The effect of radiation on the immune response to cancers

Bonggoo Park, Cassian Yee, Kyung Mi Lee

Research output: Contribution to journalReview article

120 Citations (Scopus)

Abstract

In cancer patients undergoing radiation therapy, the beneficial effects of radiation can extend beyond direct cytotoxicity to tumor cells. Delivery of localized radiation to tumors often leads to systemic responses at distant sites, a phenomenon known as the abscopal effect which has been attributed to the induction and enhancement of the endogenous anti-tumor innate and adaptive immune response. The mechanisms surrounding the abscopal effect are diverse and include trafficking of lymphocytes into the tumor microenvironment, enhanced tumor recognition and killing via up-regulation of tumor antigens and antigen presenting machinery and, induction of positive immunomodulatory pathways. Here, we discuss potential mechanisms of radiation-induced enhancement of the anti-tumor response through its effect on the host immune system and explore potential combinational immune-based strategies such as adoptive cellular therapy using ex vivo expanded NK and T cells as a means of delivering a potent effector population in the context of radiation-enhanced anti-tumor immune environment.

Original languageEnglish
Pages (from-to)927-943
Number of pages17
JournalInternational journal of molecular sciences
Volume15
Issue number1
DOIs
Publication statusPublished - 2014 Jan 10

Keywords

  • Abscopal effect
  • Cell therapy
  • Radiation
  • Recognition
  • Trafficking

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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