The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts

Xi Guang Chen, Zhen Wang, Wan Shun Liu, Hyun Jin Park

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

In this study, different molecular weight CM-chitosans were prepared and the effects on the growth and collagen secretion of normal skin fibroblasts and keloid fibroblasts were investigated in vitro. CM-chitosan promoted the proliferation of the normal skin fibroblast significantly but inhibited the proliferation of keloid fibroblast. The higher CM-chitosan concentration had a higher initial effect and the lower CM-chitosan concentration had a longer affecting time to the normal skin fibroblast. The lower molecular weight CM-chitosan had significant twofold activities. The CM-chitosan could reduce the ratio of type I/III collagen in keloid fibroblast by inhibiting the secretion of collagen type I; and had no effect on the secretion of types I and III collagen in the normal skin fibroblast.

Original languageEnglish
Pages (from-to)4609-4614
Number of pages6
JournalBiomaterials
Volume23
Issue number23
DOIs
Publication statusPublished - 2002 Dec

Keywords

  • Biomaterial
  • CM-chitosan
  • Collagen
  • Fibroblast
  • Keloid
  • Proliferation

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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