The effect of oral administration of alpha lipoic acid and alpha lipoic acid coated stent in porcine in-stent restenosis model

Sang Yeob Lim, Eun Hui Bae, Myung Ho Jeong, Ju Han Kim, Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang, Dong Lyun Cho, Ki Seok Kim, Seung Jae Joo

Research output: Contribution to journalArticle

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Abstract

Background and Objectives: Alpha lipoic acid (ALA) is beneficial for improving endothelial dysfunction and preventing atherosclerosis-related diseases. We evaluated the affect of ALA on stent restenosis in a porcine model. Materials and Methods: The First experiment: Balloon overdilation injuries were performed in two coronary arteries in 12 pigs. Four weeks after the balloon overdilation injury, 24 bare metal stents were placed for 24 injured coronary arteries. We randomized into two groups (12 stents per group; control group: aspirin and clopidogrel only, ALA group: aspirin and clopidogrel plus 100 mg/kg ALA during 4 weeks). The Second experiment: Stents were randomly implanted in 2 coronary arteries in 8 pigs. Group I was the control stent group (n=8), and group II was the ALA coated stent group (n=8). Follow-up coronary angiogram and histopathologic assessment were performed at 4 weeks after stenting in both experiments. Results: The First experiment On histopathologic analysis, the injury score and internal elastic lamina area did not differ significantly between the two groups. The neointimal area was 7.3 ± 0.9 mm2 in the control group and 2.2±1.1 mm2 in the ALA group (p<0.001), and the histopathologic area of stenosis was 75.9±8.5% in the control group and 23.5±10.5% in the ALA group (p<0.001). The Second experiment: The injury score and internal elastic lamina area were not significantly different between the two groups. The neointimal area was 7.4±1.1 mm2 in the control group and 1.4±0.8 mm 2 in the ALA group (p<0.001), and the histopathologic area of stenosis was 77.6±10.9% in the control group and 15.6±7.6% in the ALA group (p<0.001). Conclusion: Both a high dose of oral ALA and ALA coated stents inhibited neointimal hyperplasia in this porcine coronary artery stent restenosis model.

Original languageEnglish
Pages (from-to)495-502
Number of pages8
JournalKorean Circulation Journal
Volume36
Issue number7
Publication statusPublished - 2006 Jul 1
Externally publishedYes

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Thioctic Acid
Stents
Oral Administration
Swine
clopidogrel
Control Groups
Coronary Vessels
Wounds and Injuries
Aspirin
Pathologic Constriction
Hyperplasia
Atherosclerosis
Angiography
Metals

Keywords

  • Anti-oxidants
  • Coronary disease
  • Restenosis
  • Stents

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

The effect of oral administration of alpha lipoic acid and alpha lipoic acid coated stent in porcine in-stent restenosis model. / Lim, Sang Yeob; Bae, Eun Hui; Jeong, Myung Ho; Kim, Ju Han; Ahn, Youngkeun; Cho, Jeong Gwan; Park, Jong Chun; Kang, Jung Chaee; Cho, Dong Lyun; Kim, Ki Seok; Joo, Seung Jae.

In: Korean Circulation Journal, Vol. 36, No. 7, 01.07.2006, p. 495-502.

Research output: Contribution to journalArticle

Lim, SY, Bae, EH, Jeong, MH, Kim, JH, Ahn, Y, Cho, JG, Park, JC, Kang, JC, Cho, DL, Kim, KS & Joo, SJ 2006, 'The effect of oral administration of alpha lipoic acid and alpha lipoic acid coated stent in porcine in-stent restenosis model', Korean Circulation Journal, vol. 36, no. 7, pp. 495-502.
Lim, Sang Yeob ; Bae, Eun Hui ; Jeong, Myung Ho ; Kim, Ju Han ; Ahn, Youngkeun ; Cho, Jeong Gwan ; Park, Jong Chun ; Kang, Jung Chaee ; Cho, Dong Lyun ; Kim, Ki Seok ; Joo, Seung Jae. / The effect of oral administration of alpha lipoic acid and alpha lipoic acid coated stent in porcine in-stent restenosis model. In: Korean Circulation Journal. 2006 ; Vol. 36, No. 7. pp. 495-502.
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abstract = "Background and Objectives: Alpha lipoic acid (ALA) is beneficial for improving endothelial dysfunction and preventing atherosclerosis-related diseases. We evaluated the affect of ALA on stent restenosis in a porcine model. Materials and Methods: The First experiment: Balloon overdilation injuries were performed in two coronary arteries in 12 pigs. Four weeks after the balloon overdilation injury, 24 bare metal stents were placed for 24 injured coronary arteries. We randomized into two groups (12 stents per group; control group: aspirin and clopidogrel only, ALA group: aspirin and clopidogrel plus 100 mg/kg ALA during 4 weeks). The Second experiment: Stents were randomly implanted in 2 coronary arteries in 8 pigs. Group I was the control stent group (n=8), and group II was the ALA coated stent group (n=8). Follow-up coronary angiogram and histopathologic assessment were performed at 4 weeks after stenting in both experiments. Results: The First experiment On histopathologic analysis, the injury score and internal elastic lamina area did not differ significantly between the two groups. The neointimal area was 7.3 ± 0.9 mm2 in the control group and 2.2±1.1 mm2 in the ALA group (p<0.001), and the histopathologic area of stenosis was 75.9±8.5{\%} in the control group and 23.5±10.5{\%} in the ALA group (p<0.001). The Second experiment: The injury score and internal elastic lamina area were not significantly different between the two groups. The neointimal area was 7.4±1.1 mm2 in the control group and 1.4±0.8 mm 2 in the ALA group (p<0.001), and the histopathologic area of stenosis was 77.6±10.9{\%} in the control group and 15.6±7.6{\%} in the ALA group (p<0.001). Conclusion: Both a high dose of oral ALA and ALA coated stents inhibited neointimal hyperplasia in this porcine coronary artery stent restenosis model.",
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AU - Lim, Sang Yeob

AU - Bae, Eun Hui

AU - Jeong, Myung Ho

AU - Kim, Ju Han

AU - Ahn, Youngkeun

AU - Cho, Jeong Gwan

AU - Park, Jong Chun

AU - Kang, Jung Chaee

AU - Cho, Dong Lyun

AU - Kim, Ki Seok

AU - Joo, Seung Jae

PY - 2006/7/1

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N2 - Background and Objectives: Alpha lipoic acid (ALA) is beneficial for improving endothelial dysfunction and preventing atherosclerosis-related diseases. We evaluated the affect of ALA on stent restenosis in a porcine model. Materials and Methods: The First experiment: Balloon overdilation injuries were performed in two coronary arteries in 12 pigs. Four weeks after the balloon overdilation injury, 24 bare metal stents were placed for 24 injured coronary arteries. We randomized into two groups (12 stents per group; control group: aspirin and clopidogrel only, ALA group: aspirin and clopidogrel plus 100 mg/kg ALA during 4 weeks). The Second experiment: Stents were randomly implanted in 2 coronary arteries in 8 pigs. Group I was the control stent group (n=8), and group II was the ALA coated stent group (n=8). Follow-up coronary angiogram and histopathologic assessment were performed at 4 weeks after stenting in both experiments. Results: The First experiment On histopathologic analysis, the injury score and internal elastic lamina area did not differ significantly between the two groups. The neointimal area was 7.3 ± 0.9 mm2 in the control group and 2.2±1.1 mm2 in the ALA group (p<0.001), and the histopathologic area of stenosis was 75.9±8.5% in the control group and 23.5±10.5% in the ALA group (p<0.001). The Second experiment: The injury score and internal elastic lamina area were not significantly different between the two groups. The neointimal area was 7.4±1.1 mm2 in the control group and 1.4±0.8 mm 2 in the ALA group (p<0.001), and the histopathologic area of stenosis was 77.6±10.9% in the control group and 15.6±7.6% in the ALA group (p<0.001). Conclusion: Both a high dose of oral ALA and ALA coated stents inhibited neointimal hyperplasia in this porcine coronary artery stent restenosis model.

AB - Background and Objectives: Alpha lipoic acid (ALA) is beneficial for improving endothelial dysfunction and preventing atherosclerosis-related diseases. We evaluated the affect of ALA on stent restenosis in a porcine model. Materials and Methods: The First experiment: Balloon overdilation injuries were performed in two coronary arteries in 12 pigs. Four weeks after the balloon overdilation injury, 24 bare metal stents were placed for 24 injured coronary arteries. We randomized into two groups (12 stents per group; control group: aspirin and clopidogrel only, ALA group: aspirin and clopidogrel plus 100 mg/kg ALA during 4 weeks). The Second experiment: Stents were randomly implanted in 2 coronary arteries in 8 pigs. Group I was the control stent group (n=8), and group II was the ALA coated stent group (n=8). Follow-up coronary angiogram and histopathologic assessment were performed at 4 weeks after stenting in both experiments. Results: The First experiment On histopathologic analysis, the injury score and internal elastic lamina area did not differ significantly between the two groups. The neointimal area was 7.3 ± 0.9 mm2 in the control group and 2.2±1.1 mm2 in the ALA group (p<0.001), and the histopathologic area of stenosis was 75.9±8.5% in the control group and 23.5±10.5% in the ALA group (p<0.001). The Second experiment: The injury score and internal elastic lamina area were not significantly different between the two groups. The neointimal area was 7.4±1.1 mm2 in the control group and 1.4±0.8 mm 2 in the ALA group (p<0.001), and the histopathologic area of stenosis was 77.6±10.9% in the control group and 15.6±7.6% in the ALA group (p<0.001). Conclusion: Both a high dose of oral ALA and ALA coated stents inhibited neointimal hyperplasia in this porcine coronary artery stent restenosis model.

KW - Anti-oxidants

KW - Coronary disease

KW - Restenosis

KW - Stents

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