The effects of high dose rate brachytherapy in recurrent obstructive bronchogenic cancer after external irradiation therapy

Youn Cho Jae Youn Cho, Ho In Kwang Ho In, Kyung Suh Jung Kyung Suh, Yong Kang Sea Yong Kang, Jeong Shim Jae Jeong Shim, Ho Kang Kyung Ho Kang, Hwa Yoo Se Hwa Yoo, Taek Kim Kwang Taek Kim, Yong Kim Cheol Yong Kim

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    1 Citation (Scopus)

    Abstract

    Background: Patients with centrally recurred bronchogenic carcinoma make a complaint of many symptoms like hemoptysis, cough and dyspnea. At these conditions, the goal of treatment is only to relieve their symptoms. High dose rate brachytherapy (HDR-BT) is the palliative treatment modality of centrally located endobronchial tumor regardless of previous external irradiation (XRT) on the same site in symptomatic patients. Methods: We studied the effects of HDR-BT in 26 patients with symptomatic recurrent lung cancer. Patients (male: 24, mean age: 54 yrs) were treated with HDR-BT underwent bronchoscopic placement of 192Ir HDR after loading unit (Gammamed®, Germany) to deliver 500cGY intraluminal irradiation at a depth of 1cm every 1wk on 3 occasions. Evaluation at base line and 4wks after HDR brachytherapy included chest X-ray, bronchoscopy, symptoms (Standardized Scale for dyspnea cough, hemoptysis), and Karnofsky performance Results: Endobronchial obstruction was improved in 11/26 patients (37%). A telectasis in chest X-ray was improved in 5/15 patients (33%). Hemoptysia, dyspnea and cough were improved in 5/10 patients (50%), 5/8 patients (62%) and 10/18 patients (56%) respectively. Karnofsky performance status was changed from 76.4 scores in pretreatment to 77.6 scores after treatment. During HDR-BT, massive hemoptysis (2 patients) and pneumothorax(1 patient) were occurred as complications. Conclusion: We concluded that HDR-BT gave additional benefits for the control of symptoms and general performance and endobronchial obstruction and atelectasis. And HDR-BT will be an additional treatment for the recurrent and endobronchial obstructive lung cancer.

    Original languageEnglish
    Pages (from-to)68-76
    Number of pages9
    JournalTuberculosis and Respiratory Diseases
    Volume45
    Issue number1
    DOIs
    Publication statusPublished - 1998

    Keywords

    • Bronchogenic Carcinoma
    • High dose rate brachytherapy

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine
    • Infectious Diseases

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