The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast

Chao Feng, Xiguang Chen, Jing Zhang, Gangzheng Sun, Xiaojie Cheng, Zhiguo Wang, Hyun Jin Park

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In this study, different molecular weight (MW) carboxymethyl chitosans (CM-chitosan) nanoparticles were prepared by ionic gelification. The particle size of nanoparticles was around 180-250 nm by dynamic light scattering (DLS) and transmission electron microscope (TEM). With the increase of CM-chitosan nanoparticles concentration from 2 to 200 μg/mL, the growth inhibition effects on the keloid fibroblast increased. At the concentration of 100 μg/mL, CM-chitosan nanoparticles with MW6.3 kDa had a significant inhibitory effect (inhibition ratio 48.79%) of the proliferation of keloid fibroblast. Compared with CM-chitosan solution, the inhibition of CM-chitosan nanoparticles were lower in prior period and similar in later period. By analyzing the different effects of chitosan, CM-chitosan solution and CM-chitosan nanoparticles on proliferation of keloid fibroblast, we have found that the carboxylmethyl groups of CM-chitosan play an important role in inhibition of proliferation of keloid fibroblast.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalFrontiers of Chemistry in China
Volume6
Issue number1
DOIs
Publication statusPublished - 2011 Mar 1

Fingerprint

Fibroblasts
Nanoparticles
carboxymethyl-chitosan
Dynamic light scattering
Light transmission
Chitosan
Electron microscopes
Molecular weight
Particle size

Keywords

  • carboxymethyl-chitosan
  • keloid fibroblast
  • nanoparticle
  • proliferation

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast. / Feng, Chao; Chen, Xiguang; Zhang, Jing; Sun, Gangzheng; Cheng, Xiaojie; Wang, Zhiguo; Park, Hyun Jin.

In: Frontiers of Chemistry in China, Vol. 6, No. 1, 01.03.2011, p. 31-37.

Research output: Contribution to journalArticle

Feng, Chao ; Chen, Xiguang ; Zhang, Jing ; Sun, Gangzheng ; Cheng, Xiaojie ; Wang, Zhiguo ; Park, Hyun Jin. / The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast. In: Frontiers of Chemistry in China. 2011 ; Vol. 6, No. 1. pp. 31-37.
@article{54be94d15ad54efcb369dde4b9f92ca3,
title = "The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast",
abstract = "In this study, different molecular weight (MW) carboxymethyl chitosans (CM-chitosan) nanoparticles were prepared by ionic gelification. The particle size of nanoparticles was around 180-250 nm by dynamic light scattering (DLS) and transmission electron microscope (TEM). With the increase of CM-chitosan nanoparticles concentration from 2 to 200 μg/mL, the growth inhibition effects on the keloid fibroblast increased. At the concentration of 100 μg/mL, CM-chitosan nanoparticles with MW6.3 kDa had a significant inhibitory effect (inhibition ratio 48.79{\%}) of the proliferation of keloid fibroblast. Compared with CM-chitosan solution, the inhibition of CM-chitosan nanoparticles were lower in prior period and similar in later period. By analyzing the different effects of chitosan, CM-chitosan solution and CM-chitosan nanoparticles on proliferation of keloid fibroblast, we have found that the carboxylmethyl groups of CM-chitosan play an important role in inhibition of proliferation of keloid fibroblast.",
keywords = "carboxymethyl-chitosan, keloid fibroblast, nanoparticle, proliferation",
author = "Chao Feng and Xiguang Chen and Jing Zhang and Gangzheng Sun and Xiaojie Cheng and Zhiguo Wang and Park, {Hyun Jin}",
year = "2011",
month = "3",
day = "1",
doi = "10.1007/s11458-011-0229-6",
language = "English",
volume = "6",
pages = "31--37",
journal = "Frontiers of Chemistry in China",
issn = "1673-3495",
publisher = "Higher Education Press",
number = "1",

}

TY - JOUR

T1 - The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast

AU - Feng, Chao

AU - Chen, Xiguang

AU - Zhang, Jing

AU - Sun, Gangzheng

AU - Cheng, Xiaojie

AU - Wang, Zhiguo

AU - Park, Hyun Jin

PY - 2011/3/1

Y1 - 2011/3/1

N2 - In this study, different molecular weight (MW) carboxymethyl chitosans (CM-chitosan) nanoparticles were prepared by ionic gelification. The particle size of nanoparticles was around 180-250 nm by dynamic light scattering (DLS) and transmission electron microscope (TEM). With the increase of CM-chitosan nanoparticles concentration from 2 to 200 μg/mL, the growth inhibition effects on the keloid fibroblast increased. At the concentration of 100 μg/mL, CM-chitosan nanoparticles with MW6.3 kDa had a significant inhibitory effect (inhibition ratio 48.79%) of the proliferation of keloid fibroblast. Compared with CM-chitosan solution, the inhibition of CM-chitosan nanoparticles were lower in prior period and similar in later period. By analyzing the different effects of chitosan, CM-chitosan solution and CM-chitosan nanoparticles on proliferation of keloid fibroblast, we have found that the carboxylmethyl groups of CM-chitosan play an important role in inhibition of proliferation of keloid fibroblast.

AB - In this study, different molecular weight (MW) carboxymethyl chitosans (CM-chitosan) nanoparticles were prepared by ionic gelification. The particle size of nanoparticles was around 180-250 nm by dynamic light scattering (DLS) and transmission electron microscope (TEM). With the increase of CM-chitosan nanoparticles concentration from 2 to 200 μg/mL, the growth inhibition effects on the keloid fibroblast increased. At the concentration of 100 μg/mL, CM-chitosan nanoparticles with MW6.3 kDa had a significant inhibitory effect (inhibition ratio 48.79%) of the proliferation of keloid fibroblast. Compared with CM-chitosan solution, the inhibition of CM-chitosan nanoparticles were lower in prior period and similar in later period. By analyzing the different effects of chitosan, CM-chitosan solution and CM-chitosan nanoparticles on proliferation of keloid fibroblast, we have found that the carboxylmethyl groups of CM-chitosan play an important role in inhibition of proliferation of keloid fibroblast.

KW - carboxymethyl-chitosan

KW - keloid fibroblast

KW - nanoparticle

KW - proliferation

UR - http://www.scopus.com/inward/record.url?scp=79954633206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954633206&partnerID=8YFLogxK

U2 - 10.1007/s11458-011-0229-6

DO - 10.1007/s11458-011-0229-6

M3 - Article

AN - SCOPUS:79954633206

VL - 6

SP - 31

EP - 37

JO - Frontiers of Chemistry in China

JF - Frontiers of Chemistry in China

SN - 1673-3495

IS - 1

ER -