The effect of radiation on the immune response to cancers

Bonggoo Park, Cassian Yee, Kyung-Mi Lee

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

In cancer patients undergoing radiation therapy, the beneficial effects of radiation can extend beyond direct cytotoxicity to tumor cells. Delivery of localized radiation to tumors often leads to systemic responses at distant sites, a phenomenon known as the abscopal effect which has been attributed to the induction and enhancement of the endogenous anti-tumor innate and adaptive immune response. The mechanisms surrounding the abscopal effect are diverse and include trafficking of lymphocytes into the tumor microenvironment, enhanced tumor recognition and killing via up-regulation of tumor antigens and antigen presenting machinery and, induction of positive immunomodulatory pathways. Here, we discuss potential mechanisms of radiation-induced enhancement of the anti-tumor response through its effect on the host immune system and explore potential combinational immune-based strategies such as adoptive cellular therapy using ex vivo expanded NK and T cells as a means of delivering a potent effector population in the context of radiation-enhanced anti-tumor immune environment.

Original languageEnglish
Pages (from-to)927-943
Number of pages17
JournalInternational Journal of Molecular Sciences
Volume15
Issue number1
DOIs
Publication statusPublished - 2014 Jan 10

Fingerprint

Radiation Effects
Tumors
tumors
cancer
Radiation
radiation
Neoplasms
antigens
Antigens
induction
Tumor Microenvironment
T-cells
Lymphocytes
effectors
Immune system
immune systems
Radiotherapy
Adaptive Immunity
Neoplasm Antigens
Cytotoxicity

Keywords

  • Abscopal effect
  • Cell therapy
  • Radiation
  • Recognition
  • Trafficking

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

The effect of radiation on the immune response to cancers. / Park, Bonggoo; Yee, Cassian; Lee, Kyung-Mi.

In: International Journal of Molecular Sciences, Vol. 15, No. 1, 10.01.2014, p. 927-943.

Research output: Contribution to journalArticle

@article{1730d42c97ab4c89b2fd3c1a4dcb357c,
title = "The effect of radiation on the immune response to cancers",
abstract = "In cancer patients undergoing radiation therapy, the beneficial effects of radiation can extend beyond direct cytotoxicity to tumor cells. Delivery of localized radiation to tumors often leads to systemic responses at distant sites, a phenomenon known as the abscopal effect which has been attributed to the induction and enhancement of the endogenous anti-tumor innate and adaptive immune response. The mechanisms surrounding the abscopal effect are diverse and include trafficking of lymphocytes into the tumor microenvironment, enhanced tumor recognition and killing via up-regulation of tumor antigens and antigen presenting machinery and, induction of positive immunomodulatory pathways. Here, we discuss potential mechanisms of radiation-induced enhancement of the anti-tumor response through its effect on the host immune system and explore potential combinational immune-based strategies such as adoptive cellular therapy using ex vivo expanded NK and T cells as a means of delivering a potent effector population in the context of radiation-enhanced anti-tumor immune environment.",
keywords = "Abscopal effect, Cell therapy, Radiation, Recognition, Trafficking",
author = "Bonggoo Park and Cassian Yee and Kyung-Mi Lee",
year = "2014",
month = "1",
day = "10",
doi = "10.3390/ijms15010927",
language = "English",
volume = "15",
pages = "927--943",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",

}

TY - JOUR

T1 - The effect of radiation on the immune response to cancers

AU - Park, Bonggoo

AU - Yee, Cassian

AU - Lee, Kyung-Mi

PY - 2014/1/10

Y1 - 2014/1/10

N2 - In cancer patients undergoing radiation therapy, the beneficial effects of radiation can extend beyond direct cytotoxicity to tumor cells. Delivery of localized radiation to tumors often leads to systemic responses at distant sites, a phenomenon known as the abscopal effect which has been attributed to the induction and enhancement of the endogenous anti-tumor innate and adaptive immune response. The mechanisms surrounding the abscopal effect are diverse and include trafficking of lymphocytes into the tumor microenvironment, enhanced tumor recognition and killing via up-regulation of tumor antigens and antigen presenting machinery and, induction of positive immunomodulatory pathways. Here, we discuss potential mechanisms of radiation-induced enhancement of the anti-tumor response through its effect on the host immune system and explore potential combinational immune-based strategies such as adoptive cellular therapy using ex vivo expanded NK and T cells as a means of delivering a potent effector population in the context of radiation-enhanced anti-tumor immune environment.

AB - In cancer patients undergoing radiation therapy, the beneficial effects of radiation can extend beyond direct cytotoxicity to tumor cells. Delivery of localized radiation to tumors often leads to systemic responses at distant sites, a phenomenon known as the abscopal effect which has been attributed to the induction and enhancement of the endogenous anti-tumor innate and adaptive immune response. The mechanisms surrounding the abscopal effect are diverse and include trafficking of lymphocytes into the tumor microenvironment, enhanced tumor recognition and killing via up-regulation of tumor antigens and antigen presenting machinery and, induction of positive immunomodulatory pathways. Here, we discuss potential mechanisms of radiation-induced enhancement of the anti-tumor response through its effect on the host immune system and explore potential combinational immune-based strategies such as adoptive cellular therapy using ex vivo expanded NK and T cells as a means of delivering a potent effector population in the context of radiation-enhanced anti-tumor immune environment.

KW - Abscopal effect

KW - Cell therapy

KW - Radiation

KW - Recognition

KW - Trafficking

UR - http://www.scopus.com/inward/record.url?scp=84892412579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892412579&partnerID=8YFLogxK

U2 - 10.3390/ijms15010927

DO - 10.3390/ijms15010927

M3 - Article

C2 - 24434638

AN - SCOPUS:84892412579

VL - 15

SP - 927

EP - 943

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 1

ER -