The effects of Chamaecyparis obtusa essential oil on pain-related behavior and expression of pro-inflammatory cytokines in carrageenan-induced arthritis in rats

Hye Rim Suh, Hyun Joo Chung, Eui Ho Park, Sun Wook Moon, Su Jin Park, Chan Woo Park, Yang In Kim, Hee Chul Han

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chamaecyparis obtusa essential oil (COE) has been widely used to treat allergic diseases and was suggested to exert anti-inflammatory, antioxidant, and antimicrobial effects. This study evaluated the effects of COE on pain-related behavior and pro-inflammatory cytokines in rats with carrageenan (CGN)-induced arthritis. Reduced dynamic weight load on inflamed joint in voluntarily walking rats was used as the behavior test for arthritic pain; 10% COE-treated group was significantly attenuated pain (6-8 h post-CGN injection) compared to VEH (mineral oil)-treated group. In addition, the protein levels of interleukin (IL)-1β, tumor necrosis factor-α, IL-6 (6-8 h), and cyclooxygenase (COX)-2 (8 h) within the synovial membrane, as well as IL- 1β, COX-2 (6-8 h), and IL-6 (5-7 h) within the meniscus, of 10% COE-treated group were significantly reduced. The current results implicate that COE has anti-inflammatory and anti-nociceptive effects on arthritis in rats.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Volume80
Issue number1
DOIs
Publication statusPublished - 2016

Fingerprint

Chamaecyparis
Carrageenan
Volatile Oils
Arthritis
Rats
Cytokines
Pain
Cyclooxygenase 2
Interleukin-1
Interleukin-6
Anti-Inflammatory Agents
Mineral Oil
Synovial Membrane
Interleukin-5
Walking
Tumor Necrosis Factor-alpha
Antioxidants
Joints
Membranes
Weights and Measures

Keywords

  • Carrageenan-induced arthritis
  • Chamaecyparis obtusa essential oil
  • Dynamic weight load
  • Pro-inflammatory cytokines

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

The effects of Chamaecyparis obtusa essential oil on pain-related behavior and expression of pro-inflammatory cytokines in carrageenan-induced arthritis in rats. / Suh, Hye Rim; Chung, Hyun Joo; Park, Eui Ho; Moon, Sun Wook; Park, Su Jin; Park, Chan Woo; Kim, Yang In; Han, Hee Chul.

In: Bioscience, Biotechnology and Biochemistry, Vol. 80, No. 1, 2016, p. 203-209.

Research output: Contribution to journalArticle

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