The chalcone derivative Chana 1 protects against amyloid β peptide-induced oxidative stress and cognitive impairment

Jieun Kwak, Mi Jeong Kim, Kyung Chul Choi, Hyo Kyung Choi, Woojin Jun, Hyun Jin Park, Yoo Hyun Lee, Ho Geun Yoon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease to cause dementia in the elderly. Amyloid β (Aβ)-peptide induced oxidative stress causes the initiation and progression of AD. Recently, new chalcone derivatives termed the Chana series were synthesized. Among them, Chana 1 showed high free radical scavenging activity (72.5%), as measured by a DPPH (1,1-diphenyl-2-picrylhydrazyl) assay. In this study, we investigated the effect of Chana 1 against Aβ-induced cytotoxicity and cognitive deficits. Additionally, we sought to estimate the lethal dose, 50% (LD 50) of Chana 1 in mice using an acute oral toxicity test. We found that Chana 1 significantly protected against Aβ-induced neuronal cell death in PC12 cells. Oral administration of Chana 1 at a dose of 50 mg/kg body weight/day significantly improved Aβ-induced learning and memory impairment in mice, as measured in Y-maze and passive avoidance tests. In acute toxicity tests, the LD 50 in mice was determined to be 520.44 mg/kg body weight. The data are valuable for future studies and suggest that Chana 1 has therapeutic potential for the management of neurodegenerative disease.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalInternational Journal of Molecular Medicine
Volume30
Issue number1
DOIs
Publication statusPublished - 2012 Jul 1

Keywords

  • β-amyloid
  • Alzheimer's disease
  • Chalcone derivative
  • Cognitive impairment
  • Lethal dose 50
  • Neuroprotective effect
  • Oxidative stress

ASJC Scopus subject areas

  • Genetics

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