The effect of body mass index on survival in advanced epithelial ovarian cancer

Hyo Sook Bae, Jin-Hwa Hong, Kyoung Do Ki, Jae Yun Song, Jin Woo Shin, Jong Min Lee, Jae Kwan Lee, Nak Woo Lee, Chan Lee, Kyu Wan Lee, Yong Min Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for advanced (stage III and IV) EOC were reviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival and Cox regression analysis. Among all 236 patients, there were no differences in overall survival according to BMI except in underweight patients. In a multivariate Cox analysis, surgical optimality and underweight status were independent and significant prognostic factors for survival (HR, 2.302; 95% CI, 1.326-3.995; P=0.003 and HR, 8.622; 95% CI, 1.871-39.737; P=0.006, respectively). In the subgroup of serous histology and optimal surgery, overweight and obese I patients showed better survival than normal weight patients (P=0.012). We found that underweight BMI and surgical optimality are independent risk factors for the survival of patients with advanced ovarian cancer. High BMI groups (overweight, obese I and II) are not associated with the survival of advanced EOC patient. However, in the subgroup of EOC patients with serous histology and after optimal operation, overweight and obese I group patients show better survival than the normal weight group patients.

Original languageEnglish
Pages (from-to)793-797
Number of pages5
JournalJournal of Korean Medical Science
Volume29
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

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Body Mass Index
Survival
Thinness
Ovarian Neoplasms
Histology
Ovarian epithelial cancer
Obesity
Weights and Measures
Chi-Square Distribution
Medical Records
Analysis of Variance
Multivariate Analysis
Regression Analysis

Keywords

  • Body mass index
  • Obesity
  • Ovarian neoplasms
  • Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The effect of body mass index on survival in advanced epithelial ovarian cancer. / Bae, Hyo Sook; Hong, Jin-Hwa; Ki, Kyoung Do; Song, Jae Yun; Shin, Jin Woo; Lee, Jong Min; Lee, Jae Kwan; Lee, Nak Woo; Lee, Chan; Lee, Kyu Wan; Kim, Yong Min.

In: Journal of Korean Medical Science, Vol. 29, No. 6, 01.01.2014, p. 793-797.

Research output: Contribution to journalArticle

Bae, Hyo Sook ; Hong, Jin-Hwa ; Ki, Kyoung Do ; Song, Jae Yun ; Shin, Jin Woo ; Lee, Jong Min ; Lee, Jae Kwan ; Lee, Nak Woo ; Lee, Chan ; Lee, Kyu Wan ; Kim, Yong Min. / The effect of body mass index on survival in advanced epithelial ovarian cancer. In: Journal of Korean Medical Science. 2014 ; Vol. 29, No. 6. pp. 793-797.
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