The eNOS Gene Single Nucleotide Polymorphism Is Associated with Early Recurrence of Atrial Fibrillation after Radiofrequency Catheter Ablation

Jaemin Shim, Hui Nam Pak, Hye Jin Hwang, Jong Youn Kim, Boyoung Joung, Moon Hyoung Lee, Yangsoo Jang

Research output: Contribution to journalArticle

Abstract

Background: Previous reports have demonstrated the association between eNOS gene single nucleotide polymorphism (SNP) and atrial fibrillation (AF). This study evaluated whether eNOS gene variants are associated with AF recurrence after radiofrequency Catheter ablation. Methods: A total of 295 consecutive patients (mean age 56 ±11 years, 78% male) with drug-refractory paroxysmal (68.7%) or persistent (31.3%) AF who underwent Catheter ablation were included. Two SNPs, rs2070744 and rs1799983 were genotyped. Results: Early recurrence (ER) of AF (within 3 months) was observed in 33.7%, whereas late recurrence (LR) of AF (after 3months) occurred in 23.1% of the patients during the median 12 months follow-up. The patients with persistent AF had more ER (40.8% vs. 26.4%, p=0.012). Genotype frequencies of the rs2070744 variant in patients with ER or LR were similar to those without ER or LR. In contrast, carriers of the variant allele (T) of the rs1799983 had an increased risk of ER (OR 2.357, 95% CI 1.194-4.652, p=0.013). Multiple logistic regression analysis showed that the rs1799983 variant (OR 2.512, 95% CI 1.2455.068, p=0.010) and persistent AF (OR 1.938, 95% CI 1.088-3.451, p=0.025) were independent predictors of ER. Conclusions: The variant of rs1799983 in eNOS gene may increase the risk for early recurrence of AF after Catheter ablation via decreased eNOS gene activity.

Original languageEnglish
Number of pages1
JournalJournal of Arrhythmia
Volume27
Issue number4
DOIs
Publication statusPublished - 2011 Jan 1
Externally publishedYes

Fingerprint

Catheter Ablation
Atrial Fibrillation
Single Nucleotide Polymorphism
Recurrence
Genes
Logistic Models
Alleles
Genotype
Regression Analysis

Keywords

  • atrial fibrillation
  • Catheter ablation
  • single nucleotide polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The eNOS Gene Single Nucleotide Polymorphism Is Associated with Early Recurrence of Atrial Fibrillation after Radiofrequency Catheter Ablation. / Shim, Jaemin; Pak, Hui Nam; Hwang, Hye Jin; Kim, Jong Youn; Joung, Boyoung; Lee, Moon Hyoung; Jang, Yangsoo.

In: Journal of Arrhythmia, Vol. 27, No. 4, 01.01.2011.

Research output: Contribution to journalArticle

Shim, Jaemin ; Pak, Hui Nam ; Hwang, Hye Jin ; Kim, Jong Youn ; Joung, Boyoung ; Lee, Moon Hyoung ; Jang, Yangsoo. / The eNOS Gene Single Nucleotide Polymorphism Is Associated with Early Recurrence of Atrial Fibrillation after Radiofrequency Catheter Ablation. In: Journal of Arrhythmia. 2011 ; Vol. 27, No. 4.
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abstract = "Background: Previous reports have demonstrated the association between eNOS gene single nucleotide polymorphism (SNP) and atrial fibrillation (AF). This study evaluated whether eNOS gene variants are associated with AF recurrence after radiofrequency Catheter ablation. Methods: A total of 295 consecutive patients (mean age 56 ±11 years, 78{\%} male) with drug-refractory paroxysmal (68.7{\%}) or persistent (31.3{\%}) AF who underwent Catheter ablation were included. Two SNPs, rs2070744 and rs1799983 were genotyped. Results: Early recurrence (ER) of AF (within 3 months) was observed in 33.7{\%}, whereas late recurrence (LR) of AF (after 3months) occurred in 23.1{\%} of the patients during the median 12 months follow-up. The patients with persistent AF had more ER (40.8{\%} vs. 26.4{\%}, p=0.012). Genotype frequencies of the rs2070744 variant in patients with ER or LR were similar to those without ER or LR. In contrast, carriers of the variant allele (T) of the rs1799983 had an increased risk of ER (OR 2.357, 95{\%} CI 1.194-4.652, p=0.013). Multiple logistic regression analysis showed that the rs1799983 variant (OR 2.512, 95{\%} CI 1.2455.068, p=0.010) and persistent AF (OR 1.938, 95{\%} CI 1.088-3.451, p=0.025) were independent predictors of ER. Conclusions: The variant of rs1799983 in eNOS gene may increase the risk for early recurrence of AF after Catheter ablation via decreased eNOS gene activity.",
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AU - Joung, Boyoung

AU - Lee, Moon Hyoung

AU - Jang, Yangsoo

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AB - Background: Previous reports have demonstrated the association between eNOS gene single nucleotide polymorphism (SNP) and atrial fibrillation (AF). This study evaluated whether eNOS gene variants are associated with AF recurrence after radiofrequency Catheter ablation. Methods: A total of 295 consecutive patients (mean age 56 ±11 years, 78% male) with drug-refractory paroxysmal (68.7%) or persistent (31.3%) AF who underwent Catheter ablation were included. Two SNPs, rs2070744 and rs1799983 were genotyped. Results: Early recurrence (ER) of AF (within 3 months) was observed in 33.7%, whereas late recurrence (LR) of AF (after 3months) occurred in 23.1% of the patients during the median 12 months follow-up. The patients with persistent AF had more ER (40.8% vs. 26.4%, p=0.012). Genotype frequencies of the rs2070744 variant in patients with ER or LR were similar to those without ER or LR. In contrast, carriers of the variant allele (T) of the rs1799983 had an increased risk of ER (OR 2.357, 95% CI 1.194-4.652, p=0.013). Multiple logistic regression analysis showed that the rs1799983 variant (OR 2.512, 95% CI 1.2455.068, p=0.010) and persistent AF (OR 1.938, 95% CI 1.088-3.451, p=0.025) were independent predictors of ER. Conclusions: The variant of rs1799983 in eNOS gene may increase the risk for early recurrence of AF after Catheter ablation via decreased eNOS gene activity.

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