The Effects of Single Nucleotide Polymorphisms in Korean Patients with Early-onset Atrial Fibrillation after Catheter Ablation

Yae Min Park, Seung Young Roh, Dae In Lee, Jaemin Shim, Jong Il Choi, Sang Weon Park, Young Hoon Kim

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: This study evaluated the status of single nucleotide polymorphisms (SNPs) in Korean patients with early-onset (< 40 years old) atrial fibrillation (AF) and their effects on the outcome after catheter ablation. Methods: A total of 89 patients (35.7 ± 3.7 years, 81 males) with drug-refractory AF (paroxysmal 64.0%) who underwent catheter ablation were included in this study. Sixteen SNPs, including rs13376333, rs10465885, rs10033464, rs2200733, rs17042171, rs6843082, rs7193343, rs2106261, rs17570669, rs853445, rs11708996, rs6800541, rs251253, rs3807989, rs11047543, and rs3825214, were genotyped. Serial 48-hour Holter monitoring was conducted to detect AF recurrences during long-term follow up. Results: Wild-type genotypes of rs11047543 (GG; 26/69 [37.7%] vs. GA; 13/18 [72.2%] vs. AA; 0/0 [0%], P= 0.009) and rs7193343 (CC; 0/7 [0%] vs. CT; 22/40 [55.0%] vs. TT; 18/41 [43.9%], P= 0.025) and the homozygous variant of rs3825214 (AA; 16/31 [51.6%] vs. AG; 22/43 [51.2%] vs. GG; 2/13 [15.4%], P= 0.056) were significantly associated with a lower rate of late recurrence. When the patients were assigned to four groups according to the number of risk alleles (n = 0–3), there were significant differences in recurrence rate (n = 0; 0/3 vs. n = 1; 2/13 [15.4%] vs. n = 2; 24/52 [46.2%] vs. n = 3; 13/17 [76.5%], P= 0.003). When correcting for multiple variables, rs11047543 (hazard ratio [HR], 2.723; 95% confidence interval [CI], 1.358–5.461; P= 0.005) and the number of risk alleles (HR, 2.901; 95% CI, 1.612–5.219; P< 0.001) were significantly associated with recurrence of AF after catheter ablation. Conclusion: Polymorphisms on rs7193343 closest to ZFHX3 (16q22), rs3825214 near to TBX5 (12q24), and rs11047543 near to SOX5 (12p12) modulate the risk for AF recurrence after catheter ablation and the number of risk alleles of these 3 SNPs was independent predictor of recurrence during long-term follow up in Korean patients with early-onset AF.

    Original languageEnglish
    Pages (from-to)1-13
    Number of pages13
    JournalJournal of Korean medical science
    Volume35
    Issue number49
    DOIs
    Publication statusPublished - 2020

    Keywords

    • Atrial Fibrillation (AF)
    • Catheter Ablation
    • Single Nucleotide Polymorphisms (SNPs)

    ASJC Scopus subject areas

    • Medicine(all)

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