TY - JOUR
T1 - The effects of milrinone on platelets in patients undergoing cardiac surgery
AU - Kikura, M.
AU - Lee, M. K.
AU - Safon, R. A.
AU - Bailey, J. M.
AU - Levy, J. H.
PY - 1995
Y1 - 1995
N2 - Although amrinone produces thrombocytopenia, no information is available regarding the acute effects of milrinone/in platelets. Therefore, we evaluated the effects of milrinone on platelet number and function in cardiac surgical patients. Twenty-seven patients were studied during cardiac surgery requiring cardiopulmonary bypass (CPB). Patients were randomized to receive no milrinone (n = 10), or milrinone (n = 17) at a loading dose of 50- 75/μg/kg in the CPB circuit followed by 0.5-0.75 μg · kg 1 · min-1 for 12-24 h. Bleeding times and blood samples for coagulation studies were obtained prior to induction, and at 2 and 24 h after CPB. In both groups, platelet counts decreased significantly from the baseline at 2 and 24 h after CPB, and bleeding time increased significantly from the baseline at 2 and 24 h after CPB. No significant thromboelastoplasty (TEG) changes were observed in either group, and there were no significant differences in platelet aggregation or chest tube drainage between the groups Acute milrinone administration did not cause significant changes in platelet number or function in patients undergoing cardiac operations requiring CPB, beyond the usual adverse effects of cardiac surgery and CPB.
AB - Although amrinone produces thrombocytopenia, no information is available regarding the acute effects of milrinone/in platelets. Therefore, we evaluated the effects of milrinone on platelet number and function in cardiac surgical patients. Twenty-seven patients were studied during cardiac surgery requiring cardiopulmonary bypass (CPB). Patients were randomized to receive no milrinone (n = 10), or milrinone (n = 17) at a loading dose of 50- 75/μg/kg in the CPB circuit followed by 0.5-0.75 μg · kg 1 · min-1 for 12-24 h. Bleeding times and blood samples for coagulation studies were obtained prior to induction, and at 2 and 24 h after CPB. In both groups, platelet counts decreased significantly from the baseline at 2 and 24 h after CPB, and bleeding time increased significantly from the baseline at 2 and 24 h after CPB. No significant thromboelastoplasty (TEG) changes were observed in either group, and there were no significant differences in platelet aggregation or chest tube drainage between the groups Acute milrinone administration did not cause significant changes in platelet number or function in patients undergoing cardiac operations requiring CPB, beyond the usual adverse effects of cardiac surgery and CPB.
UR - http://www.scopus.com/inward/record.url?scp=0029013798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029013798&partnerID=8YFLogxK
U2 - 10.1097/00000539-199507000-00009
DO - 10.1097/00000539-199507000-00009
M3 - Article
C2 - 7598280
AN - SCOPUS:0029013798
VL - 81
SP - 44
EP - 48
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
SN - 0003-2999
IS - 1
ER -