The effects of midazolam on the bispectral index after fetal expulsion in caesarean section under general anaesthesia with sevoflurane

S. J. Ok, Woon Young Kim, Yoon Sook Lee, K. G. Kim, Hye Won Shin, M. S. Chang, Jae Hwan Kim, Young Cheol Park

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3 Citations (Scopus)


The effects of midazolam used with low concentration inhaled anaesthetics on the bispectral index (BIS) was investigated after fetal expulsion during caesarean section. Forty-five patients undergoing caesarean section received either normal saline (control, n = 15), or an intravenous bolus of 0.03 mg/kg (n = 15) or 0.05 mg/kg (n = 15) midazolam. Changes in BIS and maternal haemodynamics were monitored before induction, on intubation, at uterine incision, on delivery, at 3, 5 and 10 min after fetal expulsion, at subcutaneous tissue closure, at skin closure, on eye opening and at extubation. BIS values in the group that received 0.05 mg/kg midazolam were significantly lower than in the other two groups at 3, 5 and 10 min after fetal expulsion, and at subcutaneous tissue closure and skin closure. Values of BIS < 60 could only be maintained with 0.05 mg/kg midazolam and there was no delay in maternal emergence or recovery.

Original languageEnglish
Pages (from-to)154-162
Number of pages9
JournalJournal of International Medical Research
Issue number1
Publication statusPublished - 2009 Jan 1



  • BIS
  • Bispectral index
  • Caesarean section
  • Fetal expulsion
  • Midazolam
  • Sevoflurane

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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