The effect of caffeic acid phenethyl ester on the prevention of experimentally induced myringosclerosis

Jae-Jun Song, Seong Keun Kwon, Chang Gun Cho, Seok Won Park

Research output: Contribution to journalArticle

25 Citations (Scopus)


Objectives: Myringosclerosis is a common sequela of ventilation tube insertion for the treatment of the otitis media with effusion. Several antioxidants have been identified to prevent myringosclerosis. The objective of this study was to investigate the effect of caffeic acid phenethyl ester (CAPE) on the prevention of experimentally induced myringosclerosis. Methods: Thirty-five Sprague-Dawley rats were unilaterally myringotomized. The rats were divided into four groups randomly: group 1 received no treatment, group 2 received intraperitoneally administered saline and group 3 received intraperitoneally administered CAPE. The tympanic membranes were examined by otomicroscopy on the 15th day after treatment. The membranes were then harvested and evaluated histologically by light microscopy. Results: The tympanic membranes from group 1 showed extensive myringosclerosis; those from group 2 showed a similar occurrence of myringosclerosis. However, group 3 had a reduced occurrence of myringosclerosis by otomicroscopic evaluation. Under light microscopic examination, the lamina propria of the pars tensa was found to be thicker and more sclerotic in groups 1 and 2 when compared with group 3. Conclusions: Systemic treatment with CAPE was found to be effective in the prevention of sclerotic lesions in myringotomized rat tympanic membranes.

Original languageEnglish
Pages (from-to)1287-1291
Number of pages5
JournalInternational Journal of Pediatric Otorhinolaryngology
Issue number8
Publication statusPublished - 2007 Aug 1
Externally publishedYes



  • Antioxydants
  • Caffeic acid phenethyl ester
  • Myringosclerosis
  • Oxygen radicals

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Otorhinolaryngology

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