Abstract
Although amrinone produces thrombocytopenia, no information is available regarding the acute effects of milrinone/in platelets. Therefore, we evaluated the effects of milrinone on platelet number and function in cardiac surgical patients. Twenty-seven patients were studied during cardiac surgery requiring cardiopulmonary bypass (CPB). Patients were randomized to receive no milrinone (n = 10), or milrinone (n = 17) at a loading dose of 50- 75/μg/kg in the CPB circuit followed by 0.5-0.75 μg · kg 1 · min-1 for 12-24 h. Bleeding times and blood samples for coagulation studies were obtained prior to induction, and at 2 and 24 h after CPB. In both groups, platelet counts decreased significantly from the baseline at 2 and 24 h after CPB, and bleeding time increased significantly from the baseline at 2 and 24 h after CPB. No significant thromboelastoplasty (TEG) changes were observed in either group, and there were no significant differences in platelet aggregation or chest tube drainage between the groups Acute milrinone administration did not cause significant changes in platelet number or function in patients undergoing cardiac operations requiring CPB, beyond the usual adverse effects of cardiac surgery and CPB.
| Original language | English |
|---|---|
| Pages (from-to) | 44-48 |
| Number of pages | 5 |
| Journal | Anesthesia and Analgesia |
| Volume | 81 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1995 Jul 11 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
The effects of milrinone on platelets in patients undergoing cardiac surgery. / Kikura, M.; Lee, Mi Kyoung; Safon, R. A.; Bailey, J. M.; Levy, J. H.
In: Anesthesia and Analgesia, Vol. 81, No. 1, 11.07.1995, p. 44-48.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of milrinone on platelets in patients undergoing cardiac surgery
AU - Kikura, M.
AU - Lee, Mi Kyoung
AU - Safon, R. A.
AU - Bailey, J. M.
AU - Levy, J. H.
PY - 1995/7/11
Y1 - 1995/7/11
N2 - Although amrinone produces thrombocytopenia, no information is available regarding the acute effects of milrinone/in platelets. Therefore, we evaluated the effects of milrinone on platelet number and function in cardiac surgical patients. Twenty-seven patients were studied during cardiac surgery requiring cardiopulmonary bypass (CPB). Patients were randomized to receive no milrinone (n = 10), or milrinone (n = 17) at a loading dose of 50- 75/μg/kg in the CPB circuit followed by 0.5-0.75 μg · kg 1 · min-1 for 12-24 h. Bleeding times and blood samples for coagulation studies were obtained prior to induction, and at 2 and 24 h after CPB. In both groups, platelet counts decreased significantly from the baseline at 2 and 24 h after CPB, and bleeding time increased significantly from the baseline at 2 and 24 h after CPB. No significant thromboelastoplasty (TEG) changes were observed in either group, and there were no significant differences in platelet aggregation or chest tube drainage between the groups Acute milrinone administration did not cause significant changes in platelet number or function in patients undergoing cardiac operations requiring CPB, beyond the usual adverse effects of cardiac surgery and CPB.
AB - Although amrinone produces thrombocytopenia, no information is available regarding the acute effects of milrinone/in platelets. Therefore, we evaluated the effects of milrinone on platelet number and function in cardiac surgical patients. Twenty-seven patients were studied during cardiac surgery requiring cardiopulmonary bypass (CPB). Patients were randomized to receive no milrinone (n = 10), or milrinone (n = 17) at a loading dose of 50- 75/μg/kg in the CPB circuit followed by 0.5-0.75 μg · kg 1 · min-1 for 12-24 h. Bleeding times and blood samples for coagulation studies were obtained prior to induction, and at 2 and 24 h after CPB. In both groups, platelet counts decreased significantly from the baseline at 2 and 24 h after CPB, and bleeding time increased significantly from the baseline at 2 and 24 h after CPB. No significant thromboelastoplasty (TEG) changes were observed in either group, and there were no significant differences in platelet aggregation or chest tube drainage between the groups Acute milrinone administration did not cause significant changes in platelet number or function in patients undergoing cardiac operations requiring CPB, beyond the usual adverse effects of cardiac surgery and CPB.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029013798&partnerID=8YFLogxK
U2 - 10.1097/00000539-199507000-00009
DO - 10.1097/00000539-199507000-00009
M3 - Article
C2 - 7598280
AN - SCOPUS:0029013798
VL - 81
SP - 44
EP - 48
JO - Current researches in anesthesia & analgesia
JF - Current researches in anesthesia & analgesia
SN - 0003-2999
IS - 1
ER -