The expression of bcl-2 and bcl-6 protein in normal and malignant transitional epithelium

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The bcl-2 proto-oncogene plays a key role in cell longevity by preventing apoptosis. Bcl-2 is important in developing and maintaining the normal function of lymphoid and epithelial tissues. The bcl-6 protein is a 96 kDa nuclear protein selectively expressed in mature B cells within normal germinal centers as well as in their transformed counterparts in diffuse large B cell lymphoma. Recently, the bcl-6 protein has also been reported to be expressed in normal skin and epidermal neoplasms. In this study, 47 cases of transitional cell carcinomas (TCCs) were immunohistochemically studied for bcl-2 and bcl-6 protein expression. The results showed that bcl-2 was expressed only on basal layer cells, whereas bcl-6 expression was restricted to the superficial layers in the normal transitional epithelium. Von Brunn's nests showed strong immunostaining to bcl-2, but were negative to bcl-6. Among 47 TCCs, 15 (32.6%) and 29 (61.7%) cases were positive for bcl-2 and bcl-6, respectively. Compared with the normal transitional epithelium, the expression of bcl-2 was significantly decreased, whereas bcl-6 expression was significantly increased in TCCs. Additionally, the strong expression of bcl-6 had a positive correlation with the histopathologic grade of TCC. In conclusion, bcl-2 and bcl-6 proteins may play a role in the pathogenesis of TCCs, and bcl-6 expression reflects histopathologic grade.

Original languageEnglish
Pages (from-to)272-275
Number of pages4
JournalUrological Research
Volume31
Issue number4
DOIs
Publication statusPublished - 2003 Aug 1

Fingerprint

Transitional Cell Carcinoma
Epithelium
Proteins
Germinal Center
Proto-Oncogenes
Lymphoma, Large B-Cell, Diffuse
Lymphoid Tissue
Skin Neoplasms
Nuclear Proteins
B-Lymphocytes
Apoptosis

Keywords

  • Bcl-2
  • Bcl-6
  • Immunohistochemistry
  • Transitional cell carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

The expression of bcl-2 and bcl-6 protein in normal and malignant transitional epithelium. / Lin, Zhenhua; Kim, Han Kyeom; Park, Hong Seok; Kim, Young Sik; Cheon, Jun; Kim, Insun.

In: Urological Research, Vol. 31, No. 4, 01.08.2003, p. 272-275.

Research output: Contribution to journalArticle

@article{b8299c2005964d3db8185fb1ee7eccf4,
title = "The expression of bcl-2 and bcl-6 protein in normal and malignant transitional epithelium",
abstract = "The bcl-2 proto-oncogene plays a key role in cell longevity by preventing apoptosis. Bcl-2 is important in developing and maintaining the normal function of lymphoid and epithelial tissues. The bcl-6 protein is a 96 kDa nuclear protein selectively expressed in mature B cells within normal germinal centers as well as in their transformed counterparts in diffuse large B cell lymphoma. Recently, the bcl-6 protein has also been reported to be expressed in normal skin and epidermal neoplasms. In this study, 47 cases of transitional cell carcinomas (TCCs) were immunohistochemically studied for bcl-2 and bcl-6 protein expression. The results showed that bcl-2 was expressed only on basal layer cells, whereas bcl-6 expression was restricted to the superficial layers in the normal transitional epithelium. Von Brunn's nests showed strong immunostaining to bcl-2, but were negative to bcl-6. Among 47 TCCs, 15 (32.6{\%}) and 29 (61.7{\%}) cases were positive for bcl-2 and bcl-6, respectively. Compared with the normal transitional epithelium, the expression of bcl-2 was significantly decreased, whereas bcl-6 expression was significantly increased in TCCs. Additionally, the strong expression of bcl-6 had a positive correlation with the histopathologic grade of TCC. In conclusion, bcl-2 and bcl-6 proteins may play a role in the pathogenesis of TCCs, and bcl-6 expression reflects histopathologic grade.",
keywords = "Bcl-2, Bcl-6, Immunohistochemistry, Transitional cell carcinoma",
author = "Zhenhua Lin and Kim, {Han Kyeom} and Park, {Hong Seok} and Kim, {Young Sik} and Jun Cheon and Insun Kim",
year = "2003",
month = "8",
day = "1",
doi = "10.1007/s00240-003-0324-3",
language = "English",
volume = "31",
pages = "272--275",
journal = "Urolithiasis",
issn = "2194-7228",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - The expression of bcl-2 and bcl-6 protein in normal and malignant transitional epithelium

AU - Lin, Zhenhua

AU - Kim, Han Kyeom

AU - Park, Hong Seok

AU - Kim, Young Sik

AU - Cheon, Jun

AU - Kim, Insun

PY - 2003/8/1

Y1 - 2003/8/1

N2 - The bcl-2 proto-oncogene plays a key role in cell longevity by preventing apoptosis. Bcl-2 is important in developing and maintaining the normal function of lymphoid and epithelial tissues. The bcl-6 protein is a 96 kDa nuclear protein selectively expressed in mature B cells within normal germinal centers as well as in their transformed counterparts in diffuse large B cell lymphoma. Recently, the bcl-6 protein has also been reported to be expressed in normal skin and epidermal neoplasms. In this study, 47 cases of transitional cell carcinomas (TCCs) were immunohistochemically studied for bcl-2 and bcl-6 protein expression. The results showed that bcl-2 was expressed only on basal layer cells, whereas bcl-6 expression was restricted to the superficial layers in the normal transitional epithelium. Von Brunn's nests showed strong immunostaining to bcl-2, but were negative to bcl-6. Among 47 TCCs, 15 (32.6%) and 29 (61.7%) cases were positive for bcl-2 and bcl-6, respectively. Compared with the normal transitional epithelium, the expression of bcl-2 was significantly decreased, whereas bcl-6 expression was significantly increased in TCCs. Additionally, the strong expression of bcl-6 had a positive correlation with the histopathologic grade of TCC. In conclusion, bcl-2 and bcl-6 proteins may play a role in the pathogenesis of TCCs, and bcl-6 expression reflects histopathologic grade.

AB - The bcl-2 proto-oncogene plays a key role in cell longevity by preventing apoptosis. Bcl-2 is important in developing and maintaining the normal function of lymphoid and epithelial tissues. The bcl-6 protein is a 96 kDa nuclear protein selectively expressed in mature B cells within normal germinal centers as well as in their transformed counterparts in diffuse large B cell lymphoma. Recently, the bcl-6 protein has also been reported to be expressed in normal skin and epidermal neoplasms. In this study, 47 cases of transitional cell carcinomas (TCCs) were immunohistochemically studied for bcl-2 and bcl-6 protein expression. The results showed that bcl-2 was expressed only on basal layer cells, whereas bcl-6 expression was restricted to the superficial layers in the normal transitional epithelium. Von Brunn's nests showed strong immunostaining to bcl-2, but were negative to bcl-6. Among 47 TCCs, 15 (32.6%) and 29 (61.7%) cases were positive for bcl-2 and bcl-6, respectively. Compared with the normal transitional epithelium, the expression of bcl-2 was significantly decreased, whereas bcl-6 expression was significantly increased in TCCs. Additionally, the strong expression of bcl-6 had a positive correlation with the histopathologic grade of TCC. In conclusion, bcl-2 and bcl-6 proteins may play a role in the pathogenesis of TCCs, and bcl-6 expression reflects histopathologic grade.

KW - Bcl-2

KW - Bcl-6

KW - Immunohistochemistry

KW - Transitional cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0141457523&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141457523&partnerID=8YFLogxK

U2 - 10.1007/s00240-003-0324-3

DO - 10.1007/s00240-003-0324-3

M3 - Article

C2 - 12879322

AN - SCOPUS:0141457523

VL - 31

SP - 272

EP - 275

JO - Urolithiasis

JF - Urolithiasis

SN - 2194-7228

IS - 4

ER -