The change of macular thickness measured by optical coherence tomography in relation to glycemic control in diabetic patients

Sang Woong Moon, Hee Young Kim, Seong-Woo Kim, Jae Ryung Oh, Kuhl Huh, In Kyung Oh

Research output: Contribution to journalArticle

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Abstract

Background: To demonstrate the change in macular thickness using optical coherence tomography in diabetic patients and to assess its relationship with glycosylated hemoglobin (HbA1c) levels. Methods: Diabetic patients who underwent at least two macular thickness measurements with OCT within a 12-month period were included. HbA1c values within 1 month of each OCT study, and clinical data such as age, insulin treatment, systemic hypertension, and the severity of diabetic retinopathy were collected. The change in three macula parameters including center point thickness (CPT), central subfoveal macular thickness (CSMT), and total macular volume (TMV) between two measurements was calculated. Patients were divided into two groups based on the half-width of the 95% confidence interval for percent change, the increase group (group 1) and the decrease group (group 2). The associations of CPT change, CSMT change, and TMV change with baseline HbA1c levels, HbA1c change, and other clinical factors were investigated using correlation analysis and group comparison. Results: A total of 23 eyes of 23 patients were studied. In correlation analysis; the increase in CPT, CSMT, and TMV was correlated with baseline HbA1c (CPT, Spearman's rho=0.462, p=0.027; CSMT, Spearman's rho=0.479, p=0.021; TMV, Spearman's rho=0.589, p=0.003), and the change of HbA1c (CPT, Spearman's rho=-0.585, p=0.003; CSMT, Spearman's rho=-0.583, p=0.004; TMV, Spearman's rho=-0.725, p<0.001). In group comparison for CPT, group 1 have a higher baseline HbA1c (11.2% vs 8.7% of THb, p=0.044) and a greater HbA1c reduction (-3.3% vs -1.2% of THb, p=0.044) than group 2. For CSMT, group 1 tended to have a greater HbA1c reduction (-2.9% vs -1.2% of THb, p=0.074) than group 2. For TMV, group 1 had a higher baseline HbA1c (11.6% vs 8.4% of THb, p=0.001) and a greater HbA1c reduction (-3.5% vs -0.5% of THb, p<0.001) than group 2. Conclusions: The change in macular thickness and volume developed in relation to HbA1c levels during a less than 12-month period. A high baseline HbA1c and a large reduction of HbA1c were risk factors for the increase in macular thickness. Prospective study with a large number of patients is needed to clarify the change of macular thickness in relation to glycemic control.

Original languageEnglish
Pages (from-to)839-848
Number of pages10
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume249
Issue number6
DOIs
Publication statusPublished - 2011 Jun 1

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Optical Coherence Tomography
Glycosylated Hemoglobin A
Diabetic Retinopathy
Prospective Studies
Confidence Intervals
Insulin
Hypertension

Keywords

  • Diabetic macular edema
  • Glycosylated hemoglobin
  • Optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

The change of macular thickness measured by optical coherence tomography in relation to glycemic control in diabetic patients. / Moon, Sang Woong; Kim, Hee Young; Kim, Seong-Woo; Oh, Jae Ryung; Huh, Kuhl; Oh, In Kyung.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 249, No. 6, 01.06.2011, p. 839-848.

Research output: Contribution to journalArticle

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abstract = "Background: To demonstrate the change in macular thickness using optical coherence tomography in diabetic patients and to assess its relationship with glycosylated hemoglobin (HbA1c) levels. Methods: Diabetic patients who underwent at least two macular thickness measurements with OCT within a 12-month period were included. HbA1c values within 1 month of each OCT study, and clinical data such as age, insulin treatment, systemic hypertension, and the severity of diabetic retinopathy were collected. The change in three macula parameters including center point thickness (CPT), central subfoveal macular thickness (CSMT), and total macular volume (TMV) between two measurements was calculated. Patients were divided into two groups based on the half-width of the 95{\%} confidence interval for percent change, the increase group (group 1) and the decrease group (group 2). The associations of CPT change, CSMT change, and TMV change with baseline HbA1c levels, HbA1c change, and other clinical factors were investigated using correlation analysis and group comparison. Results: A total of 23 eyes of 23 patients were studied. In correlation analysis; the increase in CPT, CSMT, and TMV was correlated with baseline HbA1c (CPT, Spearman's rho=0.462, p=0.027; CSMT, Spearman's rho=0.479, p=0.021; TMV, Spearman's rho=0.589, p=0.003), and the change of HbA1c (CPT, Spearman's rho=-0.585, p=0.003; CSMT, Spearman's rho=-0.583, p=0.004; TMV, Spearman's rho=-0.725, p<0.001). In group comparison for CPT, group 1 have a higher baseline HbA1c (11.2{\%} vs 8.7{\%} of THb, p=0.044) and a greater HbA1c reduction (-3.3{\%} vs -1.2{\%} of THb, p=0.044) than group 2. For CSMT, group 1 tended to have a greater HbA1c reduction (-2.9{\%} vs -1.2{\%} of THb, p=0.074) than group 2. For TMV, group 1 had a higher baseline HbA1c (11.6{\%} vs 8.4{\%} of THb, p=0.001) and a greater HbA1c reduction (-3.5{\%} vs -0.5{\%} of THb, p<0.001) than group 2. Conclusions: The change in macular thickness and volume developed in relation to HbA1c levels during a less than 12-month period. A high baseline HbA1c and a large reduction of HbA1c were risk factors for the increase in macular thickness. Prospective study with a large number of patients is needed to clarify the change of macular thickness in relation to glycemic control.",
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T1 - The change of macular thickness measured by optical coherence tomography in relation to glycemic control in diabetic patients

AU - Moon, Sang Woong

AU - Kim, Hee Young

AU - Kim, Seong-Woo

AU - Oh, Jae Ryung

AU - Huh, Kuhl

AU - Oh, In Kyung

PY - 2011/6/1

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N2 - Background: To demonstrate the change in macular thickness using optical coherence tomography in diabetic patients and to assess its relationship with glycosylated hemoglobin (HbA1c) levels. Methods: Diabetic patients who underwent at least two macular thickness measurements with OCT within a 12-month period were included. HbA1c values within 1 month of each OCT study, and clinical data such as age, insulin treatment, systemic hypertension, and the severity of diabetic retinopathy were collected. The change in three macula parameters including center point thickness (CPT), central subfoveal macular thickness (CSMT), and total macular volume (TMV) between two measurements was calculated. Patients were divided into two groups based on the half-width of the 95% confidence interval for percent change, the increase group (group 1) and the decrease group (group 2). The associations of CPT change, CSMT change, and TMV change with baseline HbA1c levels, HbA1c change, and other clinical factors were investigated using correlation analysis and group comparison. Results: A total of 23 eyes of 23 patients were studied. In correlation analysis; the increase in CPT, CSMT, and TMV was correlated with baseline HbA1c (CPT, Spearman's rho=0.462, p=0.027; CSMT, Spearman's rho=0.479, p=0.021; TMV, Spearman's rho=0.589, p=0.003), and the change of HbA1c (CPT, Spearman's rho=-0.585, p=0.003; CSMT, Spearman's rho=-0.583, p=0.004; TMV, Spearman's rho=-0.725, p<0.001). In group comparison for CPT, group 1 have a higher baseline HbA1c (11.2% vs 8.7% of THb, p=0.044) and a greater HbA1c reduction (-3.3% vs -1.2% of THb, p=0.044) than group 2. For CSMT, group 1 tended to have a greater HbA1c reduction (-2.9% vs -1.2% of THb, p=0.074) than group 2. For TMV, group 1 had a higher baseline HbA1c (11.6% vs 8.4% of THb, p=0.001) and a greater HbA1c reduction (-3.5% vs -0.5% of THb, p<0.001) than group 2. Conclusions: The change in macular thickness and volume developed in relation to HbA1c levels during a less than 12-month period. A high baseline HbA1c and a large reduction of HbA1c were risk factors for the increase in macular thickness. Prospective study with a large number of patients is needed to clarify the change of macular thickness in relation to glycemic control.

AB - Background: To demonstrate the change in macular thickness using optical coherence tomography in diabetic patients and to assess its relationship with glycosylated hemoglobin (HbA1c) levels. Methods: Diabetic patients who underwent at least two macular thickness measurements with OCT within a 12-month period were included. HbA1c values within 1 month of each OCT study, and clinical data such as age, insulin treatment, systemic hypertension, and the severity of diabetic retinopathy were collected. The change in three macula parameters including center point thickness (CPT), central subfoveal macular thickness (CSMT), and total macular volume (TMV) between two measurements was calculated. Patients were divided into two groups based on the half-width of the 95% confidence interval for percent change, the increase group (group 1) and the decrease group (group 2). The associations of CPT change, CSMT change, and TMV change with baseline HbA1c levels, HbA1c change, and other clinical factors were investigated using correlation analysis and group comparison. Results: A total of 23 eyes of 23 patients were studied. In correlation analysis; the increase in CPT, CSMT, and TMV was correlated with baseline HbA1c (CPT, Spearman's rho=0.462, p=0.027; CSMT, Spearman's rho=0.479, p=0.021; TMV, Spearman's rho=0.589, p=0.003), and the change of HbA1c (CPT, Spearman's rho=-0.585, p=0.003; CSMT, Spearman's rho=-0.583, p=0.004; TMV, Spearman's rho=-0.725, p<0.001). In group comparison for CPT, group 1 have a higher baseline HbA1c (11.2% vs 8.7% of THb, p=0.044) and a greater HbA1c reduction (-3.3% vs -1.2% of THb, p=0.044) than group 2. For CSMT, group 1 tended to have a greater HbA1c reduction (-2.9% vs -1.2% of THb, p=0.074) than group 2. For TMV, group 1 had a higher baseline HbA1c (11.6% vs 8.4% of THb, p=0.001) and a greater HbA1c reduction (-3.5% vs -0.5% of THb, p<0.001) than group 2. Conclusions: The change in macular thickness and volume developed in relation to HbA1c levels during a less than 12-month period. A high baseline HbA1c and a large reduction of HbA1c were risk factors for the increase in macular thickness. Prospective study with a large number of patients is needed to clarify the change of macular thickness in relation to glycemic control.

KW - Diabetic macular edema

KW - Glycosylated hemoglobin

KW - Optical coherence tomography

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