The detection of Epstein-Barr virus in the lesions of salivary glands

K. I. Kim Kwang Il, Young Sik Kim, Han Kyeom Kim, Yang Seok Chae, Bom Woo Yoem, Insun Kim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) is known in association with lymphoid and epithelial lesions. Because the salivary gland is an organ close to the oropharynx, it has a higher incidence of EBV infection and is a possible route of EBV infection. Formalin-fixed, paraffin embedded tissue sections of 87 cases of salivary gland diseases were used for the study of EBV with PCR, in situ PCR for EBNA-1 (EBV nuclear antigen-1), and immunohistochemistry for LMP-1 (latent membrane protein-1). EBV was detected in 12 cases (13.8%): 7 of nonspecific chronic sialadenitis (21.2%), 4 of Warthin's tumors (30.8%), and one lymphoepithelial carcinoma. EBNA-1 was negative in all the other lesions, EBV DNA was detected in the nucleus of epithelial cells and the surrounding lymphocytes. LMP-1 positivity was found in the cytoplasm of epithelial cells. The results of the present study showed that EBV is implicated in some of the inflammatory and neoplastic lesions of the salivary gland in which the lymphocytes are abundant. However, the pathogenesis and mechanism of immortalization and tumorigenesis of the epithelial cells in the salivary glands remain to be determined.

Original languageEnglish
Pages (from-to)407-412
Number of pages6
JournalPathology Research and Practice
Volume195
Issue number6
Publication statusPublished - 1999 Jul 6

Fingerprint

Salivary Glands
Human Herpesvirus 4
Epstein-Barr Virus Nuclear Antigens
Epstein-Barr Virus Infections
Epithelial Cells
Membrane Proteins
Salivary Gland Diseases
Adenolymphoma
Lymphocytes
Sialadenitis
Polymerase Chain Reaction
Oropharynx
Paraffin
Formaldehyde
Carcinogenesis
Cytoplasm
Immunohistochemistry
Carcinoma
DNA
Incidence

Keywords

  • EBV
  • In situ PCR
  • LMP-1
  • Salivary gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The detection of Epstein-Barr virus in the lesions of salivary glands. / Kim Kwang Il, K. I.; Kim, Young Sik; Kim, Han Kyeom; Chae, Yang Seok; Yoem, Bom Woo; Kim, Insun.

In: Pathology Research and Practice, Vol. 195, No. 6, 06.07.1999, p. 407-412.

Research output: Contribution to journalArticle

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