The Efficacy of Bone Morphogenetic Protein-2 Depends on Its Mode of Delivery

Wan Geun La, Sun Woong Kang, Hee Seok Yang, Suk Ho Bhang, Sun Hwa Lee, Jung-Ho Park, Byung Soo Kim

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Bone morphogenetic protein-2 (BMP-2) induces bone regeneration in a dose-dependent manner, with higher doses of BMP-2 inducing greater bone formation. Previously, we showed that long-term delivery of BMP-2 provides better ectopic bone formation than short-term delivery of an equivalent dose. In the present study, we investigated the efficacy of orthotopic bone formation over a range of BMP-2 doses, using different delivery modes. Heparin-conjugated poly(lactic-co-glycolic acid) nanospheres suspended in fibrin gel were used as a long-term delivery system, and fibrin gel was used as a short-term delivery system. Different doses of BMP-2 were delivered to mouse calvarial defects using either long-term or short-term delivery systems. Eight weeks after treatment, bone regeneration was evaluated by histomorphometry. For both delivery systems, bone regeneration increased as the BMP-2 dose increased up to 1 μg and did not increase beyond this dose. Importantly, at BMP-2 doses higher than 1 μg, long-term delivery resulted in much greater bone formation than short-term delivery. This study shows that long-term delivery of BMP-2 is more effective at enhancing orthotopic bone formation than short-term delivery over a range of doses.

Original languageEnglish
Pages (from-to)1150-1153
Number of pages4
JournalArtificial Organs
Volume34
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

Keywords

  • BMP-2 delivery
  • Bone formation
  • Fibrin gel
  • Heparin-conjugated poly(lactic-co-glycolic acid) nanosphere

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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  • Cite this

    La, W. G., Kang, S. W., Yang, H. S., Bhang, S. H., Lee, S. H., Park, J-H., & Kim, B. S. (2010). The Efficacy of Bone Morphogenetic Protein-2 Depends on Its Mode of Delivery. Artificial Organs, 34(12), 1150-1153. https://doi.org/10.1111/j.1525-1594.2009.00988.x