The effect of oral isotretinoin on the barrier function of the lips of acne patients and the protective role of moisturizer

Research output: Contribution to journalArticle

Abstract

Background: Oral isotretinoin is an effective treatment for acne patients, and this agent may cause variable side effects. Among them, cheilitis is the most common symptom that occurs in virtually all these patients. Objective: We wanted to assess the functional changes of the lips of acne patients who were treated with oral isotretinoin by measuring the transepidermal water loss (TEWL), and we evaluated the benefit of using a moisturizing cream as an adjunctive treatment to oral isotretinoin. Methods: We measured the TEWL of the lips and cheeks in 17 acne patients who were treated with oral isotretinoin for 6 weeks. Then we compared the changes of the patients and the differences of the TEWL of the lip according to the dose of isotretinoin. In addition, we compared the TEWL change of the lips between 10 patients who were treated with oral isotretinoin and moisturizer cream (PHYSIOGEL® A.I. Cream) with that of 10 patients who received only isotretinoin. Results: The TEWL of the lip increased significantly during isotretinoin treatment while the TEWL of the cheek showed no noticeable increase. The increase of the TEWL of the lip was more definite in the 20 mg isotretinoin group than that of the 10 mg isotretinoin group. However, the TEWL of the lip remained stable in the patients treated with oral isotretinoin and moisturizer cream. Conclusion: The lips are vulnerable to the mechanism of isotretinoin due to the poor barrier function of the parakeratotic mucosal epithelium with incomplete corneocyte formation. Therefore, regular use of moisturizer on the lips is recommended as an adjunctive treatment along with oral isotretinoin. (Korean J Dermatol 2008;46(10):1353-1356).

Original languageEnglish
Pages (from-to)1353-1356
Number of pages4
JournalKorean Journal of Dermatology
Volume46
Issue number10
Publication statusPublished - 2008 Oct 1

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Isotretinoin
Acne Vulgaris
Lip
Water
Cheek
Cheilitis
Proxy
Therapeutics

Keywords

  • Cheilitis
  • Isotretinoin
  • Lip
  • Moisturizer
  • Transepidermal water loss

ASJC Scopus subject areas

  • Dermatology

Cite this

@article{713905e8430240c2b307cc78c9cab810,
title = "The effect of oral isotretinoin on the barrier function of the lips of acne patients and the protective role of moisturizer",
abstract = "Background: Oral isotretinoin is an effective treatment for acne patients, and this agent may cause variable side effects. Among them, cheilitis is the most common symptom that occurs in virtually all these patients. Objective: We wanted to assess the functional changes of the lips of acne patients who were treated with oral isotretinoin by measuring the transepidermal water loss (TEWL), and we evaluated the benefit of using a moisturizing cream as an adjunctive treatment to oral isotretinoin. Methods: We measured the TEWL of the lips and cheeks in 17 acne patients who were treated with oral isotretinoin for 6 weeks. Then we compared the changes of the patients and the differences of the TEWL of the lip according to the dose of isotretinoin. In addition, we compared the TEWL change of the lips between 10 patients who were treated with oral isotretinoin and moisturizer cream (PHYSIOGEL{\circledR} A.I. Cream) with that of 10 patients who received only isotretinoin. Results: The TEWL of the lip increased significantly during isotretinoin treatment while the TEWL of the cheek showed no noticeable increase. The increase of the TEWL of the lip was more definite in the 20 mg isotretinoin group than that of the 10 mg isotretinoin group. However, the TEWL of the lip remained stable in the patients treated with oral isotretinoin and moisturizer cream. Conclusion: The lips are vulnerable to the mechanism of isotretinoin due to the poor barrier function of the parakeratotic mucosal epithelium with incomplete corneocyte formation. Therefore, regular use of moisturizer on the lips is recommended as an adjunctive treatment along with oral isotretinoin. (Korean J Dermatol 2008;46(10):1353-1356).",
keywords = "Cheilitis, Isotretinoin, Lip, Moisturizer, Transepidermal water loss",
author = "Choi, {Jae Eun} and Soo-Hong Seo and Son, {Sang Wook} and Il-Hwan Kim",
year = "2008",
month = "10",
day = "1",
language = "English",
volume = "46",
pages = "1353--1356",
journal = "Korean Journal of Dermatology",
issn = "0494-4739",
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TY - JOUR

T1 - The effect of oral isotretinoin on the barrier function of the lips of acne patients and the protective role of moisturizer

AU - Choi, Jae Eun

AU - Seo, Soo-Hong

AU - Son, Sang Wook

AU - Kim, Il-Hwan

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Background: Oral isotretinoin is an effective treatment for acne patients, and this agent may cause variable side effects. Among them, cheilitis is the most common symptom that occurs in virtually all these patients. Objective: We wanted to assess the functional changes of the lips of acne patients who were treated with oral isotretinoin by measuring the transepidermal water loss (TEWL), and we evaluated the benefit of using a moisturizing cream as an adjunctive treatment to oral isotretinoin. Methods: We measured the TEWL of the lips and cheeks in 17 acne patients who were treated with oral isotretinoin for 6 weeks. Then we compared the changes of the patients and the differences of the TEWL of the lip according to the dose of isotretinoin. In addition, we compared the TEWL change of the lips between 10 patients who were treated with oral isotretinoin and moisturizer cream (PHYSIOGEL® A.I. Cream) with that of 10 patients who received only isotretinoin. Results: The TEWL of the lip increased significantly during isotretinoin treatment while the TEWL of the cheek showed no noticeable increase. The increase of the TEWL of the lip was more definite in the 20 mg isotretinoin group than that of the 10 mg isotretinoin group. However, the TEWL of the lip remained stable in the patients treated with oral isotretinoin and moisturizer cream. Conclusion: The lips are vulnerable to the mechanism of isotretinoin due to the poor barrier function of the parakeratotic mucosal epithelium with incomplete corneocyte formation. Therefore, regular use of moisturizer on the lips is recommended as an adjunctive treatment along with oral isotretinoin. (Korean J Dermatol 2008;46(10):1353-1356).

AB - Background: Oral isotretinoin is an effective treatment for acne patients, and this agent may cause variable side effects. Among them, cheilitis is the most common symptom that occurs in virtually all these patients. Objective: We wanted to assess the functional changes of the lips of acne patients who were treated with oral isotretinoin by measuring the transepidermal water loss (TEWL), and we evaluated the benefit of using a moisturizing cream as an adjunctive treatment to oral isotretinoin. Methods: We measured the TEWL of the lips and cheeks in 17 acne patients who were treated with oral isotretinoin for 6 weeks. Then we compared the changes of the patients and the differences of the TEWL of the lip according to the dose of isotretinoin. In addition, we compared the TEWL change of the lips between 10 patients who were treated with oral isotretinoin and moisturizer cream (PHYSIOGEL® A.I. Cream) with that of 10 patients who received only isotretinoin. Results: The TEWL of the lip increased significantly during isotretinoin treatment while the TEWL of the cheek showed no noticeable increase. The increase of the TEWL of the lip was more definite in the 20 mg isotretinoin group than that of the 10 mg isotretinoin group. However, the TEWL of the lip remained stable in the patients treated with oral isotretinoin and moisturizer cream. Conclusion: The lips are vulnerable to the mechanism of isotretinoin due to the poor barrier function of the parakeratotic mucosal epithelium with incomplete corneocyte formation. Therefore, regular use of moisturizer on the lips is recommended as an adjunctive treatment along with oral isotretinoin. (Korean J Dermatol 2008;46(10):1353-1356).

KW - Cheilitis

KW - Isotretinoin

KW - Lip

KW - Moisturizer

KW - Transepidermal water loss

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VL - 46

SP - 1353

EP - 1356

JO - Korean Journal of Dermatology

JF - Korean Journal of Dermatology

SN - 0494-4739

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