The effects of photodynamic therapy in upper-gastrointestinal malignant diseases

Key Hyeon Kim, Jong Jae Park

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) is a promising new modality that utilizes the combination of a photosensitizing chemical and visible light for the management of various solid malignancies, including gastrointestinal (GI) cancer. PDT has some advantages over chemotherapy in terms of its greater safety and lower toxicity in the treatment of malignant lesions. However, PDT has not been used widely for treating upper GI cancer due to its relatively low cost-effectiveness and anatomical characteristics of the GI system. Nevertheless, PDT may be an effective alternative therapy for early upper-GI cancer patients who are at a high risk of curative surgical resection or systemic chemotherapy. In some clinical studies, PDT for various upper GI cancer showed positiveresults. To improve the efficacy of PDT for upper GI cancer, development of photosensitezer and light delivery system is needed.

Original languageEnglish
JournalGut and Liver
Volume4
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2010 Sep 1

Fingerprint

Gastrointestinal Diseases
Photochemotherapy
Gastrointestinal Neoplasms
Light
Drug Therapy
Complementary Therapies
Cost-Benefit Analysis
Safety
Neoplasms

Keywords

  • Photodynamic therapy
  • Photosensitizer
  • Upper-gastrointestinal cancer

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

The effects of photodynamic therapy in upper-gastrointestinal malignant diseases. / Kim, Key Hyeon; Park, Jong Jae.

In: Gut and Liver, Vol. 4, No. SUPPL. 1, 01.09.2010.

Research output: Contribution to journalReview article

@article{5920cab0cab743d79685b85981acc32a,
title = "The effects of photodynamic therapy in upper-gastrointestinal malignant diseases",
abstract = "Photodynamic therapy (PDT) is a promising new modality that utilizes the combination of a photosensitizing chemical and visible light for the management of various solid malignancies, including gastrointestinal (GI) cancer. PDT has some advantages over chemotherapy in terms of its greater safety and lower toxicity in the treatment of malignant lesions. However, PDT has not been used widely for treating upper GI cancer due to its relatively low cost-effectiveness and anatomical characteristics of the GI system. Nevertheless, PDT may be an effective alternative therapy for early upper-GI cancer patients who are at a high risk of curative surgical resection or systemic chemotherapy. In some clinical studies, PDT for various upper GI cancer showed positiveresults. To improve the efficacy of PDT for upper GI cancer, development of photosensitezer and light delivery system is needed.",
keywords = "Photodynamic therapy, Photosensitizer, Upper-gastrointestinal cancer",
author = "Kim, {Key Hyeon} and Park, {Jong Jae}",
year = "2010",
month = "9",
day = "1",
doi = "10.5009/gnl.2010.4.S1.S39",
language = "English",
volume = "4",
journal = "Gut and Liver",
issn = "1976-2283",
publisher = "Joe Bok Chung",
number = "SUPPL. 1",

}

TY - JOUR

T1 - The effects of photodynamic therapy in upper-gastrointestinal malignant diseases

AU - Kim, Key Hyeon

AU - Park, Jong Jae

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Photodynamic therapy (PDT) is a promising new modality that utilizes the combination of a photosensitizing chemical and visible light for the management of various solid malignancies, including gastrointestinal (GI) cancer. PDT has some advantages over chemotherapy in terms of its greater safety and lower toxicity in the treatment of malignant lesions. However, PDT has not been used widely for treating upper GI cancer due to its relatively low cost-effectiveness and anatomical characteristics of the GI system. Nevertheless, PDT may be an effective alternative therapy for early upper-GI cancer patients who are at a high risk of curative surgical resection or systemic chemotherapy. In some clinical studies, PDT for various upper GI cancer showed positiveresults. To improve the efficacy of PDT for upper GI cancer, development of photosensitezer and light delivery system is needed.

AB - Photodynamic therapy (PDT) is a promising new modality that utilizes the combination of a photosensitizing chemical and visible light for the management of various solid malignancies, including gastrointestinal (GI) cancer. PDT has some advantages over chemotherapy in terms of its greater safety and lower toxicity in the treatment of malignant lesions. However, PDT has not been used widely for treating upper GI cancer due to its relatively low cost-effectiveness and anatomical characteristics of the GI system. Nevertheless, PDT may be an effective alternative therapy for early upper-GI cancer patients who are at a high risk of curative surgical resection or systemic chemotherapy. In some clinical studies, PDT for various upper GI cancer showed positiveresults. To improve the efficacy of PDT for upper GI cancer, development of photosensitezer and light delivery system is needed.

KW - Photodynamic therapy

KW - Photosensitizer

KW - Upper-gastrointestinal cancer

UR - http://www.scopus.com/inward/record.url?scp=77957597557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957597557&partnerID=8YFLogxK

U2 - 10.5009/gnl.2010.4.S1.S39

DO - 10.5009/gnl.2010.4.S1.S39

M3 - Review article

VL - 4

JO - Gut and Liver

JF - Gut and Liver

SN - 1976-2283

IS - SUPPL. 1

ER -