period with a normal chest radiograph and pulmonary function tests without any other symptoms. Clinical assessment, cough score, chest and sinus radiograph, pulmonary function tests, methacholine challenge, allergic skin prick test, and bronchoscopy for bronchial biopsies were performed. Subjects were then treated with prednisolone 20 to 30 mg/day for 1 to 2 weeks. Results: The experimental group was divided into two subgroups-those infiltrated with eosinophils, and those infiltrated with lymphocytes depending on eosinophil and lymphocyte counts, both of which were respectively higher than those of the control group. Eosinophils infiltrated group had mean numbers of eosinophil of 89.8 cells/mm3 while control group's mean was 0.4 cells/mm2(p=0.005). Lymphocyte infiltrated group was 4 patients whose mean was 84.3 cells/mm2 with 28.4 cells/mm2 of control group(P=0.026). In addition, the mean thickness of the basement membrane of experimental group was 14.20 ± 5.20 μm in contrast of control group whose mean was 3.50 ± 1.37 μm(P=0.001). With the methacholine challenge test, 7 of the 21 eosinophil infiltrated subjects were diagnosed with cough variant asthma; the other 14 with eosinophilic bronchitis. Three subjects with eosinophilic bronchitis were atopic positive(21.4%) with the skin prick test. In the lymphocyte dominant group, all four subjects were diagnosed with lymphocytic bronchitis. Cough score was improved after steroid treatment in 22 of 25 subjects in the experimental group (88.0%). Conclusion: These results suggest chronic non-productive cough as an isolated symptom with a normal spirometry and chest radiograph was associated with airway inflammation by eosinophil and lymphocyte infiltration. The causes for chronic non-productive cough were eosinophilic bronchitis, cough variant asthma, and lymphocytic bronchitis(written in frequency). They further suggest that therapeutic treatment with steroids can provide effective symptomatic relief.

Original languageEnglish
Pages (from-to)372-385
Number of pages14
JournalTuberculosis and Respiratory Diseases
Volume46
Issue number3
Publication statusPublished - 1999 Jan 1

Fingerprint

Cough
Steroids
Eosinophils
Bronchitis
Biopsy
Thorax
Lymphocytes
Control Groups
Methacholine Chloride
Spirometry
Respiratory Function Tests
Skin Tests
Asthma
Lymphocyte Count
Bronchoscopy
Pathologic Processes
Prednisolone
Basement Membrane
Therapeutics
Inflammation

Keywords

  • Airway inflammation
  • Chronic cough
  • Cough variant asthma
  • Eosinophilic bronchitis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Sang Yeub Lee, Y. L., Hye Cheol Jeong, C. J., Kyung Kyu Kim, K. K., Kim, J. H., Young Hwan Kwan, H. K., Lee, S. Y., ... Kwang Ho In, H. I. (1999). The bronchial biopsies and steroid response in unexplained chronic non- productive cough. Tuberculosis and Respiratory Diseases, 46(3), 372-385.

The bronchial biopsies and steroid response in unexplained chronic non- productive cough. / Sang Yeub Lee, Yeub Lee; Hye Cheol Jeong, Cheol Jeong; Kyung Kyu Kim, Kyu Kim; Kim, Je Hyeong; Young Hwan Kwan, Hwan Kwan; Lee, Sung Yong; So Ra Lee, Ra Lee; Hyun Deuk Cho, Deuk Cho; Sin Hyung Lee, Hyung Lee; Jae Jeong Shim, Jeong Shim; Jae Yun Cho, Yun Cho; Han Gyum Kim, Gyum Kim; Kyung Ho Kang, Ho Kang; Se Hwa Yoo, Hwa Yoo; Kwang Ho In, Ho In.

In: Tuberculosis and Respiratory Diseases, Vol. 46, No. 3, 01.01.1999, p. 372-385.

Research output: Contribution to journalArticle

Sang Yeub Lee, YL, Hye Cheol Jeong, CJ, Kyung Kyu Kim, KK, Kim, JH, Young Hwan Kwan, HK, Lee, SY, So Ra Lee, RL, Hyun Deuk Cho, DC, Sin Hyung Lee, HL, Jae Jeong Shim, JS, Jae Yun Cho, YC, Han Gyum Kim, GK, Kyung Ho Kang, HK, Se Hwa Yoo, HY & Kwang Ho In, HI 1999, 'The bronchial biopsies and steroid response in unexplained chronic non- productive cough', Tuberculosis and Respiratory Diseases, vol. 46, no. 3, pp. 372-385.
Sang Yeub Lee YL, Hye Cheol Jeong CJ, Kyung Kyu Kim KK, Kim JH, Young Hwan Kwan HK, Lee SY et al. The bronchial biopsies and steroid response in unexplained chronic non- productive cough. Tuberculosis and Respiratory Diseases. 1999 Jan 1;46(3):372-385.
Sang Yeub Lee, Yeub Lee ; Hye Cheol Jeong, Cheol Jeong ; Kyung Kyu Kim, Kyu Kim ; Kim, Je Hyeong ; Young Hwan Kwan, Hwan Kwan ; Lee, Sung Yong ; So Ra Lee, Ra Lee ; Hyun Deuk Cho, Deuk Cho ; Sin Hyung Lee, Hyung Lee ; Jae Jeong Shim, Jeong Shim ; Jae Yun Cho, Yun Cho ; Han Gyum Kim, Gyum Kim ; Kyung Ho Kang, Ho Kang ; Se Hwa Yoo, Hwa Yoo ; Kwang Ho In, Ho In. / The bronchial biopsies and steroid response in unexplained chronic non- productive cough. In: Tuberculosis and Respiratory Diseases. 1999 ; Vol. 46, No. 3. pp. 372-385.
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AU - Jae Jeong Shim, Jeong Shim

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