The effect of nefopam on postoperative fentanyl consumption: A randomized, double-blind study

Jee Youn Moon, Sang Sik Choi, Shin Young Lee, Mi Kyoung Lee, Jung Eun Kim, Ji Eun Lee, So Hyun Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Nefopam is a non-opioid, non-steroidal, centrally acting analgesic drug. The concomitant use of opioids and nefopam is believed to have many advantages over the administration of opioids alone for postoperative pain management. We conducted a randomized, double-blind study to determine the fentanylsparing effect of co-administration of nefopam with fentanyl for postoperative pain management via patient controlled analgesia (PCA). Methods: Ninety female patients who underwent laparoscopic total hysterectomy under general anesthesia were randomized into 3 groups, Group A, fentanyl 1,000 μg; Group B, fentanyl 500 μg + nefopam 200 mg; and Group C, fentanyl 500 μg + nefopam 400 mg, in a total volume of 100 ml PCA to be administered over the first 48 h postoperatively without basal infusion. The primary outcome was total fentanyl consumption during 48 h; secondary outcomes included pain scores and incidence of side effects. Results: Eighty-one patients were included in the analysis. The overall fentanyl-sparing effects of PCA with concomitant administration of nefopam during the first 48 h postoperatively were 54.5% in Group B and 48.9% group C. Fentanyl use was not significantly different between Groups B and C despite the difference in the nefopam dose. There were no differences among the three groups in terms of PCA-related side effects, although the overall sedation score of Group B was significantly lower than that of Group A. Conclusions: The concomitant administration of nefopam with fentanyl for postoperative pain management may allow reduction of fentanyl dose, thereby reducing the risk of opioid-related adverse effects.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalKorean Journal of Pain
Volume29
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Nefopam
Fentanyl
Double-Blind Method
Patient-Controlled Analgesia
Pain Management
Postoperative Pain
Opioid Analgesics
Hysterectomy
General Anesthesia
Analgesics

Keywords

  • Deep sedation
  • Double blind study
  • Hysterectomy
  • Nefopam
  • Opioids
  • Pain measurement
  • Patient-controlled analgesia
  • Postoperative pain

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

The effect of nefopam on postoperative fentanyl consumption : A randomized, double-blind study. / Moon, Jee Youn; Choi, Sang Sik; Lee, Shin Young; Lee, Mi Kyoung; Kim, Jung Eun; Lee, Ji Eun; Lee, So Hyun.

In: Korean Journal of Pain, Vol. 29, No. 2, 01.01.2016, p. 110-118.

Research output: Contribution to journalArticle

Moon, Jee Youn ; Choi, Sang Sik ; Lee, Shin Young ; Lee, Mi Kyoung ; Kim, Jung Eun ; Lee, Ji Eun ; Lee, So Hyun. / The effect of nefopam on postoperative fentanyl consumption : A randomized, double-blind study. In: Korean Journal of Pain. 2016 ; Vol. 29, No. 2. pp. 110-118.
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abstract = "Background: Nefopam is a non-opioid, non-steroidal, centrally acting analgesic drug. The concomitant use of opioids and nefopam is believed to have many advantages over the administration of opioids alone for postoperative pain management. We conducted a randomized, double-blind study to determine the fentanylsparing effect of co-administration of nefopam with fentanyl for postoperative pain management via patient controlled analgesia (PCA). Methods: Ninety female patients who underwent laparoscopic total hysterectomy under general anesthesia were randomized into 3 groups, Group A, fentanyl 1,000 μg; Group B, fentanyl 500 μg + nefopam 200 mg; and Group C, fentanyl 500 μg + nefopam 400 mg, in a total volume of 100 ml PCA to be administered over the first 48 h postoperatively without basal infusion. The primary outcome was total fentanyl consumption during 48 h; secondary outcomes included pain scores and incidence of side effects. Results: Eighty-one patients were included in the analysis. The overall fentanyl-sparing effects of PCA with concomitant administration of nefopam during the first 48 h postoperatively were 54.5{\%} in Group B and 48.9{\%} group C. Fentanyl use was not significantly different between Groups B and C despite the difference in the nefopam dose. There were no differences among the three groups in terms of PCA-related side effects, although the overall sedation score of Group B was significantly lower than that of Group A. Conclusions: The concomitant administration of nefopam with fentanyl for postoperative pain management may allow reduction of fentanyl dose, thereby reducing the risk of opioid-related adverse effects.",
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AU - Choi, Sang Sik

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AU - Lee, Mi Kyoung

AU - Kim, Jung Eun

AU - Lee, Ji Eun

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N2 - Background: Nefopam is a non-opioid, non-steroidal, centrally acting analgesic drug. The concomitant use of opioids and nefopam is believed to have many advantages over the administration of opioids alone for postoperative pain management. We conducted a randomized, double-blind study to determine the fentanylsparing effect of co-administration of nefopam with fentanyl for postoperative pain management via patient controlled analgesia (PCA). Methods: Ninety female patients who underwent laparoscopic total hysterectomy under general anesthesia were randomized into 3 groups, Group A, fentanyl 1,000 μg; Group B, fentanyl 500 μg + nefopam 200 mg; and Group C, fentanyl 500 μg + nefopam 400 mg, in a total volume of 100 ml PCA to be administered over the first 48 h postoperatively without basal infusion. The primary outcome was total fentanyl consumption during 48 h; secondary outcomes included pain scores and incidence of side effects. Results: Eighty-one patients were included in the analysis. The overall fentanyl-sparing effects of PCA with concomitant administration of nefopam during the first 48 h postoperatively were 54.5% in Group B and 48.9% group C. Fentanyl use was not significantly different between Groups B and C despite the difference in the nefopam dose. There were no differences among the three groups in terms of PCA-related side effects, although the overall sedation score of Group B was significantly lower than that of Group A. Conclusions: The concomitant administration of nefopam with fentanyl for postoperative pain management may allow reduction of fentanyl dose, thereby reducing the risk of opioid-related adverse effects.

AB - Background: Nefopam is a non-opioid, non-steroidal, centrally acting analgesic drug. The concomitant use of opioids and nefopam is believed to have many advantages over the administration of opioids alone for postoperative pain management. We conducted a randomized, double-blind study to determine the fentanylsparing effect of co-administration of nefopam with fentanyl for postoperative pain management via patient controlled analgesia (PCA). Methods: Ninety female patients who underwent laparoscopic total hysterectomy under general anesthesia were randomized into 3 groups, Group A, fentanyl 1,000 μg; Group B, fentanyl 500 μg + nefopam 200 mg; and Group C, fentanyl 500 μg + nefopam 400 mg, in a total volume of 100 ml PCA to be administered over the first 48 h postoperatively without basal infusion. The primary outcome was total fentanyl consumption during 48 h; secondary outcomes included pain scores and incidence of side effects. Results: Eighty-one patients were included in the analysis. The overall fentanyl-sparing effects of PCA with concomitant administration of nefopam during the first 48 h postoperatively were 54.5% in Group B and 48.9% group C. Fentanyl use was not significantly different between Groups B and C despite the difference in the nefopam dose. There were no differences among the three groups in terms of PCA-related side effects, although the overall sedation score of Group B was significantly lower than that of Group A. Conclusions: The concomitant administration of nefopam with fentanyl for postoperative pain management may allow reduction of fentanyl dose, thereby reducing the risk of opioid-related adverse effects.

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KW - Double blind study

KW - Hysterectomy

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KW - Opioids

KW - Pain measurement

KW - Patient-controlled analgesia

KW - Postoperative pain

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