The current status of ulcerative colitis-associated colorectal cancer in Korea

a KASID study

Dong Kyung Chang, Young Ho Kim, Jeong Sik Byeon, Suk Kyun Yang, Yong Woo Chung, Dong Soo Han, Sang Gyun Kim, Tae Il Kim, Won Ho Kim, Yoon Tae Jeen, Chang Soo Eun, Hwang Choi, Kyu Yong Choi, In Sung Song

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

BACKGROUND/AIMS: The number of patients with ulcerative colitis has steadily increased since the mid-1980s. As the risk of colon cancer increases with duration and extents, colitic cancers are expected to increase in number in Korea. We surveyed the current status of colitic cancers and provided the perspectives in Korea. METHODS: Korean Association for the Study of Intestinal Diseases (KASID) collected and descriptively analyzed a total of eleven cases of colitic cancers occurred between 1993 and 2003. RESULTS: The mean age at the diagnosis of colitic cancer was 49.3 years, and the mean duration of ulcerative colitis was 12.5 years. Of the diagnosed cases, 91% was associated with pancolitis, 28% had right colon cancers and 18.2% had multiple tumors. Colitic cancers diagnosed at Dukes' stage D were 36.3%. Stages at diagnosis were lower in patients with good compliance. Up to 2003, cumulative incidence ratio of colitic cancer to ulcerative colitis was estimated to be 0.5%, which was much less than the overall prevalence of 3.7% in the Western countries. This incidence was also less than the expected cumulative incidence ratio of 0.9%, which was estimated by adopting the average results of meta-analysis in the Western world. CONCLUSIONS: As the incidence of ulcerative colitis has not reached a plateau, and as the diagnosis of colitic caners are delayed in Korea, the cumulative incidence of colitic cancers might have appeared to be low. Geographic and racial factors, and the effect of preventive measures might have contributed to the lower incidence which remains to be proven. Since colitic cancers are expected to increase steeply in the near future in Korea, the importance of surveillance and prevention cannot be over-emphasized.

Original languageEnglish
Pages (from-to)276-282
Number of pages7
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume46
Issue number4
Publication statusPublished - 2005 Jan 1
Externally publishedYes

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Intestinal Diseases
Korea
Ulcerative Colitis
Colorectal Neoplasms
Neoplasms
Incidence
Colonic Neoplasms
Western World
Geography
Meta-Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chang, D. K., Kim, Y. H., Byeon, J. S., Yang, S. K., Chung, Y. W., Han, D. S., ... Song, I. S. (2005). The current status of ulcerative colitis-associated colorectal cancer in Korea: a KASID study. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 46(4), 276-282.

The current status of ulcerative colitis-associated colorectal cancer in Korea : a KASID study. / Chang, Dong Kyung; Kim, Young Ho; Byeon, Jeong Sik; Yang, Suk Kyun; Chung, Yong Woo; Han, Dong Soo; Kim, Sang Gyun; Kim, Tae Il; Kim, Won Ho; Jeen, Yoon Tae; Eun, Chang Soo; Choi, Hwang; Choi, Kyu Yong; Song, In Sung.

In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, Vol. 46, No. 4, 01.01.2005, p. 276-282.

Research output: Contribution to journalArticle

Chang, DK, Kim, YH, Byeon, JS, Yang, SK, Chung, YW, Han, DS, Kim, SG, Kim, TI, Kim, WH, Jeen, YT, Eun, CS, Choi, H, Choi, KY & Song, IS 2005, 'The current status of ulcerative colitis-associated colorectal cancer in Korea: a KASID study', The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, vol. 46, no. 4, pp. 276-282.
Chang, Dong Kyung ; Kim, Young Ho ; Byeon, Jeong Sik ; Yang, Suk Kyun ; Chung, Yong Woo ; Han, Dong Soo ; Kim, Sang Gyun ; Kim, Tae Il ; Kim, Won Ho ; Jeen, Yoon Tae ; Eun, Chang Soo ; Choi, Hwang ; Choi, Kyu Yong ; Song, In Sung. / The current status of ulcerative colitis-associated colorectal cancer in Korea : a KASID study. In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. 2005 ; Vol. 46, No. 4. pp. 276-282.
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title = "The current status of ulcerative colitis-associated colorectal cancer in Korea: a KASID study",
abstract = "BACKGROUND/AIMS: The number of patients with ulcerative colitis has steadily increased since the mid-1980s. As the risk of colon cancer increases with duration and extents, colitic cancers are expected to increase in number in Korea. We surveyed the current status of colitic cancers and provided the perspectives in Korea. METHODS: Korean Association for the Study of Intestinal Diseases (KASID) collected and descriptively analyzed a total of eleven cases of colitic cancers occurred between 1993 and 2003. RESULTS: The mean age at the diagnosis of colitic cancer was 49.3 years, and the mean duration of ulcerative colitis was 12.5 years. Of the diagnosed cases, 91{\%} was associated with pancolitis, 28{\%} had right colon cancers and 18.2{\%} had multiple tumors. Colitic cancers diagnosed at Dukes' stage D were 36.3{\%}. Stages at diagnosis were lower in patients with good compliance. Up to 2003, cumulative incidence ratio of colitic cancer to ulcerative colitis was estimated to be 0.5{\%}, which was much less than the overall prevalence of 3.7{\%} in the Western countries. This incidence was also less than the expected cumulative incidence ratio of 0.9{\%}, which was estimated by adopting the average results of meta-analysis in the Western world. CONCLUSIONS: As the incidence of ulcerative colitis has not reached a plateau, and as the diagnosis of colitic caners are delayed in Korea, the cumulative incidence of colitic cancers might have appeared to be low. Geographic and racial factors, and the effect of preventive measures might have contributed to the lower incidence which remains to be proven. Since colitic cancers are expected to increase steeply in the near future in Korea, the importance of surveillance and prevention cannot be over-emphasized.",
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T1 - The current status of ulcerative colitis-associated colorectal cancer in Korea

T2 - a KASID study

AU - Chang, Dong Kyung

AU - Kim, Young Ho

AU - Byeon, Jeong Sik

AU - Yang, Suk Kyun

AU - Chung, Yong Woo

AU - Han, Dong Soo

AU - Kim, Sang Gyun

AU - Kim, Tae Il

AU - Kim, Won Ho

AU - Jeen, Yoon Tae

AU - Eun, Chang Soo

AU - Choi, Hwang

AU - Choi, Kyu Yong

AU - Song, In Sung

PY - 2005/1/1

Y1 - 2005/1/1

N2 - BACKGROUND/AIMS: The number of patients with ulcerative colitis has steadily increased since the mid-1980s. As the risk of colon cancer increases with duration and extents, colitic cancers are expected to increase in number in Korea. We surveyed the current status of colitic cancers and provided the perspectives in Korea. METHODS: Korean Association for the Study of Intestinal Diseases (KASID) collected and descriptively analyzed a total of eleven cases of colitic cancers occurred between 1993 and 2003. RESULTS: The mean age at the diagnosis of colitic cancer was 49.3 years, and the mean duration of ulcerative colitis was 12.5 years. Of the diagnosed cases, 91% was associated with pancolitis, 28% had right colon cancers and 18.2% had multiple tumors. Colitic cancers diagnosed at Dukes' stage D were 36.3%. Stages at diagnosis were lower in patients with good compliance. Up to 2003, cumulative incidence ratio of colitic cancer to ulcerative colitis was estimated to be 0.5%, which was much less than the overall prevalence of 3.7% in the Western countries. This incidence was also less than the expected cumulative incidence ratio of 0.9%, which was estimated by adopting the average results of meta-analysis in the Western world. CONCLUSIONS: As the incidence of ulcerative colitis has not reached a plateau, and as the diagnosis of colitic caners are delayed in Korea, the cumulative incidence of colitic cancers might have appeared to be low. Geographic and racial factors, and the effect of preventive measures might have contributed to the lower incidence which remains to be proven. Since colitic cancers are expected to increase steeply in the near future in Korea, the importance of surveillance and prevention cannot be over-emphasized.

AB - BACKGROUND/AIMS: The number of patients with ulcerative colitis has steadily increased since the mid-1980s. As the risk of colon cancer increases with duration and extents, colitic cancers are expected to increase in number in Korea. We surveyed the current status of colitic cancers and provided the perspectives in Korea. METHODS: Korean Association for the Study of Intestinal Diseases (KASID) collected and descriptively analyzed a total of eleven cases of colitic cancers occurred between 1993 and 2003. RESULTS: The mean age at the diagnosis of colitic cancer was 49.3 years, and the mean duration of ulcerative colitis was 12.5 years. Of the diagnosed cases, 91% was associated with pancolitis, 28% had right colon cancers and 18.2% had multiple tumors. Colitic cancers diagnosed at Dukes' stage D were 36.3%. Stages at diagnosis were lower in patients with good compliance. Up to 2003, cumulative incidence ratio of colitic cancer to ulcerative colitis was estimated to be 0.5%, which was much less than the overall prevalence of 3.7% in the Western countries. This incidence was also less than the expected cumulative incidence ratio of 0.9%, which was estimated by adopting the average results of meta-analysis in the Western world. CONCLUSIONS: As the incidence of ulcerative colitis has not reached a plateau, and as the diagnosis of colitic caners are delayed in Korea, the cumulative incidence of colitic cancers might have appeared to be low. Geographic and racial factors, and the effect of preventive measures might have contributed to the lower incidence which remains to be proven. Since colitic cancers are expected to increase steeply in the near future in Korea, the importance of surveillance and prevention cannot be over-emphasized.

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VL - 46

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EP - 282

JO - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

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SN - 1598-9992

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