The differential relationship between fat mass and bone mineral density by gender and menopausal status

Hye-Jin Yoo, Man Sik Park, Sae Jeong Yang, Tae Nyun Kim, Kang Il Lim, Hyun Joo Kang, Wook Song, Sei-Hyun Baik, Dong Seop Choi, Kyung Mook Choi

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Osteoporosis and obesity are important public health problems in an aging society. We investigated the differential impacts of fat on bone mineral density (BMD) according to gender and menopausal status. We analyzed the baseline data of an ongoing observational cohort study, including a total of 502 healthy subjects 20-88 years of age (144 men, 159 premenopausal women, 199 postmenopausal women). Body composition and fat mass were measured using computed tomography and dual energy X-ray absorptiometry (DXA). BMD was measured at lumbar spines using DXA. In men and postmenopausal women, there was no significant correlation between fat and bone parameters after adjusting for age and body weight. However, in premenopausal women, BMD had significant negative correlations with waist circumference, total fat area, subcutaneous fat area, appendicular fat mass and percentage fat mass after adjusting for age and body weight. Furthermore, only in premenopausal women, the subjects with the highest quartile of percentage fat mass had the lowest BMD even after adjusting for confounding factors including age, body weight, physical activity, alcohol use and smoking history. Multiple linear regression analysis showed that percentage fat mass was a significant negative decisive factor for BMD in premenopausal women. Our study showed the differential relationship between fat mass and BMD according to gender and menopausal status. Only in premenopausal women did fat mass have a significant negative effect on bone mass. This result suggests the importance of reducing fat mass in order to achieve peak bone mass in young adult women.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalJournal of Bone and Mineral Metabolism
Volume30
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Bone Density
Fats
Body Weight
Photon Absorptiometry
Bone and Bones
Subcutaneous Fat
Age Factors
Waist Circumference
Body Composition
Osteoporosis
Observational Studies
Adipose Tissue
Young Adult
Linear Models
Healthy Volunteers
Spine
Cohort Studies
Public Health
Obesity
Smoking

Keywords

  • Fat mass
  • Menopause
  • Osteoporosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

The differential relationship between fat mass and bone mineral density by gender and menopausal status. / Yoo, Hye-Jin; Park, Man Sik; Yang, Sae Jeong; Kim, Tae Nyun; Lim, Kang Il; Kang, Hyun Joo; Song, Wook; Baik, Sei-Hyun; Choi, Dong Seop; Choi, Kyung Mook.

In: Journal of Bone and Mineral Metabolism, Vol. 30, No. 1, 01.01.2012, p. 47-53.

Research output: Contribution to journalArticle

Yoo, Hye-Jin ; Park, Man Sik ; Yang, Sae Jeong ; Kim, Tae Nyun ; Lim, Kang Il ; Kang, Hyun Joo ; Song, Wook ; Baik, Sei-Hyun ; Choi, Dong Seop ; Choi, Kyung Mook. / The differential relationship between fat mass and bone mineral density by gender and menopausal status. In: Journal of Bone and Mineral Metabolism. 2012 ; Vol. 30, No. 1. pp. 47-53.
@article{eb9107085d294afba154b9df2a5b5b89,
title = "The differential relationship between fat mass and bone mineral density by gender and menopausal status",
abstract = "Osteoporosis and obesity are important public health problems in an aging society. We investigated the differential impacts of fat on bone mineral density (BMD) according to gender and menopausal status. We analyzed the baseline data of an ongoing observational cohort study, including a total of 502 healthy subjects 20-88 years of age (144 men, 159 premenopausal women, 199 postmenopausal women). Body composition and fat mass were measured using computed tomography and dual energy X-ray absorptiometry (DXA). BMD was measured at lumbar spines using DXA. In men and postmenopausal women, there was no significant correlation between fat and bone parameters after adjusting for age and body weight. However, in premenopausal women, BMD had significant negative correlations with waist circumference, total fat area, subcutaneous fat area, appendicular fat mass and percentage fat mass after adjusting for age and body weight. Furthermore, only in premenopausal women, the subjects with the highest quartile of percentage fat mass had the lowest BMD even after adjusting for confounding factors including age, body weight, physical activity, alcohol use and smoking history. Multiple linear regression analysis showed that percentage fat mass was a significant negative decisive factor for BMD in premenopausal women. Our study showed the differential relationship between fat mass and BMD according to gender and menopausal status. Only in premenopausal women did fat mass have a significant negative effect on bone mass. This result suggests the importance of reducing fat mass in order to achieve peak bone mass in young adult women.",
keywords = "Fat mass, Menopause, Osteoporosis",
author = "Hye-Jin Yoo and Park, {Man Sik} and Yang, {Sae Jeong} and Kim, {Tae Nyun} and Lim, {Kang Il} and Kang, {Hyun Joo} and Wook Song and Sei-Hyun Baik and Choi, {Dong Seop} and Choi, {Kyung Mook}",
year = "2012",
month = "1",
day = "1",
doi = "10.1007/s00774-011-0283-7",
language = "English",
volume = "30",
pages = "47--53",
journal = "Journal of Bone and Mineral Metabolism",
issn = "0914-8779",
publisher = "Springer Japan",
number = "1",

}

TY - JOUR

T1 - The differential relationship between fat mass and bone mineral density by gender and menopausal status

AU - Yoo, Hye-Jin

AU - Park, Man Sik

AU - Yang, Sae Jeong

AU - Kim, Tae Nyun

AU - Lim, Kang Il

AU - Kang, Hyun Joo

AU - Song, Wook

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Choi, Kyung Mook

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Osteoporosis and obesity are important public health problems in an aging society. We investigated the differential impacts of fat on bone mineral density (BMD) according to gender and menopausal status. We analyzed the baseline data of an ongoing observational cohort study, including a total of 502 healthy subjects 20-88 years of age (144 men, 159 premenopausal women, 199 postmenopausal women). Body composition and fat mass were measured using computed tomography and dual energy X-ray absorptiometry (DXA). BMD was measured at lumbar spines using DXA. In men and postmenopausal women, there was no significant correlation between fat and bone parameters after adjusting for age and body weight. However, in premenopausal women, BMD had significant negative correlations with waist circumference, total fat area, subcutaneous fat area, appendicular fat mass and percentage fat mass after adjusting for age and body weight. Furthermore, only in premenopausal women, the subjects with the highest quartile of percentage fat mass had the lowest BMD even after adjusting for confounding factors including age, body weight, physical activity, alcohol use and smoking history. Multiple linear regression analysis showed that percentage fat mass was a significant negative decisive factor for BMD in premenopausal women. Our study showed the differential relationship between fat mass and BMD according to gender and menopausal status. Only in premenopausal women did fat mass have a significant negative effect on bone mass. This result suggests the importance of reducing fat mass in order to achieve peak bone mass in young adult women.

AB - Osteoporosis and obesity are important public health problems in an aging society. We investigated the differential impacts of fat on bone mineral density (BMD) according to gender and menopausal status. We analyzed the baseline data of an ongoing observational cohort study, including a total of 502 healthy subjects 20-88 years of age (144 men, 159 premenopausal women, 199 postmenopausal women). Body composition and fat mass were measured using computed tomography and dual energy X-ray absorptiometry (DXA). BMD was measured at lumbar spines using DXA. In men and postmenopausal women, there was no significant correlation between fat and bone parameters after adjusting for age and body weight. However, in premenopausal women, BMD had significant negative correlations with waist circumference, total fat area, subcutaneous fat area, appendicular fat mass and percentage fat mass after adjusting for age and body weight. Furthermore, only in premenopausal women, the subjects with the highest quartile of percentage fat mass had the lowest BMD even after adjusting for confounding factors including age, body weight, physical activity, alcohol use and smoking history. Multiple linear regression analysis showed that percentage fat mass was a significant negative decisive factor for BMD in premenopausal women. Our study showed the differential relationship between fat mass and BMD according to gender and menopausal status. Only in premenopausal women did fat mass have a significant negative effect on bone mass. This result suggests the importance of reducing fat mass in order to achieve peak bone mass in young adult women.

KW - Fat mass

KW - Menopause

KW - Osteoporosis

UR - http://www.scopus.com/inward/record.url?scp=84863337599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863337599&partnerID=8YFLogxK

U2 - 10.1007/s00774-011-0283-7

DO - 10.1007/s00774-011-0283-7

M3 - Article

VL - 30

SP - 47

EP - 53

JO - Journal of Bone and Mineral Metabolism

JF - Journal of Bone and Mineral Metabolism

SN - 0914-8779

IS - 1

ER -