The Efficacy of Bone Morphogenetic Protein-2 Depends on Its Mode of Delivery

Wan Geun La, Sun Woong Kang, Hee Seok Yang, Suk Ho Bhang, Sun Hwa Lee, Jung Ho Park, Byung Soo Kim

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)


Bone morphogenetic protein-2 (BMP-2) induces bone regeneration in a dose-dependent manner, with higher doses of BMP-2 inducing greater bone formation. Previously, we showed that long-term delivery of BMP-2 provides better ectopic bone formation than short-term delivery of an equivalent dose. In the present study, we investigated the efficacy of orthotopic bone formation over a range of BMP-2 doses, using different delivery modes. Heparin-conjugated poly(lactic-co-glycolic acid) nanospheres suspended in fibrin gel were used as a long-term delivery system, and fibrin gel was used as a short-term delivery system. Different doses of BMP-2 were delivered to mouse calvarial defects using either long-term or short-term delivery systems. Eight weeks after treatment, bone regeneration was evaluated by histomorphometry. For both delivery systems, bone regeneration increased as the BMP-2 dose increased up to 1 μg and did not increase beyond this dose. Importantly, at BMP-2 doses higher than 1 μg, long-term delivery resulted in much greater bone formation than short-term delivery. This study shows that long-term delivery of BMP-2 is more effective at enhancing orthotopic bone formation than short-term delivery over a range of doses.

Original languageEnglish
Pages (from-to)1150-1153
Number of pages4
JournalArtificial Organs
Issue number12
Publication statusPublished - 2010 Dec
Externally publishedYes


  • BMP-2 delivery
  • Bone formation
  • Fibrin gel
  • Heparin-conjugated poly(lactic-co-glycolic acid) nanosphere

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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