The effects of midazolam on the bispectral index after fetal expulsion in caesarean section under general anaesthesia with sevoflurane

S. J. Ok, Woon Young Kim, Y. S. Lee, K. G. Kim, H. W. Shin, M. S. Chang, J. H. Kim, Y. C. Park

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    The effects of midazolam used with low concentration inhaled anaesthetics on the bispectral index (BIS) was investigated after fetal expulsion during caesarean section. Forty-five patients undergoing caesarean section received either normal saline (control, n = 15), or an intravenous bolus of 0.03 mg/kg (n = 15) or 0.05 mg/kg (n = 15) midazolam. Changes in BIS and maternal haemodynamics were monitored before induction, on intubation, at uterine incision, on delivery, at 3, 5 and 10 min after fetal expulsion, at subcutaneous tissue closure, at skin closure, on eye opening and at extubation. BIS values in the group that received 0.05 mg/kg midazolam were significantly lower than in the other two groups at 3, 5 and 10 min after fetal expulsion, and at subcutaneous tissue closure and skin closure. Values of BIS < 60 could only be maintained with 0.05 mg/kg midazolam and there was no delay in maternal emergence or recovery.

    Original languageEnglish
    Pages (from-to)154-162
    Number of pages9
    JournalJournal of International Medical Research
    Volume37
    Issue number1
    DOIs
    Publication statusPublished - 2009

    Keywords

    • BIS
    • Bispectral index
    • Caesarean section
    • Fetal expulsion
    • Midazolam
    • Sevoflurane

    ASJC Scopus subject areas

    • Biochemistry
    • Cell Biology
    • Biochemistry, medical

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