The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis

Nicholas Asiimwe, Mohammad Faysal Al Mazid, Yong Taek Jeong, Juyong Lee, Jun-Seok Lee

Research output: Contribution to journalArticlepeer-review

Abstract

The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In this study, we investigated penta-peptide ligands for FGE activity inhibition and discovered two hit peptides. In addition, the lead peptides also showed potential antibacterial effects in a Mycobacterium tuberculosis model.

Original languageEnglish
Pages (from-to)18884-18888
Number of pages5
JournalRSC Advances
Volume12
Issue number29
DOIs
Publication statusPublished - 2022 Jun 29

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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