Abstract
Based on the proposed mechanism, the electronic effects of various ligands on the stereoselectivity and reaction rate of the rhodium(I)-catalyzed asymmetric Pauson-Khand-type reaction were examined. We demonstrated that both the reaction rate and the enantioselectivity are significantly dependent on the electron density of the ligands; when ligands bearing deshielded phosphine were utilized, the reaction rate was slower, but the products were obtained with improved enantioselectivity.
Original language | English |
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Pages (from-to) | 4053-4059 |
Number of pages | 7 |
Journal | Synthesis |
Issue number | 23 |
DOIs | |
Publication status | Published - 2006 Dec 1 |
Keywords
- Asymmetric catalysts
- Atropisomeric ligands
- BINAP ligands
- Electronic effects
- Pauson-Khand reaction
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry