Abstract
Background: There are many collagen-stimulating fillers, including calcium hydroxyapatite, polycaprolactone (PCL), and poly-L-lactic acid (PLLA), and other materials have been tested. Polydioxanone (PDO) has recently been used as absorbable thread-lifting material due to its collagen-forming effects. PDO in powdered form is expected to be a good material for collagen-producing fillers. Objectives: To evaluate the collagen-producing effects of powdered PDO injection compared with PLLA injection in a murine model. Materials and Methods: Powdered PDO mixed with sodium carboxymethyl cellulose, PLLA, and phosphate-buffered saline was injected on dorsal skin of 8-week-old rat. Tissue samples were obtained 1, 2, and 12 weeks after the procedures for histopathologic review and for real-time PCR to quantify collagen and tissue growth factors. Results: Both PLLA and powdered PDO injections induced granulomatous reactions. Collagen type 1, collagen type 3, TGF-β1, TGF-β2, and TGF-β3 showed increases 2 weeks after injection but decreased 12 weeks after injection for both powdered PDO and PLLA. Conclusion: Our results suggested that powdered PDO injection induces collagen formation more effectively than PLLA injection. Therefore, PDO can be a good option for forming collagen.
| Original language | English |
|---|---|
| Journal | Journal of Cosmetic Dermatology |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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Keywords
- collagen
- poly-L-lactic acid
- polydioxanone
ASJC Scopus subject areas
- Dermatology
Cite this
The efficacy of powdered polydioxanone in terms of collagen production compared with poly-L-lactic acid in a murine model. / Kim, Chang Min; Kim, Bo Young; Hye Suh, Dong; Lee, Sang Jun; Moon, Hye Rim; Ryu, Hwa Jung.
In: Journal of Cosmetic Dermatology, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The efficacy of powdered polydioxanone in terms of collagen production compared with poly-L-lactic acid in a murine model
AU - Kim, Chang Min
AU - Kim, Bo Young
AU - Hye Suh, Dong
AU - Lee, Sang Jun
AU - Moon, Hye Rim
AU - Ryu, Hwa Jung
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: There are many collagen-stimulating fillers, including calcium hydroxyapatite, polycaprolactone (PCL), and poly-L-lactic acid (PLLA), and other materials have been tested. Polydioxanone (PDO) has recently been used as absorbable thread-lifting material due to its collagen-forming effects. PDO in powdered form is expected to be a good material for collagen-producing fillers. Objectives: To evaluate the collagen-producing effects of powdered PDO injection compared with PLLA injection in a murine model. Materials and Methods: Powdered PDO mixed with sodium carboxymethyl cellulose, PLLA, and phosphate-buffered saline was injected on dorsal skin of 8-week-old rat. Tissue samples were obtained 1, 2, and 12 weeks after the procedures for histopathologic review and for real-time PCR to quantify collagen and tissue growth factors. Results: Both PLLA and powdered PDO injections induced granulomatous reactions. Collagen type 1, collagen type 3, TGF-β1, TGF-β2, and TGF-β3 showed increases 2 weeks after injection but decreased 12 weeks after injection for both powdered PDO and PLLA. Conclusion: Our results suggested that powdered PDO injection induces collagen formation more effectively than PLLA injection. Therefore, PDO can be a good option for forming collagen.
AB - Background: There are many collagen-stimulating fillers, including calcium hydroxyapatite, polycaprolactone (PCL), and poly-L-lactic acid (PLLA), and other materials have been tested. Polydioxanone (PDO) has recently been used as absorbable thread-lifting material due to its collagen-forming effects. PDO in powdered form is expected to be a good material for collagen-producing fillers. Objectives: To evaluate the collagen-producing effects of powdered PDO injection compared with PLLA injection in a murine model. Materials and Methods: Powdered PDO mixed with sodium carboxymethyl cellulose, PLLA, and phosphate-buffered saline was injected on dorsal skin of 8-week-old rat. Tissue samples were obtained 1, 2, and 12 weeks after the procedures for histopathologic review and for real-time PCR to quantify collagen and tissue growth factors. Results: Both PLLA and powdered PDO injections induced granulomatous reactions. Collagen type 1, collagen type 3, TGF-β1, TGF-β2, and TGF-β3 showed increases 2 weeks after injection but decreased 12 weeks after injection for both powdered PDO and PLLA. Conclusion: Our results suggested that powdered PDO injection induces collagen formation more effectively than PLLA injection. Therefore, PDO can be a good option for forming collagen.
KW - collagen
KW - poly-L-lactic acid
KW - polydioxanone
UR - http://www.scopus.com/inward/record.url?scp=85062321418&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062321418&partnerID=8YFLogxK
U2 - 10.1111/jocd.12894
DO - 10.1111/jocd.12894
M3 - Article
C2 - 30809959
AN - SCOPUS:85062321418
JO - Journal of Cosmetic Dermatology
JF - Journal of Cosmetic Dermatology
SN - 1473-2130
ER -