The chalcone derivative Chana 1 protects against amyloid β peptide-induced oxidative stress and cognitive impairment

Jieun Kwak, Mi Jeong Kim, Kyung Chul Choi, Hyo Kyung Choi, Woojin Jun, Hyun Jin Park, Yoo Hyun Lee, Ho Geun Yoon

Research output: Contribution to journalArticle

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease to cause dementia in the elderly. Amyloid β (Aβ)-peptide induced oxidative stress causes the initiation and progression of AD. Recently, new chalcone derivatives termed the Chana series were synthesized. Among them, Chana 1 showed high free radical scavenging activity (72.5%), as measured by a DPPH (1,1-diphenyl-2-picrylhydrazyl) assay. In this study, we investigated the effect of Chana 1 against Aβ-induced cytotoxicity and cognitive deficits. Additionally, we sought to estimate the lethal dose, 50% (LD 50) of Chana 1 in mice using an acute oral toxicity test. We found that Chana 1 significantly protected against Aβ-induced neuronal cell death in PC12 cells. Oral administration of Chana 1 at a dose of 50 mg/kg body weight/day significantly improved Aβ-induced learning and memory impairment in mice, as measured in Y-maze and passive avoidance tests. In acute toxicity tests, the LD 50 in mice was determined to be 520.44 mg/kg body weight. The data are valuable for future studies and suggest that Chana 1 has therapeutic potential for the management of neurodegenerative disease.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalInternational Journal of Molecular Medicine
Volume30
Issue number1
DOIs
Publication statusPublished - 2012 Jul 1

Fingerprint

Chalcone
Amyloid
Acute Toxicity Tests
Oxidative Stress
Lethal Dose 50
Neurodegenerative Diseases
Peptides
Alzheimer Disease
Body Weight
PC12 Cells
Free Radicals
Oral Administration
Dementia
Cell Death
Learning
Cognitive Dysfunction
Therapeutics

Keywords

  • β-amyloid
  • Alzheimer's disease
  • Chalcone derivative
  • Cognitive impairment
  • Lethal dose 50
  • Neuroprotective effect
  • Oxidative stress

ASJC Scopus subject areas

  • Genetics

Cite this

The chalcone derivative Chana 1 protects against amyloid β peptide-induced oxidative stress and cognitive impairment. / Kwak, Jieun; Kim, Mi Jeong; Choi, Kyung Chul; Choi, Hyo Kyung; Jun, Woojin; Park, Hyun Jin; Lee, Yoo Hyun; Yoon, Ho Geun.

In: International Journal of Molecular Medicine, Vol. 30, No. 1, 01.07.2012, p. 193-198.

Research output: Contribution to journalArticle

Kwak, Jieun ; Kim, Mi Jeong ; Choi, Kyung Chul ; Choi, Hyo Kyung ; Jun, Woojin ; Park, Hyun Jin ; Lee, Yoo Hyun ; Yoon, Ho Geun. / The chalcone derivative Chana 1 protects against amyloid β peptide-induced oxidative stress and cognitive impairment. In: International Journal of Molecular Medicine. 2012 ; Vol. 30, No. 1. pp. 193-198.
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