Abstract
1. 1. Smooth muscle contraction is mediated by an increase in the concentration of cytoplasmic free calcium. 2. 2. Low concentrations of caffeine can induce transient contraction of smooth muscle through the release of intracellular calcium from intracellular storage sites. 3. 3. The current study determined the effect of caffeine (0.4-100 μM) on the response of the in vitro whole bladder preparation to field stimulation (FS) at 0.6, 1.8, and 5.4 mM extracellular calcium. 4. 4. The following parameters were determined: basal pressure (BP), peak pressure response (PP), maximal rate of pressure generation (PR), maximal rate of bladder emptying (RE), and percent of volume emptied (VE). 5. 5. The results demonstrated that in the absence of caffeine, BP, PP, and PR were increased progressively as a function of both frequency of stimulation and the concentration of calcium. 6. 6. In addition, caffeine significantly increased the rate of pressure generation at 0.6 and 1.8 mm calcium.
| Original language | English |
|---|---|
| Pages (from-to) | 1007-1011 |
| Number of pages | 5 |
| Journal | General Pharmacology |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1993 Jan 1 |
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ASJC Scopus subject areas
- Pharmacology
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The effect of caffeine on the contractile response of the rabbit urinary bladder to field stimulation. / Lee, Jeong Gu; Wein, A. J.; Levin, R. M.
In: General Pharmacology, Vol. 24, No. 4, 01.01.1993, p. 1007-1011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of caffeine on the contractile response of the rabbit urinary bladder to field stimulation
AU - Lee, Jeong Gu
AU - Wein, A. J.
AU - Levin, R. M.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - 1. 1. Smooth muscle contraction is mediated by an increase in the concentration of cytoplasmic free calcium. 2. 2. Low concentrations of caffeine can induce transient contraction of smooth muscle through the release of intracellular calcium from intracellular storage sites. 3. 3. The current study determined the effect of caffeine (0.4-100 μM) on the response of the in vitro whole bladder preparation to field stimulation (FS) at 0.6, 1.8, and 5.4 mM extracellular calcium. 4. 4. The following parameters were determined: basal pressure (BP), peak pressure response (PP), maximal rate of pressure generation (PR), maximal rate of bladder emptying (RE), and percent of volume emptied (VE). 5. 5. The results demonstrated that in the absence of caffeine, BP, PP, and PR were increased progressively as a function of both frequency of stimulation and the concentration of calcium. 6. 6. In addition, caffeine significantly increased the rate of pressure generation at 0.6 and 1.8 mm calcium.
AB - 1. 1. Smooth muscle contraction is mediated by an increase in the concentration of cytoplasmic free calcium. 2. 2. Low concentrations of caffeine can induce transient contraction of smooth muscle through the release of intracellular calcium from intracellular storage sites. 3. 3. The current study determined the effect of caffeine (0.4-100 μM) on the response of the in vitro whole bladder preparation to field stimulation (FS) at 0.6, 1.8, and 5.4 mM extracellular calcium. 4. 4. The following parameters were determined: basal pressure (BP), peak pressure response (PP), maximal rate of pressure generation (PR), maximal rate of bladder emptying (RE), and percent of volume emptied (VE). 5. 5. The results demonstrated that in the absence of caffeine, BP, PP, and PR were increased progressively as a function of both frequency of stimulation and the concentration of calcium. 6. 6. In addition, caffeine significantly increased the rate of pressure generation at 0.6 and 1.8 mm calcium.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027317671&partnerID=8YFLogxK
U2 - 10.1016/0306-3623(93)90180-6
DO - 10.1016/0306-3623(93)90180-6
M3 - Article
VL - 24
SP - 1007
EP - 1011
JO - Vascular Pharmacology
JF - Vascular Pharmacology
SN - 1537-1891
IS - 4
ER -