The distribution of neuron-specific gene family member 1 in brain and germ cells: Implications for the regulation of germ-line development by brain

Deivendran Rengaraj, Bo Ram Lee, Kyung Je Park, Sang In Lee, Kyung Soo Kang, Jin Won Choi, Seok Jin Kang, Gwonhwa Song, Jae Yong Han

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Vesicular acidification at early endosomes dissociates endocytosed receptor-ligand complexes. The ligands, receptors, or both are then directed to late endosomes for degradation or recycled back to the plasma membrane. Of neuron-specific gene (NSG) family members, early endosomal protein neuron-specific gene family member 1 (NSG1) is the most important in receptor recycling. In this study, we characterized chicken NSG1 (cNSG1). We found several functional sites related to endocytotic machinery in cNSG1 that were highly conserved with most other vertebrate NSG1 proteins. We examined the tissue and duration specificity and the temporal and spatial patterns of cNSG1 expression. cNSG1 expression was preferentially located in all regions of the brain, neuroendocrine glands, and spinal cord. Unexpectedly, cNSG1 expression was strongly detected during male and female germ-line development. Expression of NSG1 in two apparently unrelated cell types such as neurons and germ cells suggests NSG1 roles in neurons and germ-cells chemotaxis and endocytotic machinery.

Original languageEnglish
Pages (from-to)850-861
Number of pages12
JournalDevelopmental Dynamics
Volume240
Issue number4
DOIs
Publication statusPublished - 2011 Apr 1
Externally publishedYes

Fingerprint

Germ Cells
Neurons
Brain
Chickens
Genes
Endosomes
Ligands
Organ Specificity
Chemotaxis
Endocytosis
Vertebrates
Spinal Cord
Proteins
Cell Membrane

Keywords

  • Brain-derived factors
  • Chickens
  • Germ-line development
  • Neuron-specific gene family member 1 (NSG1)

ASJC Scopus subject areas

  • Developmental Biology

Cite this

The distribution of neuron-specific gene family member 1 in brain and germ cells : Implications for the regulation of germ-line development by brain. / Rengaraj, Deivendran; Lee, Bo Ram; Park, Kyung Je; Lee, Sang In; Kang, Kyung Soo; Choi, Jin Won; Kang, Seok Jin; Song, Gwonhwa; Han, Jae Yong.

In: Developmental Dynamics, Vol. 240, No. 4, 01.04.2011, p. 850-861.

Research output: Contribution to journalArticle

Rengaraj, Deivendran ; Lee, Bo Ram ; Park, Kyung Je ; Lee, Sang In ; Kang, Kyung Soo ; Choi, Jin Won ; Kang, Seok Jin ; Song, Gwonhwa ; Han, Jae Yong. / The distribution of neuron-specific gene family member 1 in brain and germ cells : Implications for the regulation of germ-line development by brain. In: Developmental Dynamics. 2011 ; Vol. 240, No. 4. pp. 850-861.
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