The causative organisms of bacterial meningitis in Korean children in 1996-2005

Hye Kyung Cho, Hyunju Lee, Jin Han Kang, Kwang Nam Kim, Dong Soo Kim, Yun Kyung Kim, Jung Soo Kim, Jong Hyun Kim, Chang Hwi Kim, Hwang Min Kim, Su Eun Park, Sung Hee Oh, Eun Hee Chung, Sung Ho Cha, Young Youn Choi, Jae Kyun Hur, Young Jin Hong, Hoan Jong Lee, Kyung Hyo Kim

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Bacterial meningitis remains a serious cause of morbidity and mortality in childhood, despite the availability of effective vaccines against Haemophilus influenzae type b (Hib) or Streptococcus pneumoniae. The purpose of this study was to analyze data on bacterial meningitis cases in Korea from 1996 through 2005. The information of all hospitalized bacteria-proven meningitis cases was obtained from 17 university hospitals nationwide. A total of 402 cases were identified. Of these, 125 (29.9%) cases were neonates. Streptococcus agalactiae was the most common bacteria responsible for 99 (24.6%) of all cases regardless of age, followed by S. pneumoniae for 91 (22.6%) and H. influenzae for 67 (16.7%) patients. The common etiology beyond the neonatal period was S. pneumoniae for 91 (33.0%) followed by H. influenzae for 63 (22.8%) patients. The overall case fatality rate was 9.4%, which was similar with that in 1986-1995. In conclusion, S. agalactiae, S. pneumoniae and H. influenzae were important etiologic agents of bacterial meningitis in children in the last 10 yrs. It is required to establish the preventive strategy of the three bacteria. The nationwide epidemiologic study should be continued to evaluate immunization strategy and efficacy.

Original languageEnglish
Pages (from-to)895-899
Number of pages5
JournalJournal of Korean Medical Science
Volume25
Issue number6
DOIs
Publication statusPublished - 2010 Jun 1

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Bacterial Meningitides
Streptococcus pneumoniae
Haemophilus influenzae
Streptococcus agalactiae
Bacteria
Haemophilus influenzae type b
Mortality
Korea
Meningitis
Epidemiologic Studies
Immunization
Vaccines
Newborn Infant
Morbidity

Keywords

  • Bacterial
  • Epidemiology
  • Etiology
  • Haemophilus influenzae
  • Meningitis
  • Neisseria meningitidis
  • Streptococcus agalactiae
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The causative organisms of bacterial meningitis in Korean children in 1996-2005. / Cho, Hye Kyung; Lee, Hyunju; Kang, Jin Han; Kim, Kwang Nam; Kim, Dong Soo; Kim, Yun Kyung; Kim, Jung Soo; Kim, Jong Hyun; Kim, Chang Hwi; Kim, Hwang Min; Park, Su Eun; Oh, Sung Hee; Chung, Eun Hee; Cha, Sung Ho; Choi, Young Youn; Hur, Jae Kyun; Hong, Young Jin; Lee, Hoan Jong; Kim, Kyung Hyo.

In: Journal of Korean Medical Science, Vol. 25, No. 6, 01.06.2010, p. 895-899.

Research output: Contribution to journalArticle

Cho, HK, Lee, H, Kang, JH, Kim, KN, Kim, DS, Kim, YK, Kim, JS, Kim, JH, Kim, CH, Kim, HM, Park, SE, Oh, SH, Chung, EH, Cha, SH, Choi, YY, Hur, JK, Hong, YJ, Lee, HJ & Kim, KH 2010, 'The causative organisms of bacterial meningitis in Korean children in 1996-2005', Journal of Korean Medical Science, vol. 25, no. 6, pp. 895-899. https://doi.org/10.3346/jkms.2010.25.6.895
Cho, Hye Kyung ; Lee, Hyunju ; Kang, Jin Han ; Kim, Kwang Nam ; Kim, Dong Soo ; Kim, Yun Kyung ; Kim, Jung Soo ; Kim, Jong Hyun ; Kim, Chang Hwi ; Kim, Hwang Min ; Park, Su Eun ; Oh, Sung Hee ; Chung, Eun Hee ; Cha, Sung Ho ; Choi, Young Youn ; Hur, Jae Kyun ; Hong, Young Jin ; Lee, Hoan Jong ; Kim, Kyung Hyo. / The causative organisms of bacterial meningitis in Korean children in 1996-2005. In: Journal of Korean Medical Science. 2010 ; Vol. 25, No. 6. pp. 895-899.
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abstract = "Bacterial meningitis remains a serious cause of morbidity and mortality in childhood, despite the availability of effective vaccines against Haemophilus influenzae type b (Hib) or Streptococcus pneumoniae. The purpose of this study was to analyze data on bacterial meningitis cases in Korea from 1996 through 2005. The information of all hospitalized bacteria-proven meningitis cases was obtained from 17 university hospitals nationwide. A total of 402 cases were identified. Of these, 125 (29.9{\%}) cases were neonates. Streptococcus agalactiae was the most common bacteria responsible for 99 (24.6{\%}) of all cases regardless of age, followed by S. pneumoniae for 91 (22.6{\%}) and H. influenzae for 67 (16.7{\%}) patients. The common etiology beyond the neonatal period was S. pneumoniae for 91 (33.0{\%}) followed by H. influenzae for 63 (22.8{\%}) patients. The overall case fatality rate was 9.4{\%}, which was similar with that in 1986-1995. In conclusion, S. agalactiae, S. pneumoniae and H. influenzae were important etiologic agents of bacterial meningitis in children in the last 10 yrs. It is required to establish the preventive strategy of the three bacteria. The nationwide epidemiologic study should be continued to evaluate immunization strategy and efficacy.",
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AU - Kim, Yun Kyung

AU - Kim, Jung Soo

AU - Kim, Jong Hyun

AU - Kim, Chang Hwi

AU - Kim, Hwang Min

AU - Park, Su Eun

AU - Oh, Sung Hee

AU - Chung, Eun Hee

AU - Cha, Sung Ho

AU - Choi, Young Youn

AU - Hur, Jae Kyun

AU - Hong, Young Jin

AU - Lee, Hoan Jong

AU - Kim, Kyung Hyo

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N2 - Bacterial meningitis remains a serious cause of morbidity and mortality in childhood, despite the availability of effective vaccines against Haemophilus influenzae type b (Hib) or Streptococcus pneumoniae. The purpose of this study was to analyze data on bacterial meningitis cases in Korea from 1996 through 2005. The information of all hospitalized bacteria-proven meningitis cases was obtained from 17 university hospitals nationwide. A total of 402 cases were identified. Of these, 125 (29.9%) cases were neonates. Streptococcus agalactiae was the most common bacteria responsible for 99 (24.6%) of all cases regardless of age, followed by S. pneumoniae for 91 (22.6%) and H. influenzae for 67 (16.7%) patients. The common etiology beyond the neonatal period was S. pneumoniae for 91 (33.0%) followed by H. influenzae for 63 (22.8%) patients. The overall case fatality rate was 9.4%, which was similar with that in 1986-1995. In conclusion, S. agalactiae, S. pneumoniae and H. influenzae were important etiologic agents of bacterial meningitis in children in the last 10 yrs. It is required to establish the preventive strategy of the three bacteria. The nationwide epidemiologic study should be continued to evaluate immunization strategy and efficacy.

AB - Bacterial meningitis remains a serious cause of morbidity and mortality in childhood, despite the availability of effective vaccines against Haemophilus influenzae type b (Hib) or Streptococcus pneumoniae. The purpose of this study was to analyze data on bacterial meningitis cases in Korea from 1996 through 2005. The information of all hospitalized bacteria-proven meningitis cases was obtained from 17 university hospitals nationwide. A total of 402 cases were identified. Of these, 125 (29.9%) cases were neonates. Streptococcus agalactiae was the most common bacteria responsible for 99 (24.6%) of all cases regardless of age, followed by S. pneumoniae for 91 (22.6%) and H. influenzae for 67 (16.7%) patients. The common etiology beyond the neonatal period was S. pneumoniae for 91 (33.0%) followed by H. influenzae for 63 (22.8%) patients. The overall case fatality rate was 9.4%, which was similar with that in 1986-1995. In conclusion, S. agalactiae, S. pneumoniae and H. influenzae were important etiologic agents of bacterial meningitis in children in the last 10 yrs. It is required to establish the preventive strategy of the three bacteria. The nationwide epidemiologic study should be continued to evaluate immunization strategy and efficacy.

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