The electron beam deposition of titanium on polyetheretherketone (PEEK) and the resulting enhanced biological properties

Cheol Min Han, Eun Jung Lee, Hyoun Ee Kim, Young-Hag Koh, Keung N. Kim, Yoon Ha, Sung Uk Kuh

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

The surface of polyetheretherketone (PEEK) was coated with a pure titanium (Ti) layer using an electron beam (e-beam) deposition method in order to enhance its biocompatibility and adhesion to bone tissue. The e-beam deposition method was a low-temperature coating process that formed a dense, uniform and well crystallized Ti layer without deteriorating the characteristics of the PEEK implant. The Ti coating layer strongly adhered to the substrate and remarkably enhanced its wettability. The Ti-coated samples were evaluated in terms of their in vitro cellular behaviors and in vivo osteointegration, and the results were compared to a pure PEEK substrate. The level of proliferation of the cells (MC3T3-E1) was measured using a methoxyphenyl tetrazolium salt (MTS) assay and more than doubled after the Ti coating. The differentiation level of cells was measured using the alkaline phosphatase (ALP) assay and also doubled. Furthermore, the in vivo animal tests showed that the Ti-coated PEEK implants had a much higher bone-in-contact (BIC) ratio than the pure PEEK implants. These in vitro and in vivo results suggested that the e-beam deposited Ti coating significantly improved the potential of PEEK for hard tissue applications.

Original languageEnglish
Pages (from-to)3465-3470
Number of pages6
JournalBiomaterials
Volume31
Issue number13
DOIs
Publication statusPublished - 2010 May 1

Fingerprint

Titanium
Electron beams
Electrons
Coatings
Assays
Bone
Tetrazolium Salts
Tissue
Wettability
Bone and Bones
Phosphatases
Substrates
polyetheretherketone
Biocompatibility
Alkaline Phosphatase
Wetting
Cell Differentiation
Animals
Adhesion
Cell Proliferation

Keywords

  • Biocompatibility
  • e-beam
  • Polyetheretherketone (PEEK)
  • Ti coating

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

Cite this

The electron beam deposition of titanium on polyetheretherketone (PEEK) and the resulting enhanced biological properties. / Han, Cheol Min; Lee, Eun Jung; Kim, Hyoun Ee; Koh, Young-Hag; Kim, Keung N.; Ha, Yoon; Kuh, Sung Uk.

In: Biomaterials, Vol. 31, No. 13, 01.05.2010, p. 3465-3470.

Research output: Contribution to journalArticle

Han, Cheol Min ; Lee, Eun Jung ; Kim, Hyoun Ee ; Koh, Young-Hag ; Kim, Keung N. ; Ha, Yoon ; Kuh, Sung Uk. / The electron beam deposition of titanium on polyetheretherketone (PEEK) and the resulting enhanced biological properties. In: Biomaterials. 2010 ; Vol. 31, No. 13. pp. 3465-3470.
@article{468f3ed233114ed4a123a2ecb8ebe56b,
title = "The electron beam deposition of titanium on polyetheretherketone (PEEK) and the resulting enhanced biological properties",
abstract = "The surface of polyetheretherketone (PEEK) was coated with a pure titanium (Ti) layer using an electron beam (e-beam) deposition method in order to enhance its biocompatibility and adhesion to bone tissue. The e-beam deposition method was a low-temperature coating process that formed a dense, uniform and well crystallized Ti layer without deteriorating the characteristics of the PEEK implant. The Ti coating layer strongly adhered to the substrate and remarkably enhanced its wettability. The Ti-coated samples were evaluated in terms of their in vitro cellular behaviors and in vivo osteointegration, and the results were compared to a pure PEEK substrate. The level of proliferation of the cells (MC3T3-E1) was measured using a methoxyphenyl tetrazolium salt (MTS) assay and more than doubled after the Ti coating. The differentiation level of cells was measured using the alkaline phosphatase (ALP) assay and also doubled. Furthermore, the in vivo animal tests showed that the Ti-coated PEEK implants had a much higher bone-in-contact (BIC) ratio than the pure PEEK implants. These in vitro and in vivo results suggested that the e-beam deposited Ti coating significantly improved the potential of PEEK for hard tissue applications.",
keywords = "Biocompatibility, e-beam, Polyetheretherketone (PEEK), Ti coating",
author = "Han, {Cheol Min} and Lee, {Eun Jung} and Kim, {Hyoun Ee} and Young-Hag Koh and Kim, {Keung N.} and Yoon Ha and Kuh, {Sung Uk}",
year = "2010",
month = "5",
day = "1",
doi = "10.1016/j.biomaterials.2009.12.030",
language = "English",
volume = "31",
pages = "3465--3470",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier BV",
number = "13",

}

TY - JOUR

T1 - The electron beam deposition of titanium on polyetheretherketone (PEEK) and the resulting enhanced biological properties

AU - Han, Cheol Min

AU - Lee, Eun Jung

AU - Kim, Hyoun Ee

AU - Koh, Young-Hag

AU - Kim, Keung N.

AU - Ha, Yoon

AU - Kuh, Sung Uk

PY - 2010/5/1

Y1 - 2010/5/1

N2 - The surface of polyetheretherketone (PEEK) was coated with a pure titanium (Ti) layer using an electron beam (e-beam) deposition method in order to enhance its biocompatibility and adhesion to bone tissue. The e-beam deposition method was a low-temperature coating process that formed a dense, uniform and well crystallized Ti layer without deteriorating the characteristics of the PEEK implant. The Ti coating layer strongly adhered to the substrate and remarkably enhanced its wettability. The Ti-coated samples were evaluated in terms of their in vitro cellular behaviors and in vivo osteointegration, and the results were compared to a pure PEEK substrate. The level of proliferation of the cells (MC3T3-E1) was measured using a methoxyphenyl tetrazolium salt (MTS) assay and more than doubled after the Ti coating. The differentiation level of cells was measured using the alkaline phosphatase (ALP) assay and also doubled. Furthermore, the in vivo animal tests showed that the Ti-coated PEEK implants had a much higher bone-in-contact (BIC) ratio than the pure PEEK implants. These in vitro and in vivo results suggested that the e-beam deposited Ti coating significantly improved the potential of PEEK for hard tissue applications.

AB - The surface of polyetheretherketone (PEEK) was coated with a pure titanium (Ti) layer using an electron beam (e-beam) deposition method in order to enhance its biocompatibility and adhesion to bone tissue. The e-beam deposition method was a low-temperature coating process that formed a dense, uniform and well crystallized Ti layer without deteriorating the characteristics of the PEEK implant. The Ti coating layer strongly adhered to the substrate and remarkably enhanced its wettability. The Ti-coated samples were evaluated in terms of their in vitro cellular behaviors and in vivo osteointegration, and the results were compared to a pure PEEK substrate. The level of proliferation of the cells (MC3T3-E1) was measured using a methoxyphenyl tetrazolium salt (MTS) assay and more than doubled after the Ti coating. The differentiation level of cells was measured using the alkaline phosphatase (ALP) assay and also doubled. Furthermore, the in vivo animal tests showed that the Ti-coated PEEK implants had a much higher bone-in-contact (BIC) ratio than the pure PEEK implants. These in vitro and in vivo results suggested that the e-beam deposited Ti coating significantly improved the potential of PEEK for hard tissue applications.

KW - Biocompatibility

KW - e-beam

KW - Polyetheretherketone (PEEK)

KW - Ti coating

UR - http://www.scopus.com/inward/record.url?scp=77249117286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77249117286&partnerID=8YFLogxK

U2 - 10.1016/j.biomaterials.2009.12.030

DO - 10.1016/j.biomaterials.2009.12.030

M3 - Article

C2 - 20153890

AN - SCOPUS:77249117286

VL - 31

SP - 3465

EP - 3470

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

IS - 13

ER -