The clinical usefulness of the SD bioline influenza antigen test® for detecting the 2009 influenza A (H1N1) virus

Won Suk Choi, Ji Yun Noh, Joong Yeon Huh, Sae Yoon Kee, Hye Won Jeong, Jacob Lee, Joon Young Song, Hee Jin Cheong, Woo Joo Kim

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Though the 2009 worldwide influenza A (H1N1) pandemic has been declared to have ended, the influenza virus is expected to continue to circulate from some years as a seasonal influenza. A rapid antigen test (RAT) can aid in rapid diagnosis and allow for early antiviral treatment. We evaluated the clinical usefulness of RAT using SD Bioline Influenza Antigen Test® kit to detect the influenza virus, considering various factors. From August 1, 2009 to October 10, 2009, a total of 938 patients who visited the outpatient clinic at Korea University Guro Hospital with influenza-like illnesses were enrolled in the study. Throat or nasopharyngeal swab specimens were obtained from each of the patients. Using these specimens, we evaluated the influenza detection rate by rapid antigen test based on the real-time reverse-transcriptase polymerase chain reaction (rRT-PCR) method. In comparison with rRT-PCR, the sensitivity and specificity of the R AT were 44.0% and 99.9%, respectively. The cyclic threshold values of RAT negative specimens were higher than RAT positive specimens (30.1±3.1 vs. 28.3±3.9, p=0.031). The sensitivity of the RAT kit was higher in patients who visited clinics within two days of symptom onset (60.4% vs. 11.1%, p=0.026). The results of this study show that the RAT cannot be recommended for general use in all patients with influenza-like illness because of its low sensitivity. The RAT may be used, only in the settings with limited diagnostic resources, for patients who visit a clinic within two days of symptom onset.

    Original languageEnglish
    Pages (from-to)683-685
    Number of pages3
    JournalYonsei medical journal
    Volume52
    Issue number4
    DOIs
    Publication statusPublished - 2011 Jul

    Keywords

    • Diagnosis
    • Influenza
    • Sensitivity
    • Specificity

    ASJC Scopus subject areas

    • Medicine(all)

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