The discovery of druggable anti-aging agents

Gulperi Yalcin, Cheol Koo Lee

Research output: Contribution to journalReview articlepeer-review

Abstract

Caloric restriction (CR) has been shown to extend the lifespan of many species. Research to identify compounds that imitate the results of CR has shown extensions of both lifespan and healthspan via different mechanisms. For example, mechanistic target of rapamycin (mTOR) inhibitors such as rapamycin affect nutrient-sensing pathways; phenols and flavonoids show antioxidant characteristics; aspirin has anti-inflammatory effects, while spermidine induces autophagy. Herein, we summarize research progress and proposed mechanisms for the most well-known compounds showing lifespan-extending potential for anti-aging characteristics.

Original languageEnglish
Pages (from-to)232-242
Number of pages11
JournalAnnals of Geriatric Medicine and Research
Volume24
Issue number4
DOIs
Publication statusPublished - 2020 Dec

Keywords

  • Anti-aging
  • Caloric restriction mimetics
  • Lifespan extension

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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