The effect of nefopam on postoperative fentanyl consumption: A randomized, double-blind study

Jee Youn Moon, Sang Sik Choi, Shin Young Lee, Mi Kyung Lee, Jung Eun Kim, Ji Eun Lee, So Hyun Lee

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background: Nefopam is a non-opioid, non-steroidal, centrally acting analgesic drug. The concomitant use of opioids and nefopam is believed to have many advantages over the administration of opioids alone for postoperative pain management. We conducted a randomized, double-blind study to determine the fentanylsparing effect of co-administration of nefopam with fentanyl for postoperative pain management via patient controlled analgesia (PCA). Methods: Ninety female patients who underwent laparoscopic total hysterectomy under general anesthesia were randomized into 3 groups, Group A, fentanyl 1,000 μg; Group B, fentanyl 500 μg + nefopam 200 mg; and Group C, fentanyl 500 μg + nefopam 400 mg, in a total volume of 100 ml PCA to be administered over the first 48 h postoperatively without basal infusion. The primary outcome was total fentanyl consumption during 48 h; secondary outcomes included pain scores and incidence of side effects. Results: Eighty-one patients were included in the analysis. The overall fentanyl-sparing effects of PCA with concomitant administration of nefopam during the first 48 h postoperatively were 54.5% in Group B and 48.9% group C. Fentanyl use was not significantly different between Groups B and C despite the difference in the nefopam dose. There were no differences among the three groups in terms of PCA-related side effects, although the overall sedation score of Group B was significantly lower than that of Group A. Conclusions: The concomitant administration of nefopam with fentanyl for postoperative pain management may allow reduction of fentanyl dose, thereby reducing the risk of opioid-related adverse effects.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalKorean Journal of Pain
Issue number2
Publication statusPublished - 2016
Externally publishedYes


  • Deep sedation
  • Double blind study
  • Hysterectomy
  • Nefopam
  • Opioids
  • Pain measurement
  • Patient-controlled analgesia
  • Postoperative pain

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


Dive into the research topics of 'The effect of nefopam on postoperative fentanyl consumption: A randomized, double-blind study'. Together they form a unique fingerprint.

Cite this