The effect of platelet rich plasma on osteogenesis in a long bone segmental defect: Is the platelet rich plasma effective for bone reconstruction?

Hae Ryong Song, Ji Hoon Bae, Jae Hak Park, Min Cheol Choi, Swee H. Teoh, Hak Jun Kim, Hong Chul Lim, Dong Ho Kum

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2 Citations (Scopus)


The effect of platelet rich plasma (PRP) on osteogenesis in the defect of long bone is controversial. The purpose of this study was to investigate the effect of PRP on new bone formation in a segmental defect of rabbit ulna. Unilateral 15 mm mid-diaphyseal defect was created in the ulna of twenty skeletally mature New Zealand White rabbits. The defects in ten rabbits each were treated with autogenous PRP in a polycarprolactone scaffold (PRP treated group) and remain empty defect without any material (contol group). 12 weeks and 20 weeks after surgery, five rabbits in each group were sacrificed to assess new bone formation. New bone formation assessed by plain radiography, microCT scan and histology did not differ significantly between PRP treated group and control group. This study demonstrated that PRP alone had no evidence of promoting osteogenesis in a long bone segmental defect of rabbit ulna.

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalTissue Engineering and Regenerative Medicine
Issue number4
Publication statusPublished - 2010 Aug 1



  • Defect
  • New bone
  • Osteogenesis
  • Platelet rich plasma
  • Rabbit

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

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