The efficacy of added montelukast in persistent asthmatics who were not completely controlled on inhaled corticosteroids and inhaled long-acting β2-agonists

Jeong Hee Choi, Hae Sim Park, Kwan Ho Lee, Jae Jeong Shim, Soo Taek Uh, Sang Pyo Lee, Yong Chul Lee, Won Il Choi, Joo In Kim, Jae Ho Lee, Myung Goo Lee, Ki Suck Jung

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Backgrounds: Although glucocorticoids are one of the most potent anti-inflammatory agents, they have limited effect on cysteinyl leukotriene biosynthesis. In addition, the response to inhaled corticosteroids (ICS) and inhaled long-acting β2-agonists (LABA) combination therapy in moderate to severe persistent asthmatics varies. Additional therapy with leukotriene receptor antagonists (LTRA) in patients with moderate to severe asthma suboptimally controlled with ICS and LABA combination therapy would be complementary to asthma control. Methods: One hundred and ninety eight asthmatics entered a 2 month, open-label descriptive study. Patients suffering from persistent asthma and suboptimally controlled on a combination therapy of fluticasone/salmeterol or budesonide/formoterol were given montelukast 10 mg daily as an add-on therapy. The level of asthma control was assessed using the Asthma Control Questionnaire (ACQ) including FEV1 % predicted at the baseline and after a 2-month treatment with montelukast. A global evaluation of the treatment was also made by the patients and physicians. Results: The mean ACQ score decreased significantly on montelukast (11.5±5.4 at baseline vs. 6.7±5.0), with a significant improvement in all individual symptom scores (p<0.01). The FEV1 % predicted values did not show any significant change. 59.9% of patients and 59.4% of physicians reported global improvement in their asthma (κ=0.85). Conclusion: These results suggest that the addition of montelukast in patients with persistent asthma that is suboptimally contolled by combination therapy of ICS and LABA might confer complementary effects on asthma control.

    Original languageEnglish
    Pages (from-to)337-345
    Number of pages9
    JournalTuberculosis and Respiratory Diseases
    Volume63
    Issue number4
    DOIs
    Publication statusPublished - 2007 Oct

    Keywords

    • Asthma control
    • Inhaled glucocorticosteroid
    • Long-acting inhaled β2-agonist
    • Montelukast

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine
    • Infectious Diseases

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