The dual binding site of angiogenin and its inhibition mechanism: The crystal structure of the rat angiogenin-heparin complex

Kwon Joo Yeo, Eunha Hwang, Kyong Mi Min, Jun Goo Jee, Chung Kyung Lee, Kwang Yeon Hwang, Young Ho Jeon, Soo Ik Chang, Hae Kap Cheong

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin, suggesting that cell adhesion to angiogenin is facilitated by its interaction with substrates on the cell surface and can be inhibited by heparin.

Original languageEnglish
Pages (from-to)12966-12969
Number of pages4
JournalChemical Communications
Volume50
Issue number85
DOIs
Publication statusPublished - 2014 Sep 30

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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