The effect of 1 μg/kg dexmedetomidine combined with high-volume/low-concentration caudal ropivacaine in children undergoing ambulatory orchiopexy

Jang-Eun Cho, Ji Young Kim, Sang Jae Park, Hae Keum Kil

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

When local anesthetics are used, the administration of dexmedetomidine (DEX) can prolong analgesic duration. However, the effect of caudal DEX on high volume/low concentration (HVLC) local anesthetics has not been studied. We investigated the analgesic effect of DEX added to a HVLC of ropivacaine for caudal block in children. Eighty children (the American Society of Anesthesiologists (ASA) status I; age, 1-6 years) undergoing ambulatory orchiopexy were enrolled in the study. Children were randomly assigned to undergo a caudal block with 1.5 mL/kg of 0.15% ropivacaine and either 1 μg/kg of DEX (DEX group, n=40) or the same amount of saline (Control group, n=40) under general anesthesia. The results showed that the time to first analgesic request was significantly longer in the DEX group than in the control group. The sevoflurane requirement for anesthesia and frequency of emergence agitation (EA) were also significantly lower in the DEX group. There was no difference in adverse events between the two groups. In conclusion, a dose of 1 μg/kg of caudal DEX prolonged the first analgesic request time, although the immediate postoperative pain scores were comparable in both groups. Furthermore, caudal DEX significantly reduced the sevoflurane requirement and the frequency of EA.

Original languageEnglish
Pages (from-to)1020-1025
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume38
Issue number7
Publication statusPublished - 2015 Jul 1

Fingerprint

Orchiopexy
Dexmedetomidine
Analgesics
Local Anesthetics
ropivacaine
Control Groups
Postoperative Pain
General Anesthesia
Anesthesia

Keywords

  • Caudal block
  • Child
  • Dexmedetomidine
  • Orchiopexy

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

The effect of 1 μg/kg dexmedetomidine combined with high-volume/low-concentration caudal ropivacaine in children undergoing ambulatory orchiopexy. / Cho, Jang-Eun; Kim, Ji Young; Park, Sang Jae; Kil, Hae Keum.

In: Biological and Pharmaceutical Bulletin, Vol. 38, No. 7, 01.07.2015, p. 1020-1025.

Research output: Contribution to journalArticle

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