@article{2320e573db194da5b8690b727f27ae13,
title = "The change in the nationwide seroprevalence of hepatitis C virus and the status of linkage to care in South Korea from 2009 to 2015",
abstract = "Background: Hepatitis C virus (HCV) requires epidemiological monitoring to estimate its disease burden and to develop countermeasures. This study aimed to investigate the difference between the 2015 and 2009 nationwide anti-HCV seroprevalence and to determine linkage to care estimates in South Korea. Methods: A total 268,422 examinees ≥ 20 years old were included in 2015 from 33 medical institutions nationwide. Electronically extracted data were retrospectively analyzed to calculate the age-, sex-, and area-adjusted anti-HCV prevalence. Seroprevalence in 2015 was measured using the same method as that in 2009. For anti-HCV-positive subjects, medical records were reviewed to see whether HCV RNA testing or antiviral treatment was performed. Results: Adjusted anti-HCV prevalence was 0.60% (95% confidence interval, 0.57–0.63) based on general Korean population in 2015. It showed an increasing trend according to age; 0.23% in thirties, 0.38% in forties, 0.63% in fifties, 1.08% in sixties, and 1.65% in those aged ≥ 70 years. From 2009 to 2015, the adjusted anti-HCV prevalence decreased by 30%, with odds ratio of 0.70 (95% CI 0.70–0.71). There was significant intranational regional variation and changing pattern of seroprevalence. Among 1359 anti-HCV-positive subjects, HCV RNA test was performed in 60% and 25.4% had positivity. Treatment-initiated and cured rates in 2015 were 18.5% and 10.9%, respectively. Conclusions: Anti-HCV prevalence in South Korea was 0.6% in 2015, showing a 30% decrease from that in 2009. Although the HCV RNA testing rate was increased since 2009, this remains suboptimal. Moreover, the treatment uptake rate should be improved in South Korea.",
keywords = "Anti-HCV, Antiviral treatment, Epidemiology, HCV RNA, Hepatitis C virus, Prevalence",
author = "{The Korean hepatitis epidemiology study group} and Jang, {Eun Sun} and Moran Ki and Choi, {Hwa Young} and Kim, {Kyung Ah} and Jeong, {Sook Hyang} and Kim, {Gi Ae} and Kim, {Do Young} and Kim, {Dong Joon} and Kim, {Man Woo} and Kim, {Sung Eun} and Kim, {Yun Soo} and Kim, {Young Seok} and Kim, {In Hee} and Kim, {Chang Wook} and Kim, {Ho Dong} and Kim, {Hyung Joon} and Park, {Neung Hwa} and Baik, {Soon Koo} and Suh, {Jeong Ill} and Song, {Byung Cheol} and Song, {Il Han} and Yeon, {Jong Eun} and Lee, {Byung Seok} and Lee, {Youn Jae} and Jung, {Young Kul} and Chung, {Woo Jin} and Cho, {Sung Bum} and Cho, {Eun Young} and Cho, {Hyun Chin} and Cheon, {Gab Jin} and Chae, {Hee Bok} and Choi, {Dae Hee} and Choi, {Sung Kyu} and Tak, {Won Young} and Jeong Heo and Jeong, {Sook Hyang}",
note = "Funding Information: This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare (Grant number: HC15C1193) and by a grant of the Chronic Infectious Disease Cohort Study (Korea HCV Cohort Study, 4800-4859-304) from the Korea Centers for Disease Control, Republic of Korea. The Korean hepatitis epidemiology study group included: Eun Sun Jang: Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Moran Ki: Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Gyeonggi, Geum-Youn Gwak: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Kyung-Ah Kim: Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Gyeonggi, Gi-Ae Kim: Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul. Do Young Kim: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Dong Joon Kim: Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Gangwon, Man Woo Kim: Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Sung Eun Kim: Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Gyeonggi, Yun Soo Kim: Department of Internal Medicine, Gachon College of Medicine, Incheon, Young Seok Kim: Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Gyeonggi, In Hee Kim: Department of Internal Medicine, Chonbuk National University Hopital, Chonbuk National University College of Medicine, Chonju, Republic of Korea, Chang Wook Kim: Department of Internal Medicine, Uijeongbu St.Mary{\textquoteright}s Hospital, Catholic University College of Medicine, Uijeongbu, Gyeonggi, Ho Dong Kim: Department of Internal Medicine, St.Carollo General Hospital, Suncheon, Jeonnam, Hyung Joon Kim: Department of Internal Medicine, Chung-Ang University Hospital, Chungang University College of Medicine, Seoul, Neung Hwa Park: Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Soon Koo Baik: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon, Jeong Ill Suh: Department of Internal Medicine, Dongguk University Gyeongju Hospital, Dongguk University College of Medicine, Gyeongju, Gyeongbuk, Byung-Cheol Song: Department of Internal Medicine, Jeju National University College of Medicine, Jeju, Il Han Song: Department of Internal Medicine, Dankook University Hospital, Cheonan, Chungnam, Jong Eun Yeon: Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Byung Seok Lee: Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea, Youn Jae Lee: Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea, Young Kul Jung: Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Gyeonggi, Woo Jin Chung: Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Sung Bum Cho: Department of Internal Medicine, Chonnam National University Hwasun Hospital, Jeonnam, Eun-Young Cho: Department of Internal Medicine, Wonkwang University College of Medicine, Iksan, Jeonbuk, Hyun Chin Cho: Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Gyeongnam, Gab Jin Cheon: Department of Internal Medicine, GangNeung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Gangwon, Hee Bok Chae: Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Chungbuk, Dae Hee Choi: Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Gangwon, Sung-Kyu Choi: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Hwa Young Choi: Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Gyeonggi, Won Young Tak: Department of Internal Medicine, Kyungpook National University College of Medicine, Daegu, Jeong Heo: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Sook-Hyang Jeong: Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi. Publisher Copyright: {\textcopyright} 2019, Asian Pacific Association for the Study of the Liver.",
year = "2019",
month = sep,
day = "1",
doi = "10.1007/s12072-019-09975-y",
language = "English",
volume = "13",
pages = "599--608",
journal = "Hepatology International",
issn = "1936-0533",
publisher = "Springer New York",
number = "5",
}