The clinical and histopathological study of Ota's nevus

Seung Hyun Chun, Sanghoon Lee, Hana Park, Su Young Jhun, In Bum Sohn, Hak Yong Kim, Eung Ho Choi, Sang Min Hwang, Seung Hun Lee, Joong Gie Kim, Seong Jun Seo, Joo Heung Lee, Hyun Chung, Sang Won Kim, Jeong Deuk Lee, Young Min Park, Hyung Ok Kim, Bo Kyung Koh, Il-Hwan Kim, Soo Nam Kim & 8 others Seok Jong Lee, You Chan Kim, Mi Woo Lee, Jai Kyoung Koh, Kwang Ho Kim, Sang Tae Kim, Kee Suck Suh, Sung Ku Ahn

Research output: Contribution to journalArticle

Abstract

Background: Ota's nevus, characterized by the presence of melanocytes in the dermis, has been familiar among dermatologists, but the etiology, the pathophysiology, the clinical and histological classification are not entirely clear. To understand and elucidate them, more clinical studies and researches are necessary. Object: The aim of this study was to document the clinical and histopathological features of Ota's nevus. Methods: We examined 299 patients with Ota's nevus who visited the dermatology clinic in Korea from February 1993 to August 2003. Among them, 188 patients were biopsied. All the specimens were stained with hematoxylin and eosin. We examined the age & sex distribution, age of onset, seasonal variation, associated skin diseases, aggravating factors and color. We clinically classified Ota's nevus into 4 types according to Tanino's classification and histologically into 5 types based on the pattern of pigmentation. Results: 1. The ratio of male and female was 1:3. 2. The peak age of onset was at birth (28.4%) and puberty (24.8%). 3. Seasonal variation was observed with distinct aggravation in the summer (60%). 4. The associated diseases were 9 cases of persistent mongolian spot, 6 cases of nevus flameus, 4 cases of blue nevus, 3 cases of vitiligo, 3 cases of nevus of Ito, 2 cases of atopic dermatitis, 2 cases of psoriasis, 2 cases of cafe au late macules and 2 cases of contact dermatitis. 5. The aggravating factors were sunlight (35.8%), emotional stress (21.0%), menstruation (12.6%), cold exposure (9.5%), pregnancy (9.5%), fatigue (9.5%) and chemical agents (2.1%). 6. The color of lesions were blue black (36.8%), brown (34.8%), dark brown (16.1%) and slate (11.0%). 7. All cases were classified according to Tanino's methods: type Ia (23.1%), type Ib (20.1%), type II (26.7%), type III (9.4%), type IV (20.7%). 8. The histological subtypes of Ota's nevus were classified as: the superficial type (35.6%); the middermis type (5.9%), the superficial-middermis type (18.6%); the mid-lower dermis type (2.7%); the diffuse type was composed of the superficial dominant type (19.7%), the middermis dominant type (4.8%), the dispersed (true diffuse) type (12.2%) and the deep dominant type (0.5%). 9. In the relation between histological types and the color of the lesion: the superficial type had 31 cases of brown color, 15 cases of blue black color, 11 cases of dark brown color and 9 cases of slate color; the middermis type had 6 cases of blue black color and 2 cases of dark brown color, query number of cases of slate color; the superficial-middermis type had 12 cases of blue black color, 10 cases of dark brown color, 7 cases of brown color and 6 cases of slate color: the mid-lower dermis type had 3 cases of blue black color; for the diffuse type, the superficial dominant type had 13 cases of brown color, query number of cases of blue black color and 7 cases of dark brown color; the mid-dermis dominant type had 4 cases of brown color, query number of cases of dark brown color, the dispersed type had 14 cases of blue black color and 5 cases of brown color; the deep dominant type had 1 case of blue black color. Conclusion: The histological reclassification of Ota's nevus may be very useful in making a therapeutic prognosis of the disease.

Original languageEnglish
Pages (from-to)272-280
Number of pages9
JournalKorean Journal of Dermatology
Volume42
Issue number3
Publication statusPublished - 2004 Mar 1

Fingerprint

Nevus of Ota
Color
Dermis
Clinical Studies
Nevus
Age of Onset

Keywords

  • Clinical & histopathological study
  • Ota's nevus

ASJC Scopus subject areas

  • Dermatology

Cite this

Chun, S. H., Lee, S., Park, H., Jhun, S. Y., Sohn, I. B., Kim, H. Y., ... Ahn, S. K. (2004). The clinical and histopathological study of Ota's nevus. Korean Journal of Dermatology, 42(3), 272-280.

The clinical and histopathological study of Ota's nevus. / Chun, Seung Hyun; Lee, Sanghoon; Park, Hana; Jhun, Su Young; Sohn, In Bum; Kim, Hak Yong; Choi, Eung Ho; Hwang, Sang Min; Lee, Seung Hun; Kim, Joong Gie; Seo, Seong Jun; Lee, Joo Heung; Chung, Hyun; Kim, Sang Won; Lee, Jeong Deuk; Park, Young Min; Kim, Hyung Ok; Koh, Bo Kyung; Kim, Il-Hwan; Kim, Soo Nam; Lee, Seok Jong; Kim, You Chan; Lee, Mi Woo; Koh, Jai Kyoung; Kim, Kwang Ho; Kim, Sang Tae; Suh, Kee Suck; Ahn, Sung Ku.

In: Korean Journal of Dermatology, Vol. 42, No. 3, 01.03.2004, p. 272-280.

Research output: Contribution to journalArticle

Chun, SH, Lee, S, Park, H, Jhun, SY, Sohn, IB, Kim, HY, Choi, EH, Hwang, SM, Lee, SH, Kim, JG, Seo, SJ, Lee, JH, Chung, H, Kim, SW, Lee, JD, Park, YM, Kim, HO, Koh, BK, Kim, I-H, Kim, SN, Lee, SJ, Kim, YC, Lee, MW, Koh, JK, Kim, KH, Kim, ST, Suh, KS & Ahn, SK 2004, 'The clinical and histopathological study of Ota's nevus', Korean Journal of Dermatology, vol. 42, no. 3, pp. 272-280.
Chun SH, Lee S, Park H, Jhun SY, Sohn IB, Kim HY et al. The clinical and histopathological study of Ota's nevus. Korean Journal of Dermatology. 2004 Mar 1;42(3):272-280.
Chun, Seung Hyun ; Lee, Sanghoon ; Park, Hana ; Jhun, Su Young ; Sohn, In Bum ; Kim, Hak Yong ; Choi, Eung Ho ; Hwang, Sang Min ; Lee, Seung Hun ; Kim, Joong Gie ; Seo, Seong Jun ; Lee, Joo Heung ; Chung, Hyun ; Kim, Sang Won ; Lee, Jeong Deuk ; Park, Young Min ; Kim, Hyung Ok ; Koh, Bo Kyung ; Kim, Il-Hwan ; Kim, Soo Nam ; Lee, Seok Jong ; Kim, You Chan ; Lee, Mi Woo ; Koh, Jai Kyoung ; Kim, Kwang Ho ; Kim, Sang Tae ; Suh, Kee Suck ; Ahn, Sung Ku. / The clinical and histopathological study of Ota's nevus. In: Korean Journal of Dermatology. 2004 ; Vol. 42, No. 3. pp. 272-280.
@article{a72527f3c88b4f5fa246cda04fd52feb,
title = "The clinical and histopathological study of Ota's nevus",
abstract = "Background: Ota's nevus, characterized by the presence of melanocytes in the dermis, has been familiar among dermatologists, but the etiology, the pathophysiology, the clinical and histological classification are not entirely clear. To understand and elucidate them, more clinical studies and researches are necessary. Object: The aim of this study was to document the clinical and histopathological features of Ota's nevus. Methods: We examined 299 patients with Ota's nevus who visited the dermatology clinic in Korea from February 1993 to August 2003. Among them, 188 patients were biopsied. All the specimens were stained with hematoxylin and eosin. We examined the age & sex distribution, age of onset, seasonal variation, associated skin diseases, aggravating factors and color. We clinically classified Ota's nevus into 4 types according to Tanino's classification and histologically into 5 types based on the pattern of pigmentation. Results: 1. The ratio of male and female was 1:3. 2. The peak age of onset was at birth (28.4{\%}) and puberty (24.8{\%}). 3. Seasonal variation was observed with distinct aggravation in the summer (60{\%}). 4. The associated diseases were 9 cases of persistent mongolian spot, 6 cases of nevus flameus, 4 cases of blue nevus, 3 cases of vitiligo, 3 cases of nevus of Ito, 2 cases of atopic dermatitis, 2 cases of psoriasis, 2 cases of cafe au late macules and 2 cases of contact dermatitis. 5. The aggravating factors were sunlight (35.8{\%}), emotional stress (21.0{\%}), menstruation (12.6{\%}), cold exposure (9.5{\%}), pregnancy (9.5{\%}), fatigue (9.5{\%}) and chemical agents (2.1{\%}). 6. The color of lesions were blue black (36.8{\%}), brown (34.8{\%}), dark brown (16.1{\%}) and slate (11.0{\%}). 7. All cases were classified according to Tanino's methods: type Ia (23.1{\%}), type Ib (20.1{\%}), type II (26.7{\%}), type III (9.4{\%}), type IV (20.7{\%}). 8. The histological subtypes of Ota's nevus were classified as: the superficial type (35.6{\%}); the middermis type (5.9{\%}), the superficial-middermis type (18.6{\%}); the mid-lower dermis type (2.7{\%}); the diffuse type was composed of the superficial dominant type (19.7{\%}), the middermis dominant type (4.8{\%}), the dispersed (true diffuse) type (12.2{\%}) and the deep dominant type (0.5{\%}). 9. In the relation between histological types and the color of the lesion: the superficial type had 31 cases of brown color, 15 cases of blue black color, 11 cases of dark brown color and 9 cases of slate color; the middermis type had 6 cases of blue black color and 2 cases of dark brown color, query number of cases of slate color; the superficial-middermis type had 12 cases of blue black color, 10 cases of dark brown color, 7 cases of brown color and 6 cases of slate color: the mid-lower dermis type had 3 cases of blue black color; for the diffuse type, the superficial dominant type had 13 cases of brown color, query number of cases of blue black color and 7 cases of dark brown color; the mid-dermis dominant type had 4 cases of brown color, query number of cases of dark brown color, the dispersed type had 14 cases of blue black color and 5 cases of brown color; the deep dominant type had 1 case of blue black color. Conclusion: The histological reclassification of Ota's nevus may be very useful in making a therapeutic prognosis of the disease.",
keywords = "Clinical & histopathological study, Ota's nevus",
author = "Chun, {Seung Hyun} and Sanghoon Lee and Hana Park and Jhun, {Su Young} and Sohn, {In Bum} and Kim, {Hak Yong} and Choi, {Eung Ho} and Hwang, {Sang Min} and Lee, {Seung Hun} and Kim, {Joong Gie} and Seo, {Seong Jun} and Lee, {Joo Heung} and Hyun Chung and Kim, {Sang Won} and Lee, {Jeong Deuk} and Park, {Young Min} and Kim, {Hyung Ok} and Koh, {Bo Kyung} and Il-Hwan Kim and Kim, {Soo Nam} and Lee, {Seok Jong} and Kim, {You Chan} and Lee, {Mi Woo} and Koh, {Jai Kyoung} and Kim, {Kwang Ho} and Kim, {Sang Tae} and Suh, {Kee Suck} and Ahn, {Sung Ku}",
year = "2004",
month = "3",
day = "1",
language = "English",
volume = "42",
pages = "272--280",
journal = "Korean Journal of Dermatology",
issn = "0494-4739",
publisher = "Korean Dermatological Association",
number = "3",

}

TY - JOUR

T1 - The clinical and histopathological study of Ota's nevus

AU - Chun, Seung Hyun

AU - Lee, Sanghoon

AU - Park, Hana

AU - Jhun, Su Young

AU - Sohn, In Bum

AU - Kim, Hak Yong

AU - Choi, Eung Ho

AU - Hwang, Sang Min

AU - Lee, Seung Hun

AU - Kim, Joong Gie

AU - Seo, Seong Jun

AU - Lee, Joo Heung

AU - Chung, Hyun

AU - Kim, Sang Won

AU - Lee, Jeong Deuk

AU - Park, Young Min

AU - Kim, Hyung Ok

AU - Koh, Bo Kyung

AU - Kim, Il-Hwan

AU - Kim, Soo Nam

AU - Lee, Seok Jong

AU - Kim, You Chan

AU - Lee, Mi Woo

AU - Koh, Jai Kyoung

AU - Kim, Kwang Ho

AU - Kim, Sang Tae

AU - Suh, Kee Suck

AU - Ahn, Sung Ku

PY - 2004/3/1

Y1 - 2004/3/1

N2 - Background: Ota's nevus, characterized by the presence of melanocytes in the dermis, has been familiar among dermatologists, but the etiology, the pathophysiology, the clinical and histological classification are not entirely clear. To understand and elucidate them, more clinical studies and researches are necessary. Object: The aim of this study was to document the clinical and histopathological features of Ota's nevus. Methods: We examined 299 patients with Ota's nevus who visited the dermatology clinic in Korea from February 1993 to August 2003. Among them, 188 patients were biopsied. All the specimens were stained with hematoxylin and eosin. We examined the age & sex distribution, age of onset, seasonal variation, associated skin diseases, aggravating factors and color. We clinically classified Ota's nevus into 4 types according to Tanino's classification and histologically into 5 types based on the pattern of pigmentation. Results: 1. The ratio of male and female was 1:3. 2. The peak age of onset was at birth (28.4%) and puberty (24.8%). 3. Seasonal variation was observed with distinct aggravation in the summer (60%). 4. The associated diseases were 9 cases of persistent mongolian spot, 6 cases of nevus flameus, 4 cases of blue nevus, 3 cases of vitiligo, 3 cases of nevus of Ito, 2 cases of atopic dermatitis, 2 cases of psoriasis, 2 cases of cafe au late macules and 2 cases of contact dermatitis. 5. The aggravating factors were sunlight (35.8%), emotional stress (21.0%), menstruation (12.6%), cold exposure (9.5%), pregnancy (9.5%), fatigue (9.5%) and chemical agents (2.1%). 6. The color of lesions were blue black (36.8%), brown (34.8%), dark brown (16.1%) and slate (11.0%). 7. All cases were classified according to Tanino's methods: type Ia (23.1%), type Ib (20.1%), type II (26.7%), type III (9.4%), type IV (20.7%). 8. The histological subtypes of Ota's nevus were classified as: the superficial type (35.6%); the middermis type (5.9%), the superficial-middermis type (18.6%); the mid-lower dermis type (2.7%); the diffuse type was composed of the superficial dominant type (19.7%), the middermis dominant type (4.8%), the dispersed (true diffuse) type (12.2%) and the deep dominant type (0.5%). 9. In the relation between histological types and the color of the lesion: the superficial type had 31 cases of brown color, 15 cases of blue black color, 11 cases of dark brown color and 9 cases of slate color; the middermis type had 6 cases of blue black color and 2 cases of dark brown color, query number of cases of slate color; the superficial-middermis type had 12 cases of blue black color, 10 cases of dark brown color, 7 cases of brown color and 6 cases of slate color: the mid-lower dermis type had 3 cases of blue black color; for the diffuse type, the superficial dominant type had 13 cases of brown color, query number of cases of blue black color and 7 cases of dark brown color; the mid-dermis dominant type had 4 cases of brown color, query number of cases of dark brown color, the dispersed type had 14 cases of blue black color and 5 cases of brown color; the deep dominant type had 1 case of blue black color. Conclusion: The histological reclassification of Ota's nevus may be very useful in making a therapeutic prognosis of the disease.

AB - Background: Ota's nevus, characterized by the presence of melanocytes in the dermis, has been familiar among dermatologists, but the etiology, the pathophysiology, the clinical and histological classification are not entirely clear. To understand and elucidate them, more clinical studies and researches are necessary. Object: The aim of this study was to document the clinical and histopathological features of Ota's nevus. Methods: We examined 299 patients with Ota's nevus who visited the dermatology clinic in Korea from February 1993 to August 2003. Among them, 188 patients were biopsied. All the specimens were stained with hematoxylin and eosin. We examined the age & sex distribution, age of onset, seasonal variation, associated skin diseases, aggravating factors and color. We clinically classified Ota's nevus into 4 types according to Tanino's classification and histologically into 5 types based on the pattern of pigmentation. Results: 1. The ratio of male and female was 1:3. 2. The peak age of onset was at birth (28.4%) and puberty (24.8%). 3. Seasonal variation was observed with distinct aggravation in the summer (60%). 4. The associated diseases were 9 cases of persistent mongolian spot, 6 cases of nevus flameus, 4 cases of blue nevus, 3 cases of vitiligo, 3 cases of nevus of Ito, 2 cases of atopic dermatitis, 2 cases of psoriasis, 2 cases of cafe au late macules and 2 cases of contact dermatitis. 5. The aggravating factors were sunlight (35.8%), emotional stress (21.0%), menstruation (12.6%), cold exposure (9.5%), pregnancy (9.5%), fatigue (9.5%) and chemical agents (2.1%). 6. The color of lesions were blue black (36.8%), brown (34.8%), dark brown (16.1%) and slate (11.0%). 7. All cases were classified according to Tanino's methods: type Ia (23.1%), type Ib (20.1%), type II (26.7%), type III (9.4%), type IV (20.7%). 8. The histological subtypes of Ota's nevus were classified as: the superficial type (35.6%); the middermis type (5.9%), the superficial-middermis type (18.6%); the mid-lower dermis type (2.7%); the diffuse type was composed of the superficial dominant type (19.7%), the middermis dominant type (4.8%), the dispersed (true diffuse) type (12.2%) and the deep dominant type (0.5%). 9. In the relation between histological types and the color of the lesion: the superficial type had 31 cases of brown color, 15 cases of blue black color, 11 cases of dark brown color and 9 cases of slate color; the middermis type had 6 cases of blue black color and 2 cases of dark brown color, query number of cases of slate color; the superficial-middermis type had 12 cases of blue black color, 10 cases of dark brown color, 7 cases of brown color and 6 cases of slate color: the mid-lower dermis type had 3 cases of blue black color; for the diffuse type, the superficial dominant type had 13 cases of brown color, query number of cases of blue black color and 7 cases of dark brown color; the mid-dermis dominant type had 4 cases of brown color, query number of cases of dark brown color, the dispersed type had 14 cases of blue black color and 5 cases of brown color; the deep dominant type had 1 case of blue black color. Conclusion: The histological reclassification of Ota's nevus may be very useful in making a therapeutic prognosis of the disease.

KW - Clinical & histopathological study

KW - Ota's nevus

UR - http://www.scopus.com/inward/record.url?scp=2642559662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2642559662&partnerID=8YFLogxK

M3 - Article

VL - 42

SP - 272

EP - 280

JO - Korean Journal of Dermatology

JF - Korean Journal of Dermatology

SN - 0494-4739

IS - 3

ER -