The effect of dim light at night on cerebral hemodynamic oscillations during sleep: A near-infrared spectroscopy study

Tae Joon Kim, Byeong Uk Lee, Jun Sang Sunwoo, Jung Ick Byun, Jangsup Moon, Soon Tae Lee, Keun Hwa Jung, Kon Chu, Manho Kim, Jong Min Lim, Eun Il Lee, Sang Kun Lee, Ki Young Jung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recent studies have reported that dim light at night (dLAN) is associated with risks of cardiovascular complications, such as hypertension and carotid atherosclerosis; however, little is known about the underlying mechanism. Here, we evaluated the effect of dLAN on the cerebrovascular system by analyzing cerebral hemodynamic oscillations using near-infrared spectroscopy (NIRS). Fourteen healthy male subjects underwent polysomnography coupled with cerebral NIRS. The data collected during sleep with dim light (10 lux) were compared with those collected during sleep under the control dark conditions for the sleep structure, cerebral hemodynamic oscillations, heart rate variability (HRV), and their electroencephalographic (EEG) power spectrum. Power spectral analysis was applied to oxy-hemoglobin concentrations calculated from the NIRS signal. Spectral densities over endothelial very-low-frequency oscillations (VLFOs) (0.003–0.02 Hz), neurogenic VLFOs (0.02–0.04 Hz), myogenic low-frequency oscillations (LFOs) (0.04–0.15 Hz), and total LFOs (0.003–0.15 Hz) were obtained for each sleep stage. The polysomnographic data revealed an increase in the N2 stage under the dLAN conditions. The spectral analysis of cerebral hemodynamics showed that the total LFOs increased significantly during slow-wave sleep (SWS) and decreased during rapid eye movement (REM) sleep. Specifically, endothelial (median of normalized value, 0.46 vs. 0.72, p = 0.019) and neurogenic (median, 0.58 vs. 0.84, p = 0.019) VLFOs were enhanced during SWS, whereas endothelial VLFOs (median, 1.93 vs. 1.47, p = 0.030) were attenuated during REM sleep. HRV analysis exhibited altered spectral densities during SWS induced by dLAN, including an increase in very-low-frequency and decreases in low-frequency and high-frequency ranges. In the EEG power spectral analysis, no significant difference was detected between the control and dLAN conditions. In conclusion, dLAN can disturb cerebral hemodynamics via the endothelial and autonomic systems without cortical involvement, predominantly during SWS, which might represent an underlying mechanism of the increased cerebrovascular risk associated with light exposure during sleep.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalChronobiology International
DOIs
Publication statusAccepted/In press - 2017 Oct 22

Fingerprint

Near-Infrared Spectroscopy
Sleep
Hemodynamics
Light
REM Sleep
Heart Rate
Carotid Artery Diseases
Polysomnography
Sleep Stages
Healthy Volunteers
Hemoglobins
Hypertension

Keywords

  • Cerebral hemodynamics
  • electroencephalographic spectral analysis
  • heart rate variability
  • light at night
  • near-infrared spectroscopy

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

The effect of dim light at night on cerebral hemodynamic oscillations during sleep : A near-infrared spectroscopy study. / Kim, Tae Joon; Lee, Byeong Uk; Sunwoo, Jun Sang; Byun, Jung Ick; Moon, Jangsup; Lee, Soon Tae; Jung, Keun Hwa; Chu, Kon; Kim, Manho; Lim, Jong Min; Lee, Eun Il; Lee, Sang Kun; Jung, Ki Young.

In: Chronobiology International, 22.10.2017, p. 1-14.

Research output: Contribution to journalArticle

Kim, TJ, Lee, BU, Sunwoo, JS, Byun, JI, Moon, J, Lee, ST, Jung, KH, Chu, K, Kim, M, Lim, JM, Lee, EI, Lee, SK & Jung, KY 2017, 'The effect of dim light at night on cerebral hemodynamic oscillations during sleep: A near-infrared spectroscopy study', Chronobiology International, pp. 1-14. https://doi.org/10.1080/07420528.2017.1363225
Kim, Tae Joon ; Lee, Byeong Uk ; Sunwoo, Jun Sang ; Byun, Jung Ick ; Moon, Jangsup ; Lee, Soon Tae ; Jung, Keun Hwa ; Chu, Kon ; Kim, Manho ; Lim, Jong Min ; Lee, Eun Il ; Lee, Sang Kun ; Jung, Ki Young. / The effect of dim light at night on cerebral hemodynamic oscillations during sleep : A near-infrared spectroscopy study. In: Chronobiology International. 2017 ; pp. 1-14.
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AU - Byun, Jung Ick

AU - Moon, Jangsup

AU - Lee, Soon Tae

AU - Jung, Keun Hwa

AU - Chu, Kon

AU - Kim, Manho

AU - Lim, Jong Min

AU - Lee, Eun Il

AU - Lee, Sang Kun

AU - Jung, Ki Young

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N2 - Recent studies have reported that dim light at night (dLAN) is associated with risks of cardiovascular complications, such as hypertension and carotid atherosclerosis; however, little is known about the underlying mechanism. Here, we evaluated the effect of dLAN on the cerebrovascular system by analyzing cerebral hemodynamic oscillations using near-infrared spectroscopy (NIRS). Fourteen healthy male subjects underwent polysomnography coupled with cerebral NIRS. The data collected during sleep with dim light (10 lux) were compared with those collected during sleep under the control dark conditions for the sleep structure, cerebral hemodynamic oscillations, heart rate variability (HRV), and their electroencephalographic (EEG) power spectrum. Power spectral analysis was applied to oxy-hemoglobin concentrations calculated from the NIRS signal. Spectral densities over endothelial very-low-frequency oscillations (VLFOs) (0.003–0.02 Hz), neurogenic VLFOs (0.02–0.04 Hz), myogenic low-frequency oscillations (LFOs) (0.04–0.15 Hz), and total LFOs (0.003–0.15 Hz) were obtained for each sleep stage. The polysomnographic data revealed an increase in the N2 stage under the dLAN conditions. The spectral analysis of cerebral hemodynamics showed that the total LFOs increased significantly during slow-wave sleep (SWS) and decreased during rapid eye movement (REM) sleep. Specifically, endothelial (median of normalized value, 0.46 vs. 0.72, p = 0.019) and neurogenic (median, 0.58 vs. 0.84, p = 0.019) VLFOs were enhanced during SWS, whereas endothelial VLFOs (median, 1.93 vs. 1.47, p = 0.030) were attenuated during REM sleep. HRV analysis exhibited altered spectral densities during SWS induced by dLAN, including an increase in very-low-frequency and decreases in low-frequency and high-frequency ranges. In the EEG power spectral analysis, no significant difference was detected between the control and dLAN conditions. In conclusion, dLAN can disturb cerebral hemodynamics via the endothelial and autonomic systems without cortical involvement, predominantly during SWS, which might represent an underlying mechanism of the increased cerebrovascular risk associated with light exposure during sleep.

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