Abstract
Background: It is unclear how the usage of topical steroid agents affects skin barrier function. Objective: In order to follow up on previous research into this topic, we sought to investigate the effects of a 3-week application of topical mometasone cream on the alteration of skin barrier function. Methods: Twenty-six patients who had been clinically diagnosed with, allergic contact dermatitis were enrolled. Topical mometasone cream was applied to the skin lesions. Clinical symptoms, transepidermal water loss (TEWL), corneometer unit, and pH value were measured on the initial visit, 1 week after treatment, and 3 weeks after treatment, and i their values were compared. Results: Clinical symptoms showed improvement after topical mometasone cream was applied (p<0.05), but Changes in TEWL, corneometer units, and pH values failed to show statistical significance (p>0.05). Conclusion: This study found that treatment with topical mometasone cream for 3 weeks has no effect on skin [barrier function. We believe that this research will help determine the optimal duration and dosage of topical steroid agents used for treating allergic contact dermatitis.
| Original language | English |
|---|---|
| Pages (from-to) | 347-350 |
| Number of pages | 4 |
| Journal | Korean Journal of Dermatology |
| Volume | 53 |
| Issue number | 5 |
| Publication status | Published - 2015 Jun 1 |
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Keywords
- Contact dermatitis
- Corneometer
- Mometasone furoate
- Skin barrier
- Transepidermal water loss (TEWL)
ASJC Scopus subject areas
- Dermatology
Cite this
The effect of mometasone furoate cream on skin barrier function in patients with allergic contact dermatitis. / So, Byoung Joon; Park, Jae Beom; Chun, Seung Hyun; Son, Sang Wook.
In: Korean Journal of Dermatology, Vol. 53, No. 5, 01.06.2015, p. 347-350.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of mometasone furoate cream on skin barrier function in patients with allergic contact dermatitis
AU - So, Byoung Joon
AU - Park, Jae Beom
AU - Chun, Seung Hyun
AU - Son, Sang Wook
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Background: It is unclear how the usage of topical steroid agents affects skin barrier function. Objective: In order to follow up on previous research into this topic, we sought to investigate the effects of a 3-week application of topical mometasone cream on the alteration of skin barrier function. Methods: Twenty-six patients who had been clinically diagnosed with, allergic contact dermatitis were enrolled. Topical mometasone cream was applied to the skin lesions. Clinical symptoms, transepidermal water loss (TEWL), corneometer unit, and pH value were measured on the initial visit, 1 week after treatment, and 3 weeks after treatment, and i their values were compared. Results: Clinical symptoms showed improvement after topical mometasone cream was applied (p<0.05), but Changes in TEWL, corneometer units, and pH values failed to show statistical significance (p>0.05). Conclusion: This study found that treatment with topical mometasone cream for 3 weeks has no effect on skin [barrier function. We believe that this research will help determine the optimal duration and dosage of topical steroid agents used for treating allergic contact dermatitis.
AB - Background: It is unclear how the usage of topical steroid agents affects skin barrier function. Objective: In order to follow up on previous research into this topic, we sought to investigate the effects of a 3-week application of topical mometasone cream on the alteration of skin barrier function. Methods: Twenty-six patients who had been clinically diagnosed with, allergic contact dermatitis were enrolled. Topical mometasone cream was applied to the skin lesions. Clinical symptoms, transepidermal water loss (TEWL), corneometer unit, and pH value were measured on the initial visit, 1 week after treatment, and 3 weeks after treatment, and i their values were compared. Results: Clinical symptoms showed improvement after topical mometasone cream was applied (p<0.05), but Changes in TEWL, corneometer units, and pH values failed to show statistical significance (p>0.05). Conclusion: This study found that treatment with topical mometasone cream for 3 weeks has no effect on skin [barrier function. We believe that this research will help determine the optimal duration and dosage of topical steroid agents used for treating allergic contact dermatitis.
KW - Contact dermatitis
KW - Corneometer
KW - Mometasone furoate
KW - Skin barrier
KW - Transepidermal water loss (TEWL)
UR - http://www.scopus.com/inward/record.url?scp=84938080545&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938080545&partnerID=8YFLogxK
M3 - Article
VL - 53
SP - 347
EP - 350
JO - Korean Journal of Dermatology
JF - Korean Journal of Dermatology
SN - 0494-4739
IS - 5
ER -