The effect of organic solvents on the determination of cyclic boronates of some β-blockers by gas chromatography/mass spectrometry

Jeong Ae Lee, Dong Seok Lho, Myungsoo Kim, Keon Kim, Yunje Kim

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Formation cyclic boronates for β-blockers, by use of triethylamine (TEA) and pyridine as catalysts, gives more effective product yield. Eleven β-blockers, formed by cyclic boronation with n-butylboronic acid and TEA, produced higher yields than by on-column thermal reaction and seven β-blockers were shown to give the highest yields in the phenyl cyclic boronation with pyridine or TEA by on-column thermal and general reaction. The phenyl cyclic boronate of nadolol produced one peak in the chromatogram and the n-butyl cyclic boronate showed two peaks. On-column derivatization with n-butylboronic acid and pyridine was effective in saving analysis time and for convenience, even though some n-butyl cyclic boronates by cyclic boronation with TEA gave a better yield. In n-butyl cyclic boronation with pyridine by on-column thermal reaction the detection limits were 0.1 to 4 ng/μL in urine with a signal-to-noise ratio of 10:1.

Original languageEnglish
Pages (from-to)1150-1160
Number of pages11
JournalRapid Communications in Mass Spectrometry
Volume12
Issue number17
DOIs
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

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