The clinical use of low-dose multidetector row computed tomography for breast cancer patients in the prone position

Woo Jin Lee, Bo Kyoung Seo, Pyung Kon Cho, Ann Yie, Kyu Ran Cho, Ok Hee Woo, Sang Hoon Cha, Gil Soo Son, Guen Young Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To investigate the clinical use of low-dose multidetector row computed tomography (MDCT) for staging of invasive breast cancers with patients in the prone position. Methods: Three hundred twenty-two patients with 334 pathologically-verified breast cancers had low-dose MDCT breast imaging in the prone position for tumor staging before treatment between May 2006 and June 2010. We designed an additional computed tomography table pad with a hole for prone positioning. Patients lay prone on the table pad and the breasts were positioned within the rectangular hole. We obtained dynamic breast imaging from the lower neck to the lung base with the following parameters: 120 kVp, 50 mAs, and 3-mm reconstruction intervals. We evaluated the extent of the primary tumor, lymph nodal status, and distant metastasis in lung or bone, then assessed tumor staging based on the TNM classification of breast cancer. The assessed staging compared to the pathologic results for diagnostic accuracy. Results: Among the 334 invasive breast cancers, the overall diagnostic accuracy of tumor staging was 88.3% and the accuracy values of each tumor stage were 89.6% in T1, 90.8% in T2, 81.0% in T3, and 89.3% in T4. The overall diagnostic accuracy of lymph nodal staging was 86.3% and the accuracy values in each nodal stage were 82.9% in N0, 88.0% in N1, 89.7% in N2, and 93.3% in N3. Based on breast computed tomography scans, we detected distant metastases in 30 cases (7 lungs, 10 bones, 7 lungs and bones, and 6 livers). Conclusion: Lowdose MDCT scanning for invasive breast cancer patients in the prone position is a feasible imaging technique for tumor staging before treatment to evaluate primary breast tumors, lymph nodes, lungs, or thoracic bones with reduced radiation doses.

Original languageEnglish
Pages (from-to)357-365
Number of pages9
JournalJournal of Breast Cancer
Volume13
Issue number4
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Prone Position
Multidetector Computed Tomography
Neoplasm Staging
Breast Neoplasms
Breast
Lung
Bone and Bones
Lymph
Tomography
Neoplasm Metastasis
Neoplasms
Neck
Thorax
Lymph Nodes
Radiation
Liver
Therapeutics

Keywords

  • Breast
  • Carcinoma
  • Multi-detector row computed tomography

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The clinical use of low-dose multidetector row computed tomography for breast cancer patients in the prone position. / Lee, Woo Jin; Seo, Bo Kyoung; Cho, Pyung Kon; Yie, Ann; Cho, Kyu Ran; Woo, Ok Hee; Cha, Sang Hoon; Son, Gil Soo; Lee, Guen Young.

In: Journal of Breast Cancer, Vol. 13, No. 4, 01.12.2010, p. 357-365.

Research output: Contribution to journalArticle

@article{d527005552a44b06a657036339889a53,
title = "The clinical use of low-dose multidetector row computed tomography for breast cancer patients in the prone position",
abstract = "Purpose: To investigate the clinical use of low-dose multidetector row computed tomography (MDCT) for staging of invasive breast cancers with patients in the prone position. Methods: Three hundred twenty-two patients with 334 pathologically-verified breast cancers had low-dose MDCT breast imaging in the prone position for tumor staging before treatment between May 2006 and June 2010. We designed an additional computed tomography table pad with a hole for prone positioning. Patients lay prone on the table pad and the breasts were positioned within the rectangular hole. We obtained dynamic breast imaging from the lower neck to the lung base with the following parameters: 120 kVp, 50 mAs, and 3-mm reconstruction intervals. We evaluated the extent of the primary tumor, lymph nodal status, and distant metastasis in lung or bone, then assessed tumor staging based on the TNM classification of breast cancer. The assessed staging compared to the pathologic results for diagnostic accuracy. Results: Among the 334 invasive breast cancers, the overall diagnostic accuracy of tumor staging was 88.3{\%} and the accuracy values of each tumor stage were 89.6{\%} in T1, 90.8{\%} in T2, 81.0{\%} in T3, and 89.3{\%} in T4. The overall diagnostic accuracy of lymph nodal staging was 86.3{\%} and the accuracy values in each nodal stage were 82.9{\%} in N0, 88.0{\%} in N1, 89.7{\%} in N2, and 93.3{\%} in N3. Based on breast computed tomography scans, we detected distant metastases in 30 cases (7 lungs, 10 bones, 7 lungs and bones, and 6 livers). Conclusion: Lowdose MDCT scanning for invasive breast cancer patients in the prone position is a feasible imaging technique for tumor staging before treatment to evaluate primary breast tumors, lymph nodes, lungs, or thoracic bones with reduced radiation doses.",
keywords = "Breast, Carcinoma, Multi-detector row computed tomography",
author = "Lee, {Woo Jin} and Seo, {Bo Kyoung} and Cho, {Pyung Kon} and Ann Yie and Cho, {Kyu Ran} and Woo, {Ok Hee} and Cha, {Sang Hoon} and Son, {Gil Soo} and Lee, {Guen Young}",
year = "2010",
month = "12",
day = "1",
doi = "10.4048/jbc.2010.13.4.357",
language = "English",
volume = "13",
pages = "357--365",
journal = "Journal of Breast Cancer",
issn = "1738-6756",
publisher = "Korean Breast Cancer Society",
number = "4",

}

TY - JOUR

T1 - The clinical use of low-dose multidetector row computed tomography for breast cancer patients in the prone position

AU - Lee, Woo Jin

AU - Seo, Bo Kyoung

AU - Cho, Pyung Kon

AU - Yie, Ann

AU - Cho, Kyu Ran

AU - Woo, Ok Hee

AU - Cha, Sang Hoon

AU - Son, Gil Soo

AU - Lee, Guen Young

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Purpose: To investigate the clinical use of low-dose multidetector row computed tomography (MDCT) for staging of invasive breast cancers with patients in the prone position. Methods: Three hundred twenty-two patients with 334 pathologically-verified breast cancers had low-dose MDCT breast imaging in the prone position for tumor staging before treatment between May 2006 and June 2010. We designed an additional computed tomography table pad with a hole for prone positioning. Patients lay prone on the table pad and the breasts were positioned within the rectangular hole. We obtained dynamic breast imaging from the lower neck to the lung base with the following parameters: 120 kVp, 50 mAs, and 3-mm reconstruction intervals. We evaluated the extent of the primary tumor, lymph nodal status, and distant metastasis in lung or bone, then assessed tumor staging based on the TNM classification of breast cancer. The assessed staging compared to the pathologic results for diagnostic accuracy. Results: Among the 334 invasive breast cancers, the overall diagnostic accuracy of tumor staging was 88.3% and the accuracy values of each tumor stage were 89.6% in T1, 90.8% in T2, 81.0% in T3, and 89.3% in T4. The overall diagnostic accuracy of lymph nodal staging was 86.3% and the accuracy values in each nodal stage were 82.9% in N0, 88.0% in N1, 89.7% in N2, and 93.3% in N3. Based on breast computed tomography scans, we detected distant metastases in 30 cases (7 lungs, 10 bones, 7 lungs and bones, and 6 livers). Conclusion: Lowdose MDCT scanning for invasive breast cancer patients in the prone position is a feasible imaging technique for tumor staging before treatment to evaluate primary breast tumors, lymph nodes, lungs, or thoracic bones with reduced radiation doses.

AB - Purpose: To investigate the clinical use of low-dose multidetector row computed tomography (MDCT) for staging of invasive breast cancers with patients in the prone position. Methods: Three hundred twenty-two patients with 334 pathologically-verified breast cancers had low-dose MDCT breast imaging in the prone position for tumor staging before treatment between May 2006 and June 2010. We designed an additional computed tomography table pad with a hole for prone positioning. Patients lay prone on the table pad and the breasts were positioned within the rectangular hole. We obtained dynamic breast imaging from the lower neck to the lung base with the following parameters: 120 kVp, 50 mAs, and 3-mm reconstruction intervals. We evaluated the extent of the primary tumor, lymph nodal status, and distant metastasis in lung or bone, then assessed tumor staging based on the TNM classification of breast cancer. The assessed staging compared to the pathologic results for diagnostic accuracy. Results: Among the 334 invasive breast cancers, the overall diagnostic accuracy of tumor staging was 88.3% and the accuracy values of each tumor stage were 89.6% in T1, 90.8% in T2, 81.0% in T3, and 89.3% in T4. The overall diagnostic accuracy of lymph nodal staging was 86.3% and the accuracy values in each nodal stage were 82.9% in N0, 88.0% in N1, 89.7% in N2, and 93.3% in N3. Based on breast computed tomography scans, we detected distant metastases in 30 cases (7 lungs, 10 bones, 7 lungs and bones, and 6 livers). Conclusion: Lowdose MDCT scanning for invasive breast cancer patients in the prone position is a feasible imaging technique for tumor staging before treatment to evaluate primary breast tumors, lymph nodes, lungs, or thoracic bones with reduced radiation doses.

KW - Breast

KW - Carcinoma

KW - Multi-detector row computed tomography

UR - http://www.scopus.com/inward/record.url?scp=79251497683&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79251497683&partnerID=8YFLogxK

U2 - 10.4048/jbc.2010.13.4.357

DO - 10.4048/jbc.2010.13.4.357

M3 - Article

VL - 13

SP - 357

EP - 365

JO - Journal of Breast Cancer

JF - Journal of Breast Cancer

SN - 1738-6756

IS - 4

ER -