The effects of pulsatile flow upon renal tissue perfusion during cardiopulmonary bypass: A comparative study of pulsatile and nonpulsatile flow

Hyun Koo Kim, Ho Sung Son, Hu Fang Yong, Young Park Sung, Mo Hwang Chang, Kyung Sun

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

This study was conducted to directly compare the effects of pulsatile and nonpulsatile blood flow in the extracorporeal circulation upon renal tissue perfusion by using a tissue perfusion measurement system. A total cardiopulmonary bypass circuit was constructed to accommodate twelve Yorkshire swine, weighing 20-30 kg. Animals were randomly assigned to group 1 (n = 6, nonpulsatile centrifugal pump) or group 2 (n = 6, pulsatile T-PLS pump). A tissue perfusion measurement probe (Q-Flow 500) was inserted into the renal parenchymal tissue, and the extracorporeal circulation was maintained for an hour at a pump flow rate of 2 L/min after aortic cross-clamping. Tissue perfusion flow in the kidney was measured before bypass and every 10 minutes after bypass. Renal tissue perfusion flow was substantially higher in the pulsatile group throughout bypass (ranging 48.5-64.1 ml/min/100 g in group 1 vs. 51.0-88.1 ml/min/100 g in group 2). The intergroup difference was significant at 30 minutes (47.5 ± 18.3 ml/min/100 g in group 1 vs. 83.4 ± 28.5 ml/min/100 g in group 2; p = 0.026). Pulsatile flow achieves higher levels of tissue perfusion of the kidney during short-term extracorporeal circulation. A further study is required to observe the effects of pulsatile flow upon other vital organs and its long-term significance.

Original languageEnglish
Pages (from-to)30-36
Number of pages7
JournalASAIO Journal
Volume51
Issue number1
DOIs
Publication statusPublished - 2005 Jan 1

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Pulsatile Flow
Pulsatile flow
Cardiopulmonary Bypass
Perfusion
Tissue
Kidney
Extracorporeal Circulation
Pumps
Constriction
Centrifugal pumps
Weighing
Swine
Animals
Blood
Flow rate
Networks (circuits)

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

The effects of pulsatile flow upon renal tissue perfusion during cardiopulmonary bypass : A comparative study of pulsatile and nonpulsatile flow. / Kim, Hyun Koo ; Son, Ho Sung; Yong, Hu Fang; Sung, Young Park; Chang, Mo Hwang; Sun, Kyung.

In: ASAIO Journal, Vol. 51, No. 1, 01.01.2005, p. 30-36.

Research output: Contribution to journalArticle

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