The effect of alpha lipoic acid (Thioctacid HR®) on endothelial function in diabetic and hypertensive patients

Sang Rok Lee, Myung Ho Jeong, Sang Yeob Lim, Seo Na Hong, Kye Hun Kim, Il Suk Sohn, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Weon Kim, Young Keun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background and Objectives: α-Lipoic acid (ALA) is known to improve endothelial function in patients with diabetes. However, the effect of ALA on endothelial function in hypertensive patients is unknown. The aim of this study was to investigate whether ALA improves endothelial function in diabetic and hypertensive patients. Subjects and Methods: This study included 40 patients who were treated with ALA (Group I: 20 diabetic patients, 54.9 ± 10.2 years, Group II: 20 hypertensive patients, 56.5 ± 9.0 years). ALA was administered in 600 mg/day doses during the first four weeks, and 1,200 tng/day doses during the second four weeks. Clinical characteristics and endothelial function were assessed at baseline, 4 weeks and 8 weeks after ALA administration. Evaluation of patients included: assessment of the brachial artery for flow mediated vasodilation (FMD) and the inflammatory marker (high sensitive CRP: hsCRP). Results: Clinical characteristics (body mass index, total cholesterol/HDL-cholesterol and hsCRP) were unchanged in each group. However, FMD was significantly improved at 8 weeks after ALA therapy in both groups. Group I-baseline: 4 weeks: 8 weeks=4.1 ± 3.3:6.5 ± 2.2:8.0 ± 2.7, Group II-baseline: 4 weeks: 8 weeks=5.5 ± 3.7:7.4 ± 3.3:9.3 ± 2.7, p<0.05. The level of fibrinogen was observed to have an inverse correlation with FMD at 8 weeks after ALA therapy in Group I (p<0.05). Conclusion: ALA improves endothelial function in both diabetic and hypertensive patients.

Original languageEnglish
Pages (from-to)559-564
Number of pages6
JournalKorean Circulation Journal
Volume36
Issue number8
Publication statusPublished - 2006 Aug 1
Externally publishedYes

Fingerprint

Thioctic Acid
Vasodilation
Brachial Artery
Group Psychotherapy
Fibrinogen
HDL Cholesterol
Body Mass Index
Cholesterol

Keywords

  • Alpha lipoic acid
  • Hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Lee, S. R., Jeong, M. H., Lim, S. Y., Hong, S. N., Kim, K. H., Sohn, I. S., ... Kang, J. C. (2006). The effect of alpha lipoic acid (Thioctacid HR®) on endothelial function in diabetic and hypertensive patients. Korean Circulation Journal, 36(8), 559-564.

The effect of alpha lipoic acid (Thioctacid HR®) on endothelial function in diabetic and hypertensive patients. / Lee, Sang Rok; Jeong, Myung Ho; Lim, Sang Yeob; Hong, Seo Na; Kim, Kye Hun; Sohn, Il Suk; Hong, Young Joon; Park, Hyung Wook; Kim, Ju Han; Kim, Weon; Ahn, Young Keun; Cho, Jeong Gwan; Park, Jong Chun; Kang, Jung Chaee.

In: Korean Circulation Journal, Vol. 36, No. 8, 01.08.2006, p. 559-564.

Research output: Contribution to journalArticle

Lee, SR, Jeong, MH, Lim, SY, Hong, SN, Kim, KH, Sohn, IS, Hong, YJ, Park, HW, Kim, JH, Kim, W, Ahn, YK, Cho, JG, Park, JC & Kang, JC 2006, 'The effect of alpha lipoic acid (Thioctacid HR®) on endothelial function in diabetic and hypertensive patients', Korean Circulation Journal, vol. 36, no. 8, pp. 559-564.
Lee, Sang Rok ; Jeong, Myung Ho ; Lim, Sang Yeob ; Hong, Seo Na ; Kim, Kye Hun ; Sohn, Il Suk ; Hong, Young Joon ; Park, Hyung Wook ; Kim, Ju Han ; Kim, Weon ; Ahn, Young Keun ; Cho, Jeong Gwan ; Park, Jong Chun ; Kang, Jung Chaee. / The effect of alpha lipoic acid (Thioctacid HR®) on endothelial function in diabetic and hypertensive patients. In: Korean Circulation Journal. 2006 ; Vol. 36, No. 8. pp. 559-564.
@article{db160507fe234da9abbd0bf144754b77,
title = "The effect of alpha lipoic acid (Thioctacid HR{\circledR}) on endothelial function in diabetic and hypertensive patients",
abstract = "Background and Objectives: α-Lipoic acid (ALA) is known to improve endothelial function in patients with diabetes. However, the effect of ALA on endothelial function in hypertensive patients is unknown. The aim of this study was to investigate whether ALA improves endothelial function in diabetic and hypertensive patients. Subjects and Methods: This study included 40 patients who were treated with ALA (Group I: 20 diabetic patients, 54.9 ± 10.2 years, Group II: 20 hypertensive patients, 56.5 ± 9.0 years). ALA was administered in 600 mg/day doses during the first four weeks, and 1,200 tng/day doses during the second four weeks. Clinical characteristics and endothelial function were assessed at baseline, 4 weeks and 8 weeks after ALA administration. Evaluation of patients included: assessment of the brachial artery for flow mediated vasodilation (FMD) and the inflammatory marker (high sensitive CRP: hsCRP). Results: Clinical characteristics (body mass index, total cholesterol/HDL-cholesterol and hsCRP) were unchanged in each group. However, FMD was significantly improved at 8 weeks after ALA therapy in both groups. Group I-baseline: 4 weeks: 8 weeks=4.1 ± 3.3:6.5 ± 2.2:8.0 ± 2.7, Group II-baseline: 4 weeks: 8 weeks=5.5 ± 3.7:7.4 ± 3.3:9.3 ± 2.7, p<0.05. The level of fibrinogen was observed to have an inverse correlation with FMD at 8 weeks after ALA therapy in Group I (p<0.05). Conclusion: ALA improves endothelial function in both diabetic and hypertensive patients.",
keywords = "Alpha lipoic acid, Hypertension",
author = "Lee, {Sang Rok} and Jeong, {Myung Ho} and Lim, {Sang Yeob} and Hong, {Seo Na} and Kim, {Kye Hun} and Sohn, {Il Suk} and Hong, {Young Joon} and Park, {Hyung Wook} and Kim, {Ju Han} and Weon Kim and Ahn, {Young Keun} and Cho, {Jeong Gwan} and Park, {Jong Chun} and Kang, {Jung Chaee}",
year = "2006",
month = "8",
day = "1",
language = "English",
volume = "36",
pages = "559--564",
journal = "Korean Circulation Journal",
issn = "1738-5520",
publisher = "Korean Society of Circulation",
number = "8",

}

TY - JOUR

T1 - The effect of alpha lipoic acid (Thioctacid HR®) on endothelial function in diabetic and hypertensive patients

AU - Lee, Sang Rok

AU - Jeong, Myung Ho

AU - Lim, Sang Yeob

AU - Hong, Seo Na

AU - Kim, Kye Hun

AU - Sohn, Il Suk

AU - Hong, Young Joon

AU - Park, Hyung Wook

AU - Kim, Ju Han

AU - Kim, Weon

AU - Ahn, Young Keun

AU - Cho, Jeong Gwan

AU - Park, Jong Chun

AU - Kang, Jung Chaee

PY - 2006/8/1

Y1 - 2006/8/1

N2 - Background and Objectives: α-Lipoic acid (ALA) is known to improve endothelial function in patients with diabetes. However, the effect of ALA on endothelial function in hypertensive patients is unknown. The aim of this study was to investigate whether ALA improves endothelial function in diabetic and hypertensive patients. Subjects and Methods: This study included 40 patients who were treated with ALA (Group I: 20 diabetic patients, 54.9 ± 10.2 years, Group II: 20 hypertensive patients, 56.5 ± 9.0 years). ALA was administered in 600 mg/day doses during the first four weeks, and 1,200 tng/day doses during the second four weeks. Clinical characteristics and endothelial function were assessed at baseline, 4 weeks and 8 weeks after ALA administration. Evaluation of patients included: assessment of the brachial artery for flow mediated vasodilation (FMD) and the inflammatory marker (high sensitive CRP: hsCRP). Results: Clinical characteristics (body mass index, total cholesterol/HDL-cholesterol and hsCRP) were unchanged in each group. However, FMD was significantly improved at 8 weeks after ALA therapy in both groups. Group I-baseline: 4 weeks: 8 weeks=4.1 ± 3.3:6.5 ± 2.2:8.0 ± 2.7, Group II-baseline: 4 weeks: 8 weeks=5.5 ± 3.7:7.4 ± 3.3:9.3 ± 2.7, p<0.05. The level of fibrinogen was observed to have an inverse correlation with FMD at 8 weeks after ALA therapy in Group I (p<0.05). Conclusion: ALA improves endothelial function in both diabetic and hypertensive patients.

AB - Background and Objectives: α-Lipoic acid (ALA) is known to improve endothelial function in patients with diabetes. However, the effect of ALA on endothelial function in hypertensive patients is unknown. The aim of this study was to investigate whether ALA improves endothelial function in diabetic and hypertensive patients. Subjects and Methods: This study included 40 patients who were treated with ALA (Group I: 20 diabetic patients, 54.9 ± 10.2 years, Group II: 20 hypertensive patients, 56.5 ± 9.0 years). ALA was administered in 600 mg/day doses during the first four weeks, and 1,200 tng/day doses during the second four weeks. Clinical characteristics and endothelial function were assessed at baseline, 4 weeks and 8 weeks after ALA administration. Evaluation of patients included: assessment of the brachial artery for flow mediated vasodilation (FMD) and the inflammatory marker (high sensitive CRP: hsCRP). Results: Clinical characteristics (body mass index, total cholesterol/HDL-cholesterol and hsCRP) were unchanged in each group. However, FMD was significantly improved at 8 weeks after ALA therapy in both groups. Group I-baseline: 4 weeks: 8 weeks=4.1 ± 3.3:6.5 ± 2.2:8.0 ± 2.7, Group II-baseline: 4 weeks: 8 weeks=5.5 ± 3.7:7.4 ± 3.3:9.3 ± 2.7, p<0.05. The level of fibrinogen was observed to have an inverse correlation with FMD at 8 weeks after ALA therapy in Group I (p<0.05). Conclusion: ALA improves endothelial function in both diabetic and hypertensive patients.

KW - Alpha lipoic acid

KW - Hypertension

UR - http://www.scopus.com/inward/record.url?scp=33748767172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748767172&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 559

EP - 564

JO - Korean Circulation Journal

JF - Korean Circulation Journal

SN - 1738-5520

IS - 8

ER -